Description
An RXR agonist (EC50s = 28, 25, and 20 nM for RXRα, RXRβ, and RXRγ, respectively, in reporter assays); selective for RXRs over RARs (RARs; EC50s = >10 µM for RXRα, RXRβ, and RXRγ); induces apoptosis in MJ, HuT 78, and HH CTCL cells at 10 µM; inhibits lung metastasis and angiogenesis in A549 and MDA-MB-231 mouse xenograft models at 100 mg/kg per day; reduces viral load in the culture supernatant of Vero E6 cells infected with SARS-CoV-2 (EC90 = 9.4 µM) and inhibits SARS-CoV-2 replication in a plaque reduction assay (EC50 = 2.01 µM)