U-0126 from Cayman Chemical

Product Specs
ItemU-0126
CompanyCayman Chemical
Price $130.00Supplier Page View Company Product Page
Catalog Number70970
Research AreaCell Biology, Cell Signaling, Endocrinology & Metabolism, Nutrient Sensing
FormatA crystalline solid
Molecular Weight380.5
Purity≥98%
Storage-20
FormulaC18H16N6S2
OriginUSA
TypeInhibitors
Quantity5 mg

Specifications/Features

Ki, IC, EC, or working concentration: MEK1: IC50 = 72 nM
MEK2: IC50 = 58 nM

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Targeting Activated Pathways in Doxorubicin-Resistant TNBC Alters Signaling, Survival and EMT: A Double-Edged SwordInt J Mol SciMarch 19, 2026Irem Dogan Turacli, Sahika Cingir Koker, Kubra Paspal Eroglu, Banu Yalcin10 μM PI3K inhibitor (LY294002, CST, cat. no: 9901P) or 10 μM MEK inhibitor (U0126, Cayman, cat. no: 70970). After 24, 48 and 72 h, a MTT assay was performed according to the manufacturer’s instructions. Color

(2) LCP1 upregulation via EGFR signaling promotes oral cancer progression through the JAK2/STAT3/IL-1β axisCancer Cell IntOctober 3, 2025Chiao-Rou Liu, Chia-Yu Yang, Kai-Ping Chang, Xiu-Ya Chan, Chu-Mi Hung, Kuan-Ming Lai, Hao-Ping Liu, Chih-Ching WuEGFR inhibitor. GSK1059615 (Cat. No. 11569; Cayman Chemical, Ann Arbor, Michigan, USA), U0126 (Cat. No. 70970; Cayman Chemical), and ruxolitinib (Cat. No. 11609; Cayman Chemical) were utilized to inhibit PI3K,

(3) Integrating collecting systems in human kidney organoids through fusion of distal nephron to ureteric budCell stem cellJuly 3, 2025Shi M, Crouse B, Sundaram N, Pode Shakked N, Thorner K, King NM, Dutta P, Ester L, Zhang W, Govindarajah V, et al.450-10 LDN193189,Cayman Chemical,Cat# 19396 Retinoic Acid,Sigma Aldrich,Cat# R2625 U0126,Cayman Chemical,Cat# 70970 XAV939,Cayman Chemical,Cat# 13596 Y-27632,Cayman Chemical,Cat# 10005583 Fetal Bovine Serum (FBS),Thermo

(4) AZI2 mediates TBK1 activation at unresolved selective autophagy cargo receptor complexes with implications for CD8 T-cell infiltration in breast cancerAutophagyMarch 1, 2024Yeo SK, Haas M, Manupati K, Hao M, Yang F, Chen S, Guan JL.(MedChemExpress, HY-15192); Amlexanox, 100 µM (MedChemExpress, HY-B0713); U0126, 10 µM (Cayman Chemical, 70970); IRAK 1–4 Inhibitor I, 10 µM (MedChemExpress, HY-13329); SP600125, 25 µM (MedChemExpress, HY-12041);

(5) TCR ligand potency differentially impacts PD-1 inhibitory effects on diverse signaling pathwaysThe Journal of experimental medicineDecember 4, 2023Chan W, Cao YM, Zhao X, Schrom EC, Jia D, Song J, Sibener LV, Dong S, Fernandes RA, Bradfield CJ, et al.stimulation under chemical inhibitor conditions, Jurkat cells were pretreated with 10 μM of U0126 (70970; Cayman Chemical), 10 μM of JNK Inhibitor VIII (15946; Cayman Chemical), 25 μM of SB 203580 (13067;

(6) Cannabidiol acts as molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediatorsCell Chemical BiologyDecember 1, 2023Lukas K. Peltner, Lars Gluthmann, Friedemann Börner, Simona Pace, Robert K. Hoffstetter, Christian Kretzer, Rosella Bilancia, Federica Pollastro, Andreas Koeberle, Giovanni Appendino, et al.(Δ9-THC),Appendino et al. [37],N/A triton X-100,Sigma,Cat#T8787; CAS: 9036–19-5 U-0126,Cayman Chemical,Cat#70970; CAS: 109511–58-2 zymosan A (Saccharomyces cerevisiae),Sigma,Cat#Z4250; CAS: 58856–93-2 ,, Experimental Models

(7) A stepwise and digital pattern of RSK phosphorylation determines the outcome of thymic selectioniScienceSeptember 15, 2023Funasaki S, Hatano A, Nakatsumi H, Koga D, Sugahara O, Yumimoto K, Baba M, Matsumoto M, Nakayama KI.and recombinant proteins" ,, BI-D1870,Enzo Life Science,Cat#BML-EI407 U0126,Cayman Chemicals,Cat#70970 GSK2334470,Sigma,Cat#SML0217 SL0101,Cayman Chemicals,Cat#11704 MytomycinC,Nakarai,Cat# 20898-21 Hoechst33342,Dojindo,Cat#

(8) CXCL5 suppression recovers neovascularization and accelerates wound healing in diabetes mellitusCardiovascular diabetologyJuly 7, 2023Chen C, Lin LY, Chen JW, Chang TT.an extracellular signal-regulated kinase (ERK) inhibitor (10 μM; U0126; Cayman Chemical Company, No. 70970, Ann Arbor, MI, USA) and a selective CXCR2 antagonist (10 or 100 nM; SB332235; Cayman Chemical Company,

(9) Biliary epithelial cells are facultative liver stem cells during liver regeneration in adult zebrafishJCI InsightJanuary 10, 2023Isaac M. Oderberg, Wolfram Goesslingin the dark. Stock solutions for AG1478 (Selleck Chemicals, S2728), U0126 (Cayman Chemical Company, 70970), LY290002 (Selleck Chemicals, S1105), and Rapamycin (Selleck Chemicals, AY-22989) were made by dissolution

(10) Copper bis(thiosemicarbazone) complexes modulate Pâ€glycoprotein expression and function in human brain microvascular endothelial cellsJournal of NeurochemistryAugust 1, 2022Jae Pyun, Lachlan E. McInnes, Paul S. Donnelly, Celeste Mawal, Ashley I. Bush, Jennifer L. Short, Joseph A. Nicolazzo2020) were purchased from Cell Signalling Technology (Danvers, MA). The MEK1/2 inhibitor U‐0126 (Cat# 70970, 2020) was purchased from Cayman Chemical (Ann Arbor, MI). Odyssey blocking buffer in PBS (Cat# LCR‐927‐40

(11) Phosphorylation of mixed lineage kinase MLK3 by cyclin-dependent kinases CDK1 and CDK2 controls ovarian cancer cell divisionThe Journal of biological chemistryAugust 1, 2022Cedeno-Rosario L, Honda D, Sunderland AM, Lewandowski MD, Taylor WR, Chadee DN.following inhibitors: 1 μg/ml nocodazole (catalog no.: 487928; MilliporeSigma), 100 μM U0126 (catalog no.: 70970; Cayman Chemical), 10 μM SB202190 (catalog no.: S7067; MilliporeSigma), 0.1 μM JNK-IN-8 (catalog no.:

(12) Oncostatin M Induces Lipolysis and Suppresses Insulin Response in 3T3-L1 AdipocytesInternational journal of molecular sciencesApril 23, 2022Bailey JL, Hang H, Boudreau A, Elks CM.Cayman Chemical, Ann Arbor, MI, USA; # 10007448), the MEK inhibitor, U0126 (50mM; Cayman Chemical, #70970), or an anti-OSMR antibody (10 μg/well; Santa Cruz Biotechnology, Dallas, TX, USA; #sc-8493), were used.

(13) Recruitment of DNA to tumor-derived microvesiclesCell reportsMarch 1, 2022Clancy JW, Sheehan CS, Boomgarden AC, D'Souza-Schorey C.1211877-36-9 Chloroquine phosphate,Cayman Chemical,Cat#14194; CAS# 50-63-5 U0126,Cayman Chemical,Cat#70970; CAS# 109511-58-2 Sulforhodamine B,MilliporeSigma,Cat#230162-5G; CAS# 3520-42-1 Trichloroacetic Acid,MilliporeSigma,Cat#T6399-250G;

(14) Salviolone from Salvia miltiorrhiza Roots Impairs Cell Cycle Progression, Colony Formation, and Metalloproteinase-2 Activity in A375 Melanoma Cells: Involvement of P21(Cip1/Waf1) Expression and STAT3 PhosphorylationInternational journal of molecular sciencesJanuary 20, 2022Zanrè V, Campagnari R, Cerulli A, Masullo M, Cardile A, Piacente S, Menegazzi M.USA) plus 1% Antibiotic Antimycotic Solution (Gibco, Thermo Scientific). The MEK1 inhibitor U0126 (CAY-70970) and the PI3K inhibitor LY294002 (CAY-70920) were provided by Cayman Chemical, Ann Arbor, MI, USA. 4.6.

(15) ERK contributes to B cell receptor-induced cell spreading in the A20 mouse B cell linemicroPublication biologyJanuary 1, 2022Peters V, Deretic N, Choi K, Gold MR.#SML0320) (Tocris Bioscience, #3706) (Ohori et al., 2005) and the MEK inhibitor U0126 (Cayman Chemical, #70970) (Favata et al., 1998) were used at final concentrations of 30 µM. siRNA transfection and immunoblotting Using

(16) TLR and IKK Complex-Mediated Innate Immune Signaling Inhibits Stress Granule AssemblyJournal of immunology (Baltimore, Md. : 1950)July 1, 2021Samir P, Place DE, Malireddi RKS, Kanneganti TD.of 1 μg/mL was used to stimulate TLR7/8. SB203580 (Selleckchem, S1076) and U0126 (Cayman Chemicals, 70970) were used at the concentration of 10 μM to inhibit P38 and ERK1/2, respectively. SP600125 (Selleckchem,

(17) Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulationsCancer cellJune 14, 2021Affo S, Nair A, Brundu F, Ravichandra A, Bhattacharjee S, Matsuda M, Chin L, Filliol A, Wen W, Song X, et al.Human Aggrecan aa20-675/His, biotin",R&D,CUSTOM-Protein U-0126 ERK-inhibitor,Cayman Chemical,Cat: #70970 Hyaluronidase from bovine testes Type IV-S,Millipore Sigma,Cat: #H4272 Hyaluronan (High MW),R&D,Cat:

(18) Inhibition of aberrant tissue remodelling by mesenchymal stromal cells singly coated with soft gels presenting defined chemomechanical cuesNature Biomedical EngineeringJune 3, 2021Sing Wan Wan Wong, Chandramohan R. Tamatam, Ik Sung Cho, Peter T. Toth, Raymond Bargi, Patrick Belvitch, James C. Lee, Jalees Rehman, Sekhar P. Reddy, Jae-Won ShinCayman Chemical: SB203580 (13067, 10 μM) to inhibit p38 MAPK, SP600125 (10010466, 20 μM) to inhibit JNK, U0126 (70970, 5 μM) to inhibit ERK1/2. The stock solutions of the inhibitors were dissolved in dimethylsulfoxide

(19) Redundant and Cooperative Roles for Yersinia pestis Yop Effectors in the Inhibition of Human Neutrophil Exocytic Responses Revealed by Gain-of-Function ApproachInfection and immunityFebruary 20, 2020Pulsifer AR, Vashishta A, Reeves SA, Wolfe JK, Palace SG, Proulx MK, Goguen J, Bodduluri SR, Haribabu B, Uriarte SM, et al.temperature (RT) for 30 min with 1 ␮M latrunculin A (catalog [cat.] no. 428021; Sigma), 20 ␮M U0126 (cat. no. 70970; Cayman), 50 nM LY293111 (cat. no. 10009768; Cayman), or 3 ␮M (5Z)-7-oxozeaenol (cat. no. 17459; Cayman).

(20) TAK1 signaling regulates p53 through a mechanism involving ribosomal stressScientific reportsFebruary 13, 2020Zonneville J, Wong V, Limoge M, Nikiforov M, Bakin AV.11140, CAS № 494772-86-0) and 5Z-7-oxozeaenol,Ox1, (Cat# 17459, CAS № 253863-19-3), and U0126 (Cat#70970) were obtained from Cayman Chemical (Ann Arbor, Michigan); 5Z-7-oxozeaenol, Ox2, (Cat#3604) was obtained

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U-0126

U-0126

U-0126 from Cayman Chemical

Description

Specifications/Features

Cayman Chemical

Citations (31)

Reviews

U-0126 from Cayman Chemical

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