Torin 1 from Cayman Chemical

Product Specs
ItemTorin 1
CompanyCayman Chemical
Price $161.00Supplier Page View Company Product Page
Catalog Number10997
Quantity10 mg
Research AreaCell Biology, Cell Signaling, PI3K/Akt/mTOR Signaling
FormatA crystalline solid
Molecular Weight607.6
Purity≥95%
Storage-20
FormulaC35H28F3N5O2
OriginCHN
TypeInhibitors

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Environmental Amino Acid Sensing Regulates the Rate of ASC Translation and NLRP3 Inflammasome AssemblybioRxivJanuary 23, 2026Mikel D. Haggadone, Brian P. Goldspiel, Aoife O’Farrell, Nora T. Kiledjian, Montana Knight, Talia R. Smith, Elena Anderson, Víctor R. Vázquez Marrero, Mark A. Boyer, Peining Jimmy Xu, et al.concentrations specified in each figure legend. The following inhibitors were used: Torin 1 (Cayman Chemical #10997), rapamycin (MedChemExpress #HY-10219), GCN2iB (MedChemExpress #HY-112654), cycloheximide (Sigma-Aldrich

(2) Glucose availability tunes latent CD8+ T cell expansion potential through a mitogen-independent, mTOR-dependent regulatory switchbioRxivJanuary 21, 2026Tran Ngoc Van Le, Krittin Trihemasava, Lucien Turner, Kelly Rome, Aaron Wu, Will Bailispharmacological reagents, the following doses were used unless otherwise noted: Torin1 (50nM, Cayman Chemical, #10997) and Rapamycin (50nM, Sigma, #R0395). Flow cytometry All flow cytometry was performed on a CytoFLEX

(3) The adenovirus E4orf1 protein initiates a feedback loop involving insulin and growth factor receptors, AKT, and NF-κB, leading to abnormal DNA content in infected cellsPLoS PathogOctober 27, 2025Madison Moore, Jiang Kong, Ahlam Akmel, Michael A. Thomasinhibitors The pharmacological inhibitors used in this study were Torin1 (Cayman Chemical Company Cat #: 10997), LY294002 (Selleckchem Cat #: S1105), Akt inhibitor IV (Millipore Cat #: 124011), SC75741 (Selleckchem

(4) Zika virus impairs autophagic flux in trabecular meshwork, and inhibition of autophagy restricts ocular viral transmission and associated pathologyMicrobiology SpectrumOctober 7, 2025Faraz Ahmad, Prince Kumar, Pallav Singh, Trupti Joshi, Pawan Kumar Singhchloroquine (14194), hydroxychloroquine (17911), bafilomycin A1 (11038), rapamycin (13346), and torin 1 (10997) were purchased from Cayman Chemicals (Ann Arbor, MI). Cells and culture conditions Primary human

(5) Sphingolipid synthesis maintains nuclear membrane integrity and genome stability during cell divisionJ Cell BiolAugust 4, 2025Sunyoung Hwang, William Russo, Jaylah Cormier, Jillian Johnson, Sara Martin, Marica Rosaria Ippolito, Sara Cordone, Rui Li, Lihua Julie Zhu, Stefano Santaguida, et al.µM thymidine (#T9250; Sigma-Aldrich), or 10 μM RO3306 (#SML0569; Sigma-Aldrich). Torin 1 (Cayman) #10997, TOFA (Cayman) #10005263, cerulenin (Cayman) #10005647, C75 (Cayman) #9000783, and lovastatin (Cayman)

(6) Autophagy regulates cellular senescence by mediating the degradation of CDKN1A/p21 and CDKN2A/p16 through SQSTM1/p62-mediated selective autophagy in myxomatous mitral valve degenerationAutophagyJuly 1, 2025Tang Q, Tang K, Markby GR, Parys M, Phadwal K, MacRae VE, Corcoran BM.SA00001–1). Phalloidin-iFluor 488 Reagent (ab176753) was purchased from Abcam. Rapamycin (13346), torin-1 (10997), MG132 (10012628) and bafilomycin A1 (11038) were obtained from Cayman Chemical. Dimethylsulfoxide

(7) A TBK1-independent primordial function of STING in lysosomal biogenesisMolecular CellOctober 17, 2024Bo Lv, William A. Dion, Haoxiang Yang, Jinrui Xun, Do-Hyung Kim, Bokai Zhu, Jay Xiaojun TanNO: 117570-53-3 G150,Cayman Chemical,Cat#28318; CAS NO: 2369751-30-2 Torin 1,Cayman Chemical,Cat#10997; CAS NO: 1222998-36-8 Golgicide A,Cayman Chemical,Cat#18430; CAS NO: 1005036-73-6 ML-SA1,Cayman Chemical,Cat#29958;

(8) Inhibiting the P2Y12 Receptor in Megakaryocytes and Platelets Suppresses Interferon-Associated ResponsesJACC: Basic to Translational ScienceSeptember 1, 2024Marcin A. Sowa, Haoyu Sun, Tricia T. Wang, Vitor W. Virginio, Florencia Schlamp, Hanane El Bannoudi, MacIntosh Cornwell, Hannah Bash, Peter M. Izmirly, H. Michael Belmont, et al.24-well plates at a concentration of 2 × 105 cells/mL and next day treated with 2.5 μmol/L Torin-1 (#10997, Cayman), or 0.1% DMSO (control solution) for 24 hours. After 24 hours of treatment, cells were lysed

(9) Sigma-1 receptor recruits LC3 mRNA to ER-associated omegasomes to promote localized LC3 translation enabling functional autophagyCell ReportsAugust 10, 2024Jeffrey Knupp, Yu-Jie Chen, Emily Wang, Peter Arvan, Billy Tsaigel,Millipore Sigma,Cat#A2220 Anti-HA magnetic beads,Thermo Fisher,Cat#88836 Torin-1,Cayman Chemical,Cat#10997 Bafilomycin A1,Cayman Cheical,Cat#11038 Micrococcal nuclease,New England Biolabs,Cat#M0247S 3xFLAG

(10) HSDL2 links nutritional cues to bile acid and cholesterol homeostasisScience AdvancesMay 31, 2024Nolwenn Samson, Cristina R. Bosoi, Christian Roy, Laurie Turcotte, Laura Tribouillard, Mathilde Mouchiroud, Line Berthiaume, Jocelyn Trottier, Heitor C. G. Silva, Thomas Guerbette, et al.were used in cell culture experiments: rapamycin (LC Laboratories, #R5000), Torin1 (Cayman Chemical, #10997), puromycin (Sigma-Aldrich, #P8833), Blasticidin S-HCl (Sigma-Aldrich, #15205), clofibrate (Cayman Chemical,

(11) Modulations of the mTORC2–GATA3 axis by ‍an ‍isorhamnetin activated endosomal–lysosomal system of the J774.1 macrophage-like cell lineJournal of Clinical Biochemistry and NutritionMarch 20, 2024Maiko Sakai, Kohta Ohnishi, Masashi Masuda, Erika Harumoto, Teppei Fukuda, Aika Ohnishi, Shunsuke Ishii, Hirokazu Ohminami, Hisami Yamanaka-Okumura, Kazuto Ohashi, et al.Inc. (Dallas, TX). The Rab7 (ab137029) antibody was obtained from Abcam Inc. (Cambridge, UK). Torin1 (10997) was purchased from Cayman Chemical Co. (Ann Arbor, MI). Isorhamnetin (1120S) and tamarixetin (1140S)

(12) Activation of Lysosomal Function Ameliorates Amyloid-β-Induced Tight Junction Disruption in the Retinal Pigment EpitheliumMolecules and CellsNovember 30, 2023Dong Hyun Jo, Su Hyun Lee, Minsol Jeon, Chang Sik Cho, Da-Eun Kim, Hyunkyung Kim, Jeong Hun KimAβ1-42 peptide (AG968) was obtained from Millipore (USA). Chloroquine (CQ) (C6628; Sigma, USA), Torin (10997; Cayman Chemical, USA), PP242 (S2218; Selleck Chemicals, USA), and a protease inhibitor cocktail (11697498001;

(13) A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathwayeLifeSeptember 4, 2023R Samuel Herron, Alexander K Kunisky, Jessica R Madden, Vivian I Anyaeche, May Z Maung, Hun-Way HwangSuperMix,QuantaBio,Cat#95054–500, "Chemical compound, drug",DMSO,Sigma,Cat#D2650, "Chemical compound, drug",Torin-1,Cayman Chemical,Cat#10997, "Chemical compound, drug",DharmaFECT1,Horizon Discovery,Cat#T-2001-02, "Chemical compound, drug",DharmaFECT2,Horizon

(14) mTORC1 inhibition impairs activation of the unfolded protein response and induces cell death during ER stress in cardiomyocytesAmerican Journal of Physiology-Heart and Circulatory PhysiologyAugust 1, 2023Christoph Hofmann, Zoe Löwenthal, Marjan Aghajani, Randal J. Kaufman, Hugo A. Katus, Norbert Frey, Christopher C. Glembotski, Mirko Völkers, Shirin DoroudgarSigma-Aldrich), 100 nM rapamycin (Cat. No. sc-3504B, Santa Cruz Biotechnology), 100 nM Torin1 (Cat. No. Cay-10997, Cayman Chemical), or 10 µM compound 147. Compound 147 was a kind gift from Luke Wiseman. Respective

(15) Ferroptosis inhibition by lysosome-dependent catabolism of extracellular proteinCell chemical biologyNovember 17, 2022Armenta DA, Laqtom NN, Alchemy G, Dong W, Morrow D, Poltorack CD, Nathanson DA, Abu-Remalieh M, Dixon SJ.albumin (BSA, Cat# 700–100P) was from Gemini Bio-Products or Sigma Aldrich (Cat# A3294). Torin 1 (Cat# 10997) was from Cayman Chemical. Rapamycin (Cat# BP2963–1), bortezomib (Cat# NC0587961), camptothecin (Cat#

(16) mTOR Contributes to the Proteome Diversity through Transcriptome-Wide Alternative SplicingInternational journal of molecular sciencesOctober 17, 2022Cheng S, Fahmi NA, Park M, Sun J, Thao K, Yeh HS, Zhang W, Yong J.lines were cultured at 37 °C with 5% CO2. 4.2. Chemicals Cycloheximide (No. 14126) and Torin 1 (No. 10997) were purchased from Cayman Chemical, Ann Arbor, MI, USA (No. 14126) and reconstituted in DMSO. 4.3.

(17) mTORC2 suppresses cell death induced by hypo-osmotic stress by promoting sphingomyelin transportThe Journal of cell biologyApril 4, 2022Ono Y, Matsuzawa K, Ikenouchi J.(bSMase) from Staphylococcus aureus was purchased from Sigma-Aldrich. Myriocin (CAY 63150), Torin 1 (CAY 10997), and Ku-0063794 (CAY 13597) were obtained from Cayman Chemical. HPA-12 (H1553) was obtained from Tokyo

(18) ZNF768 links oncogenic RAS to cellular senescenceNature communicationsAugust 17, 2021Villot R, Poirier A, Bakan I, Boulay K, Fernández E, Devillers R, Gama-Braga L, Tribouillard L, Gagné A, Duchesne É, et al.experiments: Tamoxifen (Sigma, #T5648), PD098059 (Cayman Chemical, #10006726), Torin1 (Cayman Chemical, #10997), Cycloheximide (Sigma, #C7698), Puromycin (Sigma, #P8833), Blasticidin S-HCl (ThermoFischer Scientific,

(19) A chemical genomics-aggrephagy integrated method studying functional analysis of autophagy inducersAutophagyAugust 1, 2021Kataura T, Tashiro E, Nishikawa S, Shibahara K, Muraoka Y, Miura M, Sakai S, Katoh N, Totsuka M, Onodera M, et al.Chemical Corporation. Brefeldin A (203729) was purchased from Calbiochem. MG132 (10012628) and torin1 (10997) were purchased from Cayman Chemical. Rapamycin (R-5000) was purchased from LC Laboratories. Clemastine

(20) Promotion of Anti-Tuberculosis Macrophage Activity by L-Arginine in the Absence of Nitric OxideFrontiers in ImmunologyMay 14, 2021Melanie C. McKell, Rebecca R. Crowther, Stephanie M. Schmidt, Michelle C. Robillard, Rachel Cantrell, Maria A. Lehn, Edith M. Janssen, Joseph E. QuallsCayman Chemical), 2-deoxyglucose (2-DG, D8375, Sigma-Aldrich), rapamycin (A8167, ApexBio), torin 1 (10997, Cayman Chemical) and/or dimethyl sulfoxide (DMSO, D8418, Sigma-Aldrich, used as vehicle control for

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Torin 1 from Cayman Chemical

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Cayman Chemical

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Torin 1 from Cayman Chemical

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