Ionomycin (calcium salt) from Cayman Chemical

Product Specs
ItemIonomycin (calcium salt)
CompanyCayman Chemical
Price $45.00Supplier Page View Company Product Page
Catalog Number11932
Quantity1 mg
Research AreaAdaptive Immunity, Calcium Mobilization, Cell Biology, Cell Signaling, Immunology & Inflammation, Innate Immunity, NETosis
FormatA crystalline solid
Molecular Weight747.1
Purity≥98%
Storage-20
FormulaC41H70O9 • Ca
OriginISR

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Hypoxia Impairs CD8+ T Cell Fitness and Is Associated with a Dysfunctional CD8+ T Cell State in Pancreatic CancerCancers (Basel)May 8, 2026Ashley M. Mello, Marina Pasca di Magliano, Kyoung Eun Leeconditions with PMA (5 ng/mL, #10008014, Cayman Chemical, Ann Arbor, MI, USA), ionomycin (0.5 μg/mL, #11932, Cayman Chemical), and Brefeldin A (10 μg/mL, #11861, Cayman Chemical). For the proliferation assays,

(2) ERM proteins support perinuclear actin rim formationFrontiers in Cell and Developmental BiologyJanuary 21, 2026Yuval Hadad, Andrea Fracchia, Dagmawit Babele, Amit Ben Shushan, Gabi Gerlitztransfected with DNA plasmids, and incubated for another 24 h before further analysis. 1.5 mM Ionomycin (11932, Cayman Chemical Company, Ann Arbor, MI, United States) was added for various periods. Immunostaining Cells

(3) Membrane receptors cluster phosphatidylserine to activate LC3-associated phagocytosisNature Cell BiologySeptember 22, 2025Emilio Boada-Romero, Clifford S. Guy, Gustavo Palacios, Luigi Mari, Suresh Poudel, Zhenrui Li, Piyush Sharma, Douglas R. Greenimmunofluorescence and/or flow cytometry. Reagents Compounds and drugs Ionomycin (Cayman Chemical, 11932), fendiline-HCl (Tocris, 6407), selective PI4KIII inhibitor (GSK-A1; Cayman Chemical, 34502), mTOR inhibitor

(4) Dietary targeting of TRPM8 rewires macrophage immunometabolism reducing colitis severityCell Death DisApril 25, 2025D. Cicia, F. Biscu, F A Iannotti, M. Miraglia, C. Ferrante, N. Iaccarino, S. Cadenas de Miguel, A. Chiavaroli, A. Schiano Moriello, P. De Cicco, et al.to the maximum Ca2+ influx effect on [Ca2+]i observed with the application of 4 μM ionomycin (cat. 11932, Cayman). Measurement of [Ca2+]i in TRPM8 cells was performed at 22 °C with a Fluorescence Peltier System

(5) Versatile roles of annexin A4 in clear cell renal cell carcinoma: Impact on membrane repair, transcriptional signatures, and composition of the tumor microenvironmentiScienceApril 18, 2025Maximilian Wess, Manuel Rogg, Constance Gueib-Picard, Annika Merz, Anna L. Kössinger, Tobias Feilen, Grigor Andreev, Martin Werner, Ian J. Frew, Markus Grabbert, et al.USA) additionally supplemented with CaCl2 to a final concentration of 2 mM and further 2 μM Ionomycin (11932, Cayman Chemical, Ann Arbor, MI, USA) or the according volume of DMSO (A3672, AppliChem, Darmstadt,

(6) TMEM65 regulates and is required for NCLX-dependent mitochondrial calcium effluxNature MetabolismApril 8, 2025Joanne F. Garbincius, Oniel Salik, Henry M. Cohen, Carmen Choya-Foces, Adam S. Mangold, Angelina D. Makhoul, Anna E. Schmidt, Dima Y. Khalil, Joshua J. Doolittle, Anya S. Wilkinson, et al.96-well plates at 500 cells per well. The following day, 0–20 μM thapsigargin or ionomycin (cat. no. 11932, Cayman Chemical) was added to the medium to induce cellular Ca2+ stress. After 24 h, SYTOX Green (cat.

(7) Purinergic Ca2+ Signaling as a Novel Mechanism of Drug Tolerance in BRAF-Mutant MelanomaCancers (Basel)June 30, 2024Philip E. Stauffer, Jordon Brinkley, David A. Jacobson, Vito Quaranta, Darren R. Tysonaliquoted into single-use tubes, and stored at −20 °C. Ionomycin calcium salt (Cayman Chemical, Ref 11932, Ann Arbor, MI, USA) or cyclopiazonic acid (CPA) (Cayman Chemical, Ref 11326) were dissolved in DMSO

(8) Two-pore channel-2 and inositol trisphosphate receptors coordinate Ca2+ signals between lysosomes and the endoplasmic reticulumCell ReportsJanuary 23, 2024Yu Yuan, Vikas Arige, Ryo Saito, Qianru Mu, Gabriela C. Brailoiu, Gustavo J.S. Pereira, Stephen R. Bolsover, Marco Keller, Franz Bracher, Christian Grimm, et al.brain microvascular endothelial cells),Cat# SML3562 TPC2-A1-P,Franz lab17,N/A Ionomycin,Cayman,Cat# 11932 Thapsigargin,ChemCruz,Cat# sc-24017 Tetrandrine,ChemCruz,Cat# sc-201492A Histamine,Sigma,Cat# H7125 ,, Critical

(9) Functional imaging-guided cell selection for evolving genetically encoded fluorescent indicatorsCell Reports MethodsAugust 1, 2023Chang Lin, Lihao Liu, Peng ZouMatrigel® Matrix,Corning,356234 poly-D-lysine,Sigma,P7280-5X5M Laminin Mouse Protein,Gibco,23017015 Opti-MEM® Medium,Gibco,31985062 Ionomycin,Cayman,11932 Protease K,Thermo,EO0491 HEPES,Amresco,0511 EGTA,Sigma,03777-10G 2-APB,Abcam,ab120124 Gabazine,Abcam,ab120042 NBQX,Abcam,ab120045 D-AP5

(10) Early Endosomes Act as Local Exocytosis Hubs to Repair Endothelial Membrane DamageAdvanced science (Weinheim, Baden-Wurttemberg, Germany)May 1, 2023Raj N, Greune L, Kahms M, Mildner K, Franzkoch R, Psathaki OE, Zobel T, Zeuschner D, Klingauf J, Gerke V.IRDye 680CW (LICOR, 926–32220). Lysosomal exocytosis was induced by 2 µm ionomycin (Cayman Chemical, 11932) in media. To study inhibition of lysosomal exocytosis, U18666A (Sigma‐Aldrich, U3633) was used at 2

(11) MCU gain- and loss-of-function models define the duality of mitochondrial calcium uptake in heart failurebioRxivApril 22, 2023Joanne F. Garbincius, Timothy S. Luongo, Jonathan P. Lambert, Adam S. Mangold, Emma K. Murray, Alycia N. Hildebrand, Pooja Jadiya, John W. Elrodhour. The plates were then changed to fresh media supplemented with 10μM ionomycin (Cayman Chemical #11932) or 2μM antimycin A or vehicle control and incubated at 37°C for 1hr. Dihydroethidium (DHE) (ThermoFisher

(12) Mechanisms and significance of tissue-specific MICU regulation of the mitochondrial calcium uniporter complexMolecular cellOctober 6, 2022Tsai CW, Rodriguez MX, Van Keuren AM, Phillips CB, Shushunov HM, Lee JE, Garcia AM, Ambardekar AV, Cleveland JC Jr, Reisz JA, et al.,GE Healthcare,Cat#17043001 Cycloheximide,Sigma,Cat#C7698 Oligomycin,Cayman,Cat#11342 Rotenone,Cayman,Cat#13995 Antimycin A,Sigma,Cat#A8674 Ionomycin,Cayman,Cat#11932 Carbachol,Cayman,Cat#114486 45Ca2+ radioisotope,Perkin-Elmer,Cat#NEZ013001MC 35S-methionine,Perkin-Elmer,Cat#NEG009A001MC Cysteine/methionine

(13) A platform utilizing Drosophila ovulation for nonhormonal contraceptive screeningProceedings of the National Academy of SciencesJuly 14, 2021Kewa Jiang, Jiyang Zhang, Yuping Huang, Yingzheng Wang, Shuo Xiao, M. Kyle Hadden, Teresa K. Woodruff, Jianjun Sunchemicals were also used: DMSO (Sigma; 276855), octopamine (Sigma; O0250), ionomycin (Cayman Chemical; 11932), niclosamide (Selleckchem; S3030), mianserin hydrochloride (Selleckchem; S1382), phenoxybenzamine hydrochloride

(14) Vascular occlusion by neutrophil extracellular traps in COVID-19EBioMedicineAugust 1, 2020Leppkes M, Knopf J, Naschberger E, Lindemann A, Singh J, Herrmann I, Stürzl M, Staats L, Mahajan A, Schauer C, et al.Molecular Probes™ H2DCFDA (ThermoFisher, Scientific D399), Ionomycin (calcium salt) (Cayman Chemical, 11932), Klebsiella pneumoniae lipopolysaccharide (LPS) (Sigma-Aldrich, L4268), Phorbol 12-myristate 13-acetate

(15) Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal functioneLifeMarch 16, 2020Gerndt S, Chen CC, Chao YK, Yuan Y, Burgstaller S, Scotto Rosato A, Krogsaeter E, Urban N, Jacob K, Nguyen ONP, et al.Biosciences P-3508 Chemical compound, drug Ionomycin Sigma Aldrich and Cayman Chemical I-0634 and 11932 Chemical compound, drug Tetrandrine Sigma Aldrich and Santa Cruz Biotechnology T2695 and sc201492A Chemical compound,

(16) Inducible Pluripotent Stem Cell–Derived Cardiomyocytes Reveal Aberrant Extracellular Regulated Kinase 5 and Mitogen-Activated Protein Kinase Kinase 1/2 Signaling Concomitantly Promote Hypertrophic Cardiomyopathy in RAF1 -Associated Noonan SyndromeCirculationJuly 16, 2019Fabrice Jaffré, Clint L. Miller, Anne Schänzer, Todd Evans, Amy E. Roberts, Andreas Hahn, Maria I. Kontaridis12-myristate 13-acetate (PMA) was purchased from Sigma-Aldrich (#P8139) and ionomycin from Cayman Chemical (#11932). CHIR99021 was obtained from Stem Cell Technologies (#72052). Cell culture. Cell cultures were maintained

(17) Patient-Derived Phenotypic High-Throughput Assay to Identify Small Molecules Restoring Lysosomal Function in Tay-Sachs DiseaseSLAS discovery : advancing life sciences R & DMarch 1, 2019Colussi DJ, Jacobson MA.Methods Chemicals Gly-Phe-β-napthylamide (GPN) (cat. 14634), 2-aminoethyl diphenylborinate (2-APB) (cat. 64970), and ionomycin (cat. 11932) were from Cayman Chemical Co. (Ann Arbor, MI); pyrimethamine (cat. P-7771) was purchased from Sigma

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Ionomycin (calcium salt) from Cayman Chemical

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Cayman Chemical

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Ionomycin (calcium salt) from Cayman Chemical

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