Description
A trichothecene mycotoxin; decreases toll-like receptor expression and LPS-induced production of IL-1β, TNF-α, and NO in, and is cytotoxic to (IC50 = 19.47), primary PAMs; induces production of ROS, lipid peroxidation, and GSH depletion in mouse brain and is lethal to mice (LD50s = 1.54-5.94 mg/kg); has been found in Fusarium-infected wheat, barley, and rice crops both in fields and in storage