Description
An inhibitor of autotaxin (IC50 = 2.8 nM in an enzyme assay); reverses leptin-induced MMP-13 expression in human OA chondrocytes at 10 µM; reduces LPA production by >95% following carrageenan-induced inflammation in rats at 30 mg/kg; inhibits autotaxin activity in human whole blood (IC50 = 101 nM)