Description
A potent, cell permeable PI3K inhibitor (IC50 = 11, 350, 18, and 58 nM for p110 subunit isoforms α, β, γ, and δ, respectively); reduces chemotaxis and induces apoptosis in chronic lymphocytic leukemia B cells; blocks proliferation of glioma cells in vitro; blocks insulin-stimulated phosphorylation of Akt in L1 adipocytes and L6 myotubes; prevents activation of the mTORC1 pathway