Etoposide from Cayman Chemical

An inhibitor of topoisomerase II (IC50 = 60.3 µM); inhibits proliferation of a variety of adenocarcinoma cells (IC50s = 0.005-12,200 µM) and HUVEC cells (IC50 = 0.249 µM); reduces tumor growth in an Ma human embryonal carcinoma mouse xenograft model at 25 mg/kg, an effect enhanced by cyclosporin A; inhibits nuclear receptor coactivator 3 (IC50 = 2.48 µM)