Atorvastatin (calcium salt hydrate) from Cayman Chemical

Product Specs
ItemAtorvastatin (calcium salt hydrate)
CompanyCayman Chemical
Price $71.00Supplier Page View Company Product Page
Catalog Number10493
Quantity25 mg
FormatA crystalline solid
Molecular Weight577.7
Purity≥98%
TypeInhibitors
Research AreaCardiovascular System, Cholesterol Metabolism, Lipid Biochemistry, Lipids & Lipoproteins, Sterol Lipids
Storage-20
FormulaC33H34FN2O5 • 1/2Ca [XH2O]
OriginCHN

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Targeting HIF-2α in colorectal cancer reveals a cholesterol biosynthesis–dependent ferroptotic vulnerabilityCancer & MetabolismFebruary 12, 2026Prarthana J. Dalal, Rashi Singhal, Boyan Hu, Drew Stark, Nicholas J. Rossiter, Chesta Jain, Peter Sajjakulnukit, Costas A. Lyssiotis, Yatrik M. Shahpitavastatin, simvastatin, Z-Vad, necrostatin-1, and FG4592 were purchased from Cayman Chemical (Cat# 10493, 15414, 10010344, 15294). Sytox Green was purchased from Thermo Fisher Scientific (Cat# S7020). Animals

(2) Reprogramming of cholesterol sensing in epithelial cells supports pancreatic inflammationMolecular MetabolismJanuary 1, 2026Giulia Milan, Olga A. Mareninova, Marco Fantuz, Martina Spacci, Carlotta Paoli, Jerik A. Pineda, Roberta Noè, Beatrice Calciolari, Roberto Zoncu, Anna S. Gukovskaya, et al.NPC1 inhibitor); Torin-1 (Sigma-Aldrich; #475991 – mTORC1 inhibitor), Atorvastatin (Cayman Chemicals; #10493 – HMGCR inhibitor), Zaragozic acid (Sigma-Aldrich; #Z2626 – SQS inhibitor), recombinant murine EGF (PeproTech;

(3) Lipophilic Statins Deplete GPX4 to Promote Ferroptosis and Sensitize Cancer Cells to Immune Checkpoint BlockadeMolecular cancer therapeuticsDecember 22, 2025Talty R, Brooks VT, McGeary MK, Milette S, Zheng S, Flem-Karlsen K, Daniels A, Deshmukh M, Park K, Caraccio W, et al.atorvastatin – as indicated or experimentally determined IC50 (YR1.7: 200 μM, MC38: 100 μM; Cayman Chemical, #10493), fluvastatin – as indicated or IC50 (YR1.7: 250 μM, MC38: 50 μM; Cayman Chemical, #10010334), lovastatin

(4) SREBP activation contributes to fatty acid accumulations in necroptosis†RSC Chemical BiologyApril 5, 2023Daniel Lu, Laura R. Parisi, Omer Gokcumen, G. Ekin Atilla-GokcumenEnzo (Cat # ALX-260-020), TNF-α was obtained from R&D Systems (Cat #210-TA/CF). Atorvastatin (Cat # 10493). BIBB 515 (Cat # 10010517), Ro48-8071 (Cat # 10006415), U18666A (Cat # 10009085), Betulin (Cat # 11041),

(5) Oleic acid-induced metastasis of KRAS/p53-mutant colorectal cancer relies on concurrent KRAS activation and IL-8 expression bypassing EGFR activationTheranosticsJanuary 1, 2023Shen CJ, Chan RH, Lin BW, Li NC, Huang YH, Chang WC, Chen BK.BioVision). Vitamin E (25985), hygromycin B (hydrate: 14291), reparixin (21492), and atorvastatin (10493) were purchased from Cayman (Cayman). Atorvastatin (Lipitor; VITARIS) was used for feeding mice. Cytokine

(6) Sterol dysregulation in Smith-Lemli-Opitz syndrome causes astrocyte immune reactivity through microglia crosstalkDisease models & mechanismsDecember 1, 2022Freel BA, Kelvington BA, Sengupta S, Mukherjee M, Francis KR.Cayman Chemical, 10009085) and atorvastatin (2.5 µM; HMG-CoA reductase inhibitor; Cayman Chemical, 10493). All comparisons for statistical analyses were made relative to vehicle-treated controls (dimethyl

(7) MicroRNA-dependent inhibition of WEE1 controls cancer stem-like characteristics and malignant behavior in ovarian cancerMolecular therapy. Nucleic acidsSeptember 13, 2022Cho JG, Kim SW, Lee A, Jeong HN, Yun E, Choi J, Jeong SJ, Chang W, Oh S, Yoo KH, et al.body weight; Cat. C2538; Sigma-Aldrich, St. Louis, MO, USA) weekly or atorvastatin (10 mg/kg body weight; Cat. 10493; Cayman, Ann Arbor, MI, USA) by i.p. injection daily. To avoid toxicity in the case of carboplatin and

(8) Cholesterol Regulates the Tumor Adaptive Resistance to MAPK Pathway InhibitionJournal of proteome researchDecember 3, 2021Wang XD, Kim C, Zhang Y, Rindhe S, Cobb MH, Yu Y.AMG-510, MRTX-1257 were purchased from MedChemExpress (MCE). Atorvastatin (calcium salt) (Item No. 10493) was from Cayman chemical. Insulin, MβCD and FITC-CTXb were from Sigma. SILAC cell culture A375 and

(9) Sterols lower energetic barriers of membrane bending and fission necessary for efficient clathrin-mediated endocytosisCell ReportsNovember 16, 2021Ruthellen H. Anderson, Kem A. Sochacki, Harika Vuppula, Brandon L. Scott, Elizabeth M. Bailey, Maycie M. Schultz, Jason G. Kerkvliet, Justin W. Taraska, Adam D. Hoppe, Kevin R. Francis,Cayman Chemical,Item No. 14611 U-18666A,Cayman Chemical,Item No. 10009085 Atorvastatin,Cayman Chemical,Item No. 10493 Simvastatin,Cayman Chemical,Item No. 10010344 methyl-β-cyclodextrin (MβCD)-cholesterol complex,Sigma,C4951 Alfa

(10) Dipyridamole Inhibits Lipogenic Gene Expression by Retaining SCAP-SREBP in the Endoplasmic ReticulumCell chemical biologyFebruary 18, 2021Esquejo RM, Roqueta-Rivera M, Shao W, Phelan PE, Seneviratne U, Am Ende CW, Hershberger PM, Machamer CE, Espenshade PJ, Osborne TF.Laemmli Sample Buffer,Bio-Rad,Cat#1610747 Brefeldin A,Cayman Chemical,Cat#11861-5 "Atorvastatin, calcium salt",Cayman Chemical,Cat#10493 Cycloheximide,Cayman Chemical,Cat#14126 Forskolin,Cayman Chemical,Cat#11018 Methanol,Fisher Scientific,Cat#A456-4 Chloroform,Fisher

(11) Serotonin transporter regulation by cholesterol-independent lipid signalingBiochemical pharmacologyJanuary 1, 2021Deveau CM, Rodriguez E, Schroering A, Yamamoto BK.Methyl-β-cyclodextrin (mβCD) (C4555), and DAPI (D9542) were purchased from Sigma Aldrich (St. Louis, MO). Atorvastatin (10493), Fluvastatin (10010337), Simvastatin (10010344), Farnesyl pyrophosphate (FPP) (63250), Geranylgeranyl

(12) Rosuvastatin Enhances VSV-G Lentiviral Transduction of NK Cells via Upregulation of the Low-Density Lipoprotein ReceptorMolecular Therapy - Methods & Clinical DevelopmentJune 12, 2020Ying Gong, Roel G.J. Klein Wolterink, Ian Janssen, Arjan J. Groot, Gerard M.J. Bos, Wilfred T.V. Germeraadround-bottom 96-well plates (3799, Corning Life Sciences B.V., Amsterdam, the Netherlands). Atorvastatin (10493, Cayman Chemical), fluvastatin (10010337, Cayman Chemical), pravastatin (10010342, Cayman Chemical),

(13) Expansion, in vivo–ex vivo cycling, and genetic manipulation of primary human hepatocytesProceedings of the National Academy of SciencesJanuary 21, 2020Eleftherios Michailidis et al.diclofenac (catalog no. D6899; Sigma), clozapine (catalog no. C6305; Sigma), and atorvastatin (catalog no. 10493; Cayman chemical) were dissolved in DMSO and added to mpPHH cultures at the final concentrations indicated. Plasmodium Infection

(14) Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human MicroliversCell metabolismMarch 5, 2019Mancio-Silva L, Fleming HE, Miller AB, Milstein S, Liebow A, Haslett P, Sepp-Lorenzino L, Bhatia SN.A7085 "L-Buthionine-(S,R)-Sulfoximine",Cayman chemical,Cat# 14484 Atorvastatin,Cayman chemical,Cat# 10493 ,, Critical Commercial Assays,Critical Commercial Assays,Critical Commercial Assays ,, P450-Glo CYP3A4 Assay

(15) Acetyl-CoA Metabolism Supports Multistep Pancreatic TumorigenesisCancer discoveryMarch 1, 2019Carrer A, Trefely S, Zhao S, Campbell SL, Norgard RJ, Schultz KC, Sidoli S, Parris JLD, Affronti HC, Sivanand S, et al.(Orlistat: Cayman Chemical #CAS96829-58-2; 30 μM), HMGCR inhibitor (Atorvastatin, Cayman Chemicals #10493; 20 μM), JQ1 (AdooQ Biosciences #A12729 for in vivo experiments; in vitro quantities provided by James

(16) Heme oxygenase-1-Dependent anti-inflammatory effects of atorvastatin in zymosan-injected subcutaneous air pouch in micePloS oneJanuary 1, 2019El-Achkar GA, Mrad MF, Mouawad CA, Badran B, Jaffa AA, Motterlini R, Hamade E, Habib A.14 Anti-inflammatory effects of atorvastatin in vivo Frontier Scientific (Logan, UT, USA). Atorvastatin (10493) and prostaglandin (PG) E2 EIA measurement reagents were from Cayman Chemicals Company (Ann Arbor, MI,

(17) Systems Pharmacology Dissection of Cholesterol Regulation Reveals Determinants of Large Pharmacodynamic Variability between Cell LinesCell SystemsDecember 27, 2017Peter Blattmann, David Henriques, Michael Zimmermann, Fabian Frommelt, Uwe Sauer, Julio Saez-Rodriguez, Ruedi AebersoldRecombinant Proteins" ,, 25-Hydroxycholesterol,Cayman Chemical,Cat#11097 Atorvastatin,Cayman Chemical,Cat#10493 GW3965,Sigma,Cat#C6295 Trypsin,Promega,Cat#V5113 LysC,WAKO,Cat#121-05063 Lipofectamine RNAiMAX,ThermoFisher,Cat#13778030 iRT

(18) Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicityJournal of Clinical InvestigationJune 30, 2017Deqiang Zhang et al.P21005) were purchased from Sigma-Aldrich. Atorvastatin was obtained from Cayman Chemical (catalog 10493). The high-fructose diet was purchased from Research Diets, and the ingredients are included in the

(19) Development of an in vitro human liver system for interrogating nonalcoholic steatohepatitisJCI insightDecember 8, 2016Feaver RE, Cole BK, Lawson MJ, Hoang SA, Marukian S, Blackman BR, Figler RA, Sanyal AJ, Wamhoff BR, Dash A.control (Sigma-Aldrich, D2650), 0.5 μM OCA (AdipoGen, AG-CR1-3560-M025), or 300 nM atorvastatin (Cayman, 10493) in the lipotoxic milieu with hemodynamics for 10 days. RNA preparation and RNA deep sequencing. Hepatocyte

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Atorvastatin (calcium salt hydrate) from Cayman Chemical

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Cayman Chemical

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Atorvastatin (calcium salt hydrate) from Cayman Chemical

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