Description
A BTK inhibitor (IC50 = 2.5 µM); selective for BTK over JAK1, JAK3, IRK, EGFR, and HCK (IC50s = >278 µM for all), as well as a panel of seven serine/threonine, 10 tyrosine, and one lipid kinase (IC50s = >200-500 µM), but does inhibit PLK3 (Ki = 7.2 µM) and Plx1 (IC50 = 10 µM); increases anti-FAS antibody-induced apoptosis in NALM-6-UM-1 ALL cells; reduces tumor growth in an MMTV/neu transgenic mouse model of breast cancer at 50 mg/kg