Methotrexate (hydrate) from Cayman Chemical

Product Specs
ItemMethotrexate (hydrate)
CompanyCayman Chemical
Price $53.00Supplier Page View Company Product Page
Catalog Number13960
Quantity100 mg
Research AreaAutoimmunity, Cancer, Immunology & Inflammation, Immunosuppressants, Rheumatoid Arthritis
FormatA crystalline solid
Molecular Weight454.4
Purity≥98%
Storage-20
FormulaC20H22N8O5 • XH2O
OriginCHN
TypeInhibitors

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Brief pulses of high-level fluid shear stress enhance metastatic potential and rapidly alter the metabolism of cancer cellsCell ReportsFebruary 24, 2026Amanda N. Pope, Devon L. Moose, Guy O. Hudson, Hank R. Weresh, Marion R. Dykstra, Aabha Y. Joshi, Patrick Breheny, Eric B. Taylor, Michael D. Henrywere pre-treated with 10 μM or 0.1% DMSO for 3 h prior to FSS exposure. Methotrexate hydrate (MTX) (13960, Cayman Chemical) was dissolved in dimethylformamide (DMF), and cells were treated with 1 μM MTX or

(2) De novo purine metabolism is a metabolic vulnerability of cancers with low p16 expressionbioRxivJuly 20, 2023Naveen Kumar Tangudu, Raquel Buj, Jiefei Wang, Aidan R. Cole, Apoorva Uboveja, Richard Fang, Amandine Amalric, Maureen A. Lyons, Uma R. Chandran, Katherine M. Aird(Sartorius). Briefly, cells were seeded in 96 well plate and treated with drug, either methotrexate (13960; Cayman Chemical Company) or lometrexol hydrate (18049; Cayman Chemical Company), in the presence of 1

(3) Pathway-specific effects of ADSL deficiency on neurodevelopmenteLifeFebruary 8, 2022Dutto I, Gerhards J, Herrera A, Souckova O, Škopová V, Smak JA, Junza A, Yanes O, Boeckx C, Burkhalter MD, et al.Blue Solution,Sigma,Cat# B8438, "Chemical compound, drug",MTX (methotrexate),Cayman Chemical,Cat# 13960,100 µM in DMSO "Chemical compound, drug",EmbryoMax Nucleosides 100×,Merck,Cat# ES-008-D,1× in media

(4) Differential toxicity to murine small and large intestinal epithelium induced by oncology drugsCommunications biologyJanuary 27, 2022Bieber JM, Sanman LE, Sun X, Hammerlindl H, Bao F, Roth MA, Koleske ML, Huang L, Aweeka F, Wu LF, et al.tissue harvest To test for increased toxicity to the small intestine in vivo, MTX (Cayman Chemicals #13960) or CP (Sigma–Aldrich #C3250000) at 100 mg/kg in PBS were administered to mice by intraperitoneal injection

(5) Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcomaCell reportsJanuary 26, 2021Rathore R, Caldwell KE, Schutt C, Brashears CB, Prudner BC, Ehrhardt WR, Leung CH, Lin H, Daw NC, Beird HC, et al.Scientific,Cat# AAJ6218709 Glycine 1 M solution,Sigma-Aldrich,Cat# 67419 Methotrexate,Cayman Chemical,Cat# 13960 NCT-503 Inactive Control,Sigma-Aldrich,Cat# SML1671 NCT-503,Sigma-Aldrich,Cat# SML1659 PKUMDL-WQ-2101,Sigma-Aldrich,Cat#

(6) The mammalian cholesterol synthesis enzyme squalene monooxygenase is proteasomally truncated to a constitutively active formThe Journal of biological chemistryJanuary 1, 2021Coates HW, Capell-Hattam IM, Brown AJ.(296; Ajax Finechem), methanol (318; Ajax Finechem), l-methionine (M9625; Sigma–Aldrich), methotrexate (13960; Cayman Chemical Company), mevalonolactone (mevalonate; M4667; Sigma–Aldrich), mevastatin (compactin;

(7) Silicon Nanofluidic Membrane for Electrostatic Control of Drugs and Analytes ElutionPharmaceuticsJuly 19, 2020Nicola Di Trani, Antonia Silvestri, Yu Wang, Danilo Demarchi, Xuewu Liu, Alessandro Grattonifunctionalized, 777978-10MG, Sigma Aldrich, St. Louis, MO, USA) or 2.5 mg/mL PBS solution of methotrexate (13960, Cayman Chemical, Ann Arbor, MI, USA). Both molecules possess a negative charge at pH 7.4, with methotrexate presenting

(8) MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung CancerCancer cellJuly 13, 2020Augert A, Mathsyaraja H, Ibrahim AH, Freie B, Geuenich MJ, Cheng PF, Alibeckoff SP, Wu N, Hiatt JB, Basom R, et al.5 % CO2 and 95 % air. METHOD DETAILS Chemicals Methotrexate was purchased from Cayman chemical (13960), resuspended according to the manufacturer’s recommendations and used at concentrations ranging from

(9) Glycolysis-Independent Glucose Metabolism Distinguishes TE from ICM Fate during Mammalian EmbryogenesisDevelopmental cellApril 6, 2020Chi F, Sharpley MS, Nagaraj R, Roy SS, Banerjee U.#11593 Lometrexol (250–500nM),Cayman Chemical,Cat #18049 Methotrexate (200nM),Cayman Chemical,Cat #13960 Mizoribine (1μM),Cayman Chemical,Cat #23128 AVN-944 (50nM),Cayman Chemical,Cat #21284 Leflunomide

(10) SLC19A1 transports immunoreactive cyclic dinucleotidesNatureSeptember 1, 2019Luteijn RD, Zaver SA, Gowen BG, Wyman SK, Garelis NE, Onia L, McWhirter SM, Katibah GE, Corn JE, Woodward JJ, et al.tetrahydrofolic acid (Cayman Chemical Company, cat. #: 16159), methotrexate (Cayman Chemical Company, cat. #: 13960), folic acid (Cayman Chemical Company, cat. #: 20515), sulfasalazine (Sigma-Aldrich, cat. #: S0883),

(11) Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder CancerCellApril 5, 2018Lee SH, Hu W, Matulay JT, Silva MV, Owczarek TB, Kim K, Chua CW, Barlow LJ, Kandoth C, Williams AB, et al.,Cayman Chemical,Cat#15007 5-Fluorouracil,Cayman Chemical,Cat#14416 Ifosfamide,Cayman Chemical,Cat#17562 Methotrexate,Cayman Chemical,Cat#13960 Mitomycin C,Sigma-Aldrich,Cat#M4287 Vinblastine,Selleck Chemicals,Cat#S1248 Paclitaxel,Cayman Chemical,Cat#10461 Docetaxel,Cayman Chemical

(12) Nicotinamide Phosphoribosyltransferase Deficiency Potentiates the Antiproliferative Activity of Methotrexate through Enhanced Depletion of Intracellular ATPThe Journal of pharmacology and experimental therapeuticsApril 1, 2018Singh RK, van Haandel L, Heruth DP, Ye SQ, Leeder JS, Becker ML, Funk RS.(catalog no. N1630; SigmaAldrich) were dissolved in water at 0.1 M concentration. MTX (catalog no. 13960; Cayman Chemical Company) was dissolved in 100% DMSO (catalog no. BP231-100; Thermo Fisher Scientific)

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Methotrexate (hydrate) from Cayman Chemical

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Cayman Chemical

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Methotrexate (hydrate) from Cayman Chemical

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