Description
A specialized pro-resolving mediator; reduces TNF-α-induced increases in ROS in primary human vascular smooth muscle and endothelial cells at 100 nM; decreases disease severity, neutrophil infiltration, and intestinal crypt damage in a mouse model of DSS-induced colitis at 0.3 and 1 µg/animal; inhibits increases in inflammatory exudate PMN infiltration in a mouse model of zymosan A-induced peritonitis at 0.1, 1, and 10 ng/animal; has been found in the synovial fluid of rheumatoid arthritis patients