Description
An immunosuppressive mycotoxin with diverse biological activities; inhibits 20S proteasomal chymotrypsin activity (IC50 = 10 µM); induces apoptosis in monocytes and dendritic cells and reduces phagocytosis by neutrophils; presses viral infection by Nipah and Hendra virus in HEK293T cells (IC50s = 149 and 579 nM, respectively); inhibits LTA4H epoxide hydrolase activity and LTB4 synthesis n neutrophils and monocytes under reducing conditions; reduces LTB4 plasma levels and blocks peritoneal neutrophil infiltration in a mouse model of zymosan A-induced peritonitis at 5 mg/kg; inhibits geranylgeranyltransferase I and farnesyltransferase (IC50s = 17 and 80 µM, respectively)