Pyripyropene A from Cayman Chemical

A potent inhibitor of ACAT2 (IC50 = 70 nM) with high selectivity over the ACAT1 isozyme (IC50 > 80 µM); 10-50 mg/kg per day for 12 weeks lowers plasma and hepatic cholesterol, VLDL, and LDL content in apolipoprotein E-knockout mice