Description
An agonist of GPR40/FFA1 (EC50 = 47.8 nM); selective for GPR40/FFA1 over GPR120/FFA4 (EC50 = 3,467 nM), as well as GPR43/FFA2 and GPR41/FFA3 (EC50s = >50 µM); potentiates glucose-stimulated and potassium chloride-mediated insulin secretion in MIN6 cells; activates AMPK-ACC signaling; decreases hepatic lipid accumulation in a mouse model of high-cholesterol diet-induced hepatic steatosis at 100 mg/kg per day for three days