Actinomycin D from Cayman Chemical

Product Specs
ItemActinomycin D
CompanyCayman Chemical
Price $76.00Supplier Page View Company Product Page
Catalog Number11421
Quantity5 mg
Research AreaCancer, Cell Death, DNA Damage and Repair
FormatA crystalline solid
Molecular Weight1255.4
Purity≥95%
Storage-20
FormulaC62H86N12O16
OriginUSA
TypeInhibitors

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Developmental reprogramming underlies chemotherapy resistance in favorable-histology Wilms tumorCell ReportsMarch 24, 2026Andrew M. Fleming, Carolyn M. Jablonowski, Hongjian Jin, Siwei Zhang, Surbhi Sona, Ha Won Lee, Karissa M. Dieseldorff Jones, Changde Cheng, Beisi Xu, Christopher L. Morton, et al.assays),Hospira,N/A Doxorubicin (in vivo assays),Pfizer,N/A Actinomycin-D (in vitro assays),Cayman,Cat#11421 Vincristine (in vitro assays),MedChemExpress,HY-N0488 Doxorubicin (in vitro assays),Cayman,Cat#15007 Verapamil

(2) BRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypesMolecular CellMarch 5, 2026Brandon Chen, Drew C. Stark, Pankaj V. Jadhav, Theophilus M. Lynn-Nguyen, Benjamin S. Halligan, Nicholas J. Rossiter, Nicole Sindoni, Myungsun Shin, Joao A. Paulo, Matthew Chang, et al.,Cayman Chemicals,Cat#11609 dBET6,Cayman Chemicals,Cat#35385 JQ1,Cayman Chemicals,Cat#11187 Actinomycin D,Cayman Chemicals,Cat#11421 AS-2863619,Cayman Chemicals,Cat#30976 NVP2,Cayman Chemicals,Cat#34725 Piericidin A,Cayman Chemicals,Cat#15379 TTFA,Cayman Chemicals

(3) Using MUC2 mucin producing tumorigenic human goblet-like cells to uncover functional properties of the mucus barrierGut MicrobesDecember 31, 2025Hayley Gorman, France Moreau, Elise Beaupré, Nitin Nitin, Wesley F. Zandberg, Kirk Bergstrom, Paul M. K. Gordon, Antoine Dufour, Kris Chadeeusing the 2−ΔΔCT method. For experiments determining the half-life of mRNA, 5 μg of Actinomycin D (11421; Cayman Chemicals) was used for 0, 0.5, 1, 2, 4, 6, 12, and 24 h prior to mRNA extraction and RT-PCR analysis

(4) eEF2K regulates pain through translational control of BDNFMolecular CellFebruary 20, 2025Patrick R. Smith, Guadalupe Garcia, Angela R. Meyer, Alexey G. Ryazanov, Tao Ma, Sarah Loerch, Zachary T. CampbellChemical,CAS No. 121762374-9; Cat. No. 13370 Actinomycin D (ActD),Cayman Chemical,CAS No. 50-76-0; Cat. No. 11421 (R)-MG132,Cayman Chemical,CAS No. 121187736-9; Cat No. 13697 GCN2iB,MedChemExpress,CAS No. 218347012-2;

(5) XIST and MUC1-C form an auto-regulatory pathway in driving cancer progressionCell Death & DiseaseMay 13, 2024Keyi Wang, Atrayee Bhattacharya, Naoki Haratake, Tatsuaki Daimon, Ayako Nakashoji, Hiroki Ozawa, Bo Peng, Wei Li, Donald Kufefollowed by analysis with qRT-PCR. RNA Stability Assay Cells were incubated with 5 μg/ml actinomycin D (11421, Cayman, Ann Arbor, MI, USA) for 0, 3, and 6 h. Total RNA was analyzed by qRT-PCR. N6-methyladenosine-RNA immunoprecipitation

(6) Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibitioneLifeApril 29, 2024Gregory Caleb Howard, Jing Wang, Kristie L Rose, Camden Jones, Purvi Patel, Tina Tsui, Andrea C Florian, Logan Vlach, Shelly L Lorey, Brian C Grieb, et al.drug",2’-Azido-2’-deoxycytidine,Biosynth,Cat# NA05412, "Chemical compound, drug",Actinomycin D,Cayman Chemical Company,Cat# 11421-10mg, "Chemical compound, drug",MB 680R DBCO,Vector Laboratories,Cat# CCT-1462, "Chemical compound,

(7) Ribosome subunit attrition and activation of the p53–MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibitionElifeApril 29, 2024Gregory Caleb Howard, Jing Wang, Kristie L Rose, Camden Jones, Purvi Patel, Tina Tsui, Andrea C Florian, Logan Vlach, Shelly L Lorey, Brian C Grieb, et al.drug",2’-Azido-2’-deoxycytidine,Biosynth,Cat# NA05412, "Chemical compound, drug",Actinomycin D,Cayman Chemical Company,Cat# 11421-10mg, "Chemical compound, drug",MB 680R DBCO,Vector Laboratories,Cat# CCT-1462, "Chemical compound,

(8) Repositioning VU-0365114 as a novel microtubule-destabilizing agent for treating cancer and overcoming drug resistanceMolecular oncologyFebruary 1, 2024Hsieh YY, Du JL, Yang PM.(https://discover.nci.nih.gov/cellminercdb/) [17]. 2.2 Chemicals, reagents, and antibodies Actinomycin D (#11421) and cycloheximide (#14126) were purchased from Cayman Chemical (Ann Arbor, MI, USA). Verapamil (#ab120140)

(9) Forgotten memory storage and retrieval in DrosophilaNature communicationsNovember 7, 2023Wang CM, Wu CY, Lin CE, Hsu MC, Lin JC, Huang CC, Lien TY, Lin HK, Chang TW, Chiang HC.Aesar,Cat#B21618 Cycloheximide,Cayman,Cat#14126 Puromycin,Cayman,Cat#13884 Actinomycin D,Cayman,Cat#11421 Experimental models: Organisms/strains,Experimental models: Organisms/strains,Experimental models:

(10) FXR1 regulates vascular smooth muscle cell cytoskeleton, VSMC contractility, and blood pressure by multiple mechanismsCell reportsApril 25, 2023St Paul A, Corbett C, Peluzzo A, Kelemen S, Okune R, Haines DS, Preston K, Eguchi S, Autieri MV.#13258 Rat Tail Type I Collagen Solution,Advanced BiomatiX,Cat #5153 Actinomycin D,Cayman Chemicals,Cat #11421 ,, Critical commercial assays,Critical commercial assays,Critical commercial assays ,, RT2 ProfilerTM

(11) Biosynthesis of prostaglandin 15dPGJ2 -glutathione and -cysteine conjugates in macrophages and mast cells via MGST3: Biosynthesis of 15dPGJ2-conjugatesJournal of Lipid ResearchDecember 1, 2022Julia Steinmetz-Späh, Jianyang Liu, Rajkumar Singh, Maria Ekoff, Sanjaykumar Boddul, Xiao Tang, Filip Bergqvist, Helena Idborg, Pascal Heitel, Elin Rönnberg, et al.translation inhibition, RAW264.7 cells were pretreated for 4 h with 5 μg/ml actinomycin D (Cayman Chemical, 11421) or 100 μg/ml cycloheximide (Cayman chemical, 14126) prior addition of 2 μM 15dPGJ2 for various time

(12) Adenovirus prevents dsRNA formation by promoting efficient splicing of viral RNANucleic acids researchFebruary 22, 2022Price AM, Steinbock RT, Di C, Hayer KE, Li Y, Herrmann C, Parenti NA, Whelan JN, Weiss SR, Weitzman MD.concentration of 3 μM added 12 hpi. RNA polymerase inhibitor actinomycin D was purchased from Cayman Chemical (11421), resuspended in DMSO, and used at a final concentration of 5 μM added 24 hpi. 5,6-Dichloro-1-β-d-ribofuranosyl-1H-benzimidazole

(13) Aberrant cyclin C nuclear release induces mitochondrial fragmentation and dysfunction in MED13L syndrome fibroblastsiScienceFebruary 18, 2022Chang KT, Jezek J, Campbell AN, Stieg DC, Kiss ZA, Kemper K, Jiang P, Lee HO, Kruger WD, van Hasselt PM, et al.,Cayman Chemical,15218 Oligomycin,Sigma,49455 Rotenone,Sigma,R8875 Antimycin A,Sigma,R8875 MitoTempo,Sigma,SML0737 Actinomycin D,Cayman Chemical,11421 Tetramethylrhodamine (TMRM),Invitrogen,I34361 ,, Critical commercial assays,Critical commercial assays,Critical

(14) Cell Culture Characterization of Prooxidative Chain-Transfer Agents as Novel Cytostatic DrugsMoleculesNovember 8, 2021Victoria Heymans, Sascha Kunath, Parvana Hajieva, Bernd MoosmannArbor, MI, USA (#15007; purity ≥98%); actinomycin D (Act; CAS 50-76-0) was from Cayman Chemicals (#11421; purity ≥95%); 5-fluorouracil (FU; CAS 51-21-8) was from Sigma-Aldrich (#F6627; purity ≥99%); hydroxyurea

(15) Shift in MSL1 alternative polyadenylation in response to DNA damage protects cancer cells from chemotherapeutic agent-induced apoptosisCell reportsOctober 12, 2021Kunisky AK, Anyaeche VI, Herron RS, Park CY, Hwang HW.2000,ThermoFisher,Cat#11668019 Doxorubicin,Sigma,Cat#D1515 camptothecin,Sigma,Cat#C9911 Taxol,Sigma,Cat#T7402 Cisplatin,Sigma,Cat#P4394 KU-55933,Sigma,Cat#SML1109 VE-821,Sigma,Cat#SML1415 DRB,Sigma,Cat#D1916 Flavopiridol,Sigma,Cat#F3055 Doxycycline,Sigma,Cat#D9891 NU-7441,Selleckchem,Cat#S2638 KU60019,Selleckchem,Cat#S1570 AZD7648,Selleckchem,Cat#S8843 Actinomycin D,Cayman Chemical,Cat#11421 Thymidine,Cayman Chemical,Cat#20519 Nocodazole,Cayman Chemical,Cat#13857 Temozolomide,Cayman Chemical,Cat#14163 10%

(16) The Hydroxyquinoline Analogue YUM70 Inhibits GRP78 to Induce ER Stress-Mediated Apoptosis in Pancreatic CancerCancer researchApril 1, 2021Samanta S, Yang S, Debnath B, Xue D, Kuang Y, Ramkumar K, Lee AS, Ljungman M, Neamati N.V-8477), MG132 (Cayman, 10012628), Trypsin (Promega, V5280), VER (Tocris, 3803/10), Actinomycin D (Cayman, 11421), Cycloheximide (Sigma, C6255), CellTracker ™ Green CMFDA dye (Thermo Fisher Scientific, C2925), Tunicamycin

(17) Saikosaponin D exhibits anti-leukemic activity by targeting FTO/m(6)A signalingTheranosticsJanuary 1, 2021Sun K, Du Y, Hou Y, Zhao M, Li J, Du Y, Zhang L, Chen C, Yang H, Yan F, et al.assays The transfected and drug-treated cells were treated with 5 µg/mL actinomycin-D (Cayman Chemical #11421) for the indicated time points. Total RNA was purified using TRIzol® RNA isolation reagent (Invitrogen

(18) Functional Precision Medicine Identifies New Therapeutic Candidates for MedulloblastomaCancer ResearchDecember 1, 2020Jessica M. Rusert et al.mice in pilot experiments, actinomycin D, bortezomib, gambogic acid, idarubicin (all from Cayman, CAT# 11421, 10008822, 14761, 14176 respectively), and oleandrin (MedChemExpress, CAT# HY-13719) were dissolved

(19) Functional precision medicine identifies new therapeutic candidates for medulloblastomaCancer ResOctober 12, 2020Jessica M. Rusert, Edwin F. Juarez, Sebastian Brabetz, James Jensen, Alexandra Garancher, Lianne Q. Chau, Silvia K. Tacheva-Grigorova, Sameerah Wahab, Yoko T. Udaka, Darren Finlay, et al.mice in pilot experiments, actinomycin D, bortezomib, gambogic acid, idarubicin (all from Cayman, CAT# 11421, 10008822, 14761, 14176 respectively), and oleandrin (MedChemExpress, CAT# HY-13719) were dissolved

(20) Adenovirus-mediated ubiquitination alters protein-RNA binding and aids viral RNA processingNature microbiologyOctober 1, 2020Herrmann C, Dybas JM, Liddle JC, Price AM, Hayer KE, Lauman R, Purman CE, Charman M, Kim ET, Garcia BA, et al.infected with either Ad5 WT or ΔE1B were treated with 1 μg/ml Actinomycin D (Cayman Chemical, Cat#: 11421) at 24 hpi. RNA harvested using RLT buffer (from Qiagen RNA isolation kit) at 0, 1, 2, 4, 6, and 8 hours

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Actinomycin D from Cayman Chemical

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Cayman Chemical

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Actinomycin D from Cayman Chemical

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