Description
A fungal metabolite with diverse biological activities; inhibits METAP2 (IC50 = 10 nM); inhibits tube formation in a rat blood vessel organ culture assay at 10 ng/ml; inhibits E. cuniculi replication in isolated rabbit kidney cells and canine embryo cells at 5 µg/ml; decreases tumor growth and the number of metastases in a mouse model of diethylnitrosamine-induced hepatocellular carcinoma at 30 mg/kg; reduces subcutaneous and gonadal fat mass in a mouse model of high-fat diet-induced obesity