SAG from Cayman Chemical

Product Specs
ItemSAG
CompanyCayman Chemical
Price $129.00Supplier Page View Company Product Page
Catalog Number11914
Quantity10 mg
Research AreaCell Biology, Cell Signaling, Differentiation, Hedgehog Signaling, Neuroprotection, Neuroscience, Stem Cell Research
FormatA crystalline solid
Molecular Weight490.1
Purity≥98%
Storage-20
FormulaC28H28ClN3OS
OriginCHN

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) ATP13A2 Loss of Function-Driven Polyamine Dysregulation Induces SAM Depletion and Epigenetic Astrocyte ToxicitybioRxivApril 6, 2026Elena Coccia, Gustavo Morrone Parfitt, Sundas Ijaz, Aisha Sati, Julia Gesner, Andrea Perez Arevalo, Jennifer Strong, Anna Bright, Soha Sohail, Thea Meimoun, et al.supplemented with Purmorphamine (2 μM; STEMCELL Technologies, #72202) and SAG (1 μM; Cayman Chemical, #11914) until day 3. On d4-7, midbrain patterning was achieved by adding 3μM of CHIR99021 (Tocris, #99021)

(2) DCPS modulates TDP-43-linked neurodegeneration through P-body-mediated RNA decayNeuronMarch 9, 2026Yingzhi Ye, Zhe Zhang, Yu Xiao, Chengzhang Zhu, Noelle Wright, Julie Asbury, Yongxin Huang, Weiren Wang, Laura Gomez-Isaza, Juan C. Troncoso, et al.#72234 CHIR99021,Cayman Chemical,Cat #13122 Retina acid,Sigma-Aldrich,Cat #R2625 SAG,Cayman Chemical,Cat #11914 DAPT,Sigma-Aldrich,Cat #D5942 db-cAMP,EMD-Millipore,Cat #28745 Compound E,EMD-Millipore,Cat #565790 FDU,MedChem

(3) Blocking RAN translation without altering repeat RNAs rescues C9ORF72 -related ALS and FTD phenotypesScienceFebruary 5, 2026Xin Jiang, Laure Schaeffer, Divya Patni, Tommaso Russo, Chao-Zong Lee, Corey Aguilar, Christine Marques, Karen Jansen-West, Marian Hruska-Plochan, Ananya Ray-Soni, et al.CHIR99021 (Sigma-Aldrich, SML1046), All-trans RA (Sigma-Aldrich, R2625), and SAG (Cayman Chemicals, 11914) with Rock Inhibitor (Y-27632, Sigma-Aldrich, 688000). Stage 2 medium was changed on day 7, day 9, and

(4) Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domainsMolecular CellJanuary 8, 2026Lin Guo, Jacob R. Mann, Jocelyn C. Mauna, Katie E. Copley, Hejia Wang, Jack D. Rubien, Cristian A. Bergmann, Jenny L. Carey, Jessica Merjane, Marilyn Ngo, et al.,StemCell Technologies,72234 LDN-193189,Sigma-Aldrich,SML0559 Retinoic Acid (RA),Sigma-Aldrich,R2625 Smoothened-Agonist (SAG),Cayman Chemical,11914 SU5402,Cayman Chemical,13182-5 DAPT,Cayman Chemical,13197 TrypLE,Gibco,12604013 DNAseI,Invitrogen,18-047-019 BDNF,PeproTech,450-02 GDNF,PeproTech,450-10 CNTF,PeproTech,450-13 Ascorbic

(5) TDP-43 directly inhibits mRNA accumulation in neurites through modulation of mRNA stabilityThe EMBO JournalDecember 15, 2025Charlie Moffatt, Ankita Arora, Katherine F Vaeth, Bryan B Guzman, Gurprit Bhardwaj, Audrey Hoelscher, Levi B Gifford, Holger A Russ, Daniel Dominguez, J Matthew Taliaferro,STEMCELL Technologies,#72102 SB431542,STEMCELL Technologies,#72234 CHIR99021,STEMCELL Technologies,#72054 SAG,Cayman,#11914 TTNPB,Tocris,#0761 TrypLE,Thermo Fisher,#12604021 Cryostor 10,Biolife Solutions,#210502 poly-l-lysine,Sigma-Aldrich,#P4707 Matrigel,Corning,#354277 deep

(6) The mGluR5 agonist CHPG enhances human oligodendrocyte differentiationActa Neuropathol CommunOctober 3, 2025Yangyang Huang, Celine Geywitz, Anjalika Bandaru, Ian A Glass, Birth Defects Research Laboratory, Lucas Schirmer, Hiroko Nobuta, Cheryl F Dreyfusbasic FGF (Peprotech 100-18B, final concentration 10 ng/ml). The concentration of SAG (Cayman Chemical 11914) was 0.5 mM, T3 was 40 ng/ml, NT3 was 1 ng/ml. Penicillin–Streptomycin was omitted from N2 medium, HGF

(7) APOE4 promotes cerebrovascular fibrosis and amyloid deposition via a pericyte-to-myofibroblast transitionbioRxivSeptember 16, 2025Braxton R. Schuldt, Dominic Haworth-Staines, Andrea Perez-Arevalo, Diede W.M. Broekaart, Leon Wang, Georgia Gallagher, Grace Rabinowitz, Alison M. Goate, Towfique Raj, Ana C. Pereira, et al.15140122 Streptomycin,, Puromycin,Gibco,Cat# A1113803 Retinoic Acid,MIllipore,Cat# R2625 SAG,Cayman,Cat# 11914 SB431542,Stemgent,Cat# 04-0010 StemFlex,Gibco,Cat# A3349401 TGFB1,Peprotech,Cat# 100-21 TrypLE Select,Gibco,Cat#

(8) G-quadruplexes as a source of vulnerability in BRCA2 - deficient granule cell progenitors and medulloblastomaProceedings of the National Academy of SciencesSeptember 2, 2025Danielle L. Keahi, Mathijs A. Sanders, Matthew R. Paul, Andrew L. H. Webster, Yin Fang, Tom F. Wiley, Samer Shalaby, Thomas S. Carroll, Settara C. Chandrasekharappa, Carolina Sandoval-Garcia, et al.Plated GCPs were cultured on coated glass coverslips and treated with 100 nM SAG (Cayman Chemical, #11914) for 3 h or 12 h as well as pyridostatin (MedChemExpress #HY-15176A) at 2.5 μM, 5 μM, or 10 μM. EdU

(9) 3D‐Printed Scaffolds Promote Enhanced Spinal Organoid Formation for Use in Spinal Cord InjuryAdvanced Healthcare MaterialsSeptember 1, 2025Guebum Han, Nicolas S. Lavoie, Nandadevi Patil, Olivia G. Korenfeld, Hyunjun Kim, Manuel Esguerra, Daeha Joung, Michael C. McAlpine, Ann M. ParrMedium supplemented with BGJ398 (100 nM, S2183, Selleck Chemicals, TX), smoothened agonist (500nM, 11914, Cayman Chemical, MI), and Wnt‐C59 (250nM, 5148, Tocris Bioscience, MN). On day 4, the cells were placed

(10) RAB23 loss-of-function mutation causes context-dependent ciliopathy in Carpenter syndromePLOS GeneticsAugust 18, 2025Wan Ying Leong, Wai Lam Tung, Andrew O. M. Wilkie, Catherine Hong Huan Hor(Addgene #110494; Li et al., 2016) [49]. On day 4 post-infection, 0.2 μM SAG (Cayman Chemical, catalog #11914–1) was added to the culture and incubated for 24 hours. Green fluorescence reporter signals were measured

(11) Prediction of the hypothalamus-pituitary organoid formation using machine learningCell Reports MethodsAugust 18, 2025Ryusaku Matsumoto, Hidetaka Suga, Yutaka Takahashi, Takashi Aoi, Takuya YamamotoTesque,16973–64 Y-27632,FUJIFILM,034–24024 Recombinant human BMP4,R&D systems,314-BP SAG,Cayman Chemical,11914 4% paraformaldehyde,Nacalai Tesque,09154–85 O.C.T. compound,Sakura Finetek,09154–85 RNeasy Mini kit,Qiagen,74104 TB

(12) Genetically encoded and modular subcellular organelle probes reveal dysfunction in lysosomes and mitochondria driven by PRKN knockoutiScienceJuly 18, 2025Camille Goldman, Tatyana Kareva, Lily Sarrafha, Braxton R. Schuldt, Abhishek Sahasrabudhe, Tim Ahfeldt, Joel W. Blanchardaddition of 3 μM CHIR99021 (Tocris 4423), 2 μM purmorphamine (Stemcell 72204), and 1 μM SAG (Cayman 11914) starting 4 days after neural induction. After patterning, media was changed to DMEM/F12 with GlutaMAX,

(13) An organ-chip model of sporadic ALS using iPSC-derived spinal cord motor neurons and an integrated blood-brain-like barrierCell Stem CellJuly 3, 2025Deepti Lall, Michael J. Workman, Samuel Sances, Briana N. Ondatje, Shaughn Bell, George Lawless, Amanda Woodbury, Dylan West, Amanda Meyer, Andrea Matlock, et al.,Cayman Chemicals,Cat#13122 All-Trans Retinoic Acid (ATRA),Stemgent,Cat#04-0021 Smoothened agonist (SAG),Cayman Chemicals,Cat#11914 Y-27632 (ROCKi),StemCell Technologies,Cat#72308 Dibutyryl-cAMP (dbcAMP),Millipore-Sigma,Cat#28745 Recombinant Human FGF-basic

(14) Brain-wide neuronal circuit connectome of human glioblastomaNatureMay 1, 2025Yusha Sun, Xin Wang, Daniel Y. Zhang, Zhijian Zhang, Janardhan P. Bhattarai, Yingqi Wang, Kristen H. Park, Weifan Dong, Yun-Fen Hung, Qian Yang, et al.generate GABAergic neurons, EBs were further cultured in F2 medium supplemented with 100 nM SAG (Cayman, 11914) and patterned to medial ganglionic eminence (MGE) fate for 7 days. After switching to F3 medium for

(15) Drug and siRNA screens identify ROCK2 as a therapeutic target for ciliopathiesCommun Med (Lond)April 19, 2025Claire E. L. Smith, Andrew J. Streets, Alice V. R. Lake, Subaashini Natarajan, Sunayna K. Best, Katarzyna Szymanska, Magdalena Karwatka, Thomas Stevenson, Rachel Trowbridge, Gary Grant, et al.receptor, from the ciliary membrane23. Hydroxyfasudil, the positive control Smoothened agonist (SAG; Cayman 11914) or vehicle controls were added after 24 h to final concentrations of 10 µM and 250 nM, respectively.

(16) PTPσ-mediated PI3P regulation modulates neurodegeneration in C9ORF72-ALS/FTDNeuronApril 16, 2025Zhe Zhang, Xiujuan Fu, Noelle Wright, Weiren Wang, Yingzhi Ye, Julie Asbury, Yini Li, Chengzhang Zhu, Rong Wu, Shaopeng Wang, et al.trans retina acid (RA) at 0.1μM (Sigma-Aldrich, Cat. No. R2625) and 1μM SAG (Cayman Chemical, Cat. No. 11914). 6 days following passage (differentiation day 12), cells were seeded on Matrigel coated plates and

(17) Cholesterol-mediated Lysosomal Dysfunction in APOE4 Astrocytes Promotes α-Synuclein Pathology in Human Brain TissuebioRxivFebruary 14, 2025Louise A. Mesentier-Louro, Camille Goldman, Alain Ndayisaba, Alice Buonfiglioli, Rikki B. Rooklin, Braxton R. Schuldt, Abigail Uchitelev, Vikram Khurana, Joel W. BlanchardAF-100-14B Penicillin-Streptomycin,Gibco,Cat# 15140122 Puromycin,Gibco,Cat# A1113803 Retinoic Acid,MIllipore,Cat# R2625 SAG,Cayman,Cat# 11914 SB431542,Stemgent,Cat# 04-0010 StemFlex,Gibco,Cat# A3349401 T0901317,MedChem Express,Cat# HY-10626 TrypLE

(18) Non-cell-autonomous regulation of mTORC2 by Hedgehog signaling maintains lipid homeostasisCell ReportsJanuary 28, 2025Kylie R. VanDerMolen, Martin A. Newman, Peter C. Breen, Yunjing Gao, Laura A. Huff, Robert H. Dowenrecombinant insulin,Thermo Fisher Scientific,Cat# 12585014 Smoothened agonist,Cayman Chemicals,Cat# 11914 Smoothened agonist,Santa Cruz Biotechnology,Cat# sc-212905 siGLO Green Transfection Indicator,Horizon

(19) Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathyCell ReportsJanuary 28, 2025Mari Aikio, Hana M. Odeh, Heike J. Wobst, Bo Lim Lee, Úna Chan, Jocelyn C. Mauna, Korrie L. Mack, Bradley Class, Thomas A. Ollerhead, Alice F. Ford, et al.72234 LDN193189,Sigma-Aldrich,Cat # SML0559 Retinoic Acid,Sigma-Aldrich,Cat #R2625 Smoothened-Agonist (SAG),Cayman Chemical,Cat# 11914 DAPT,Cayman Chemical,Cat# 13197 BDNF,PeproTech,Cat # 450-02 GDNF,PeproTech,Cat # 450-10 CNTF,PeproTech,Cat

(20) G-quadruplexes are a source of vulnerability in BRCA2 deficient granule cell progenitors and medulloblastomabioRxivJuly 25, 2024Danielle L. Keahi, Mathijs A. Sanders, Matthew R. Paul, Andrew L. H. Webster, Yin Fang, Tom F. Wiley, Samer Shalaby, Thomas S. Carroll, Settara C. Chandrasekharappa, Carolina Sandoval-Garcia, et al.concentration of 50,000 cells per coverslip in 500ul media. GCPs were treated with 100nM SAG (Cayman Chemical, #11914) for 3h or 12h as well as pyridostatin (MedChemExpress #HY-15176A) at 2.5uM, 5uM, or 10uM. EdU (ThermoFisher

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SAG from Cayman Chemical

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