Tunicamycin Mixture from Cayman Chemical

Product Specs
ItemTunicamycin Mixture
CompanyCayman Chemical
Price $43.00Supplier Page View Company Product Page
Catalog Number11445
Quantity1 mg
Research AreaBacterial Diseases, Cancer, Cell Biology, Cell Health & Viability, Cell Signaling, Endomembrane System & Vesicular Trafficking, ER Protein Folding, Growth Factor Receptor Signaling, Growth Factor Receptors, Immunology & Inflammation, Infectious Disease, Toxicology & Xenobiotic Metabolism
FormatA crystalline solid
Molecular Weight845
Purity≥95% (mixture of congeners)
Storage-20
FormulaC39H64N4O16 (for Tunicamycin VII)
OriginUSA
TypeInhibitors

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Unique metabolic regulation of micromeres contributes to gastrulation in the sea urchin embryoNat CommunAugust 11, 2025Shakson Isaac, Douglas Dubosky, Ashley Waldron, Natsuko Emura, Aidan Furze, Kavya Rao, Masaru Mori, Ashok Ragavendran, Hideki Makinoshima, Mamiko Yajima5.31050 D-(+)-Glucose,Millipore-Sigma,# G5400 Palmitic Acid,Cayman Chemical,# 10006627 Tunicamycin,Cayman Chemical,#11445 C59,Cayman Chemical,16644 H2O2,Fisher Science,# H323-500 DTT,Millipore-Sigma,# 10197777001 DMSO,Millipore-Sigma,#

(2) Glycosylation of ceramide synthase 6 is required for its activityJournal of lipid researchJanuary 1, 2025Straus AJ, Mavodza G, Senkal CE.nM), thapsigargin (Cayman Chemicals, cat#67526-95-8) at 50 nM, or tunicamycin (Cayman Chemicals, cat#11445) at 0.5 μg/ml (768 nM). Cells were treated for 24 h for cell growth assays or 16 h for all other experiments. Western blotting

(3) The Serine Protease DPP9 and the Redox Sensor KEAP1 Form a Mutually Inhibitory ComplexJournal of Biological ChemistryNovember 29, 2024Lydia P. Tsamouri, Jeffrey C. Hsiao, Daniel A. BachovchinGeldanamycin (GA; Santa Cruz, sc-200617), Brefeldin A (BFA; Biologend, 420601), Tunicamysin (Cayman, 11445), Torin 1 (ThermoFisher Scientific, 4247) Rotenone (ApexBio, B5462), Antimycin A (Sigma Aldrich, A8674),

(4) eIF2B localization and its regulation during the integrated stress response is cell-type specificiScienceSeptember 20, 2024Filipe M. Hanson, Madalena I. Ribeiro de Oliveira, Alison K. Cross, K. Elizabeth Allen, Susan G. Campbell(Tg),Sigma-Aldrich,Cat# T9033 Sodium arsenite (SA),Sigma-Aldrich,Cat# S7400 Tunicamycin (Tm),Cayman Chemical,Cat# 11445 GSK2606414 (PERK inhibitor),Tocris,Cat# 5107 ISRIB,Sigma-Aldrich,Cat# SML0843 Puromycin dihydrochloride,Gibco,Cat#

(5) Perinuclear damage from nuclear envelope deterioration elicits stress responses that contribute to LMNA cardiomyopathyScience AdvancesMay 10, 2024Kunal Sikder, Elizabeth Phillips, Zhijiu Zhong, Nadan Wang, Jasmine Saunders, David Mothy, Andrew Kossenkov, Timothy Schneider, Zuzana Nichtova, Gyorgy Csordas, et al.catalog no. 10522), BFA (Cayman Chemical, catalog no. 11861), tunicamycin (Cayman Chemical, catalog no. 11445), monensin (Cayman Chemical, catalog no. 16488), golgicide A (Cayman Chemical, catalog no. 18430), nigericin

(6) Scd1 and monounsaturated lipids are required for autophagy and survival of adipocytesMolecular metabolismMay 1, 2024Mori H, Peterson SK, Simmermon RC, Overmyer KA, Nishii A, Paulsson E, Li Z, Jen A, Uranga RM, Maung JN, et al.,Cayman Chemical,25689 Recombinant Murine TNF-α,PeproTech,315-01A Thapsigargin,Cayman Chemical,10522 Tunicamycin,Cayman Chemical,11445 Z-VAD(OMe)-FMK,Cayman Chemical,14463 Fatty acid,Fatty acid,Fatty acid Oleic acid,Sigma-Aldrich, Palmitoleic

(7) IRE1 signaling increases PERK expression during chronic ER stressCell Death & DiseaseApril 18, 2024Gideon Ong, Rosemund Ragetli, Katarzyna Mnich, Bradley W. Doble, Wafa Kammouni, Susan E. LogueTechnology, #3700, 1:5000), XBP1s (BioLegend 143F, 1:1000), XBP1s (BioLegend, 9D11A43, 1:1000). Tunicamycin (11445), Thapsigargin (10522), Brefeldin A (11861) were acquired from Cayman Chemicals. MKC8866 was purchased

(8) Establishment of a novel ER-stress induced myopia model in miceEye and vision (London, England)November 1, 2023Kang L, Ikeda SI, Yang Y, Jeong H, Chen J, Zhang Y, Negishi K, Tsubota K, Kurihara T.a.m.) at 23 ± 3 °C. According to the manufacturer’s instructions, Tm (Cayman Chemical, Catalogue #:11445) was dissolved in dimethyl sulfoxide (DMSO) at a concentration of 100 mg/mL, stored at − 20 °C, and

(9) MAGED2 Depletion Promotes Stress-Induced Autophagy by Impairing the cAMP/PKA PathwayInternational journal of molecular sciencesAugust 30, 2023Nasrah S, Radi A, Daberkow JK, Hummler H, Weber S, Seaayfan E, Kömhoff M.Cobalt(II) chloride hexahydrate,"Sigma Aldrich (Schnelldorf, Germany)",C8661 Tunicamycin,"Cayman Chemical (Ann Arbor, MI, USA)",11445 Camptothecin,"Cayman Chemical (Ann Arbor, MI, USA)",11694 2-deoxy-D-glucose,"TCI (Eschborn, Germany)",D0051 Brefeldin

(10) "Nuclear translocation of an aminoacyl-tRNA synthetase may mediate a chronic ""integrated stress response"""Cell reportsJune 27, 2023Jones JA, Wei N, Cui H, Shi Y, Fu G, Rauniyar N, Shapiro R, Morodomi Y, Berenst N, Dumitru CD, et al.NC0418592 Hydrogen peroxide,Millipore Sigma,Catalog#: H1009 Tunicamycin,Cayman Chemical,Catalog#: 11445 Trizol,Life Technologies,Catalog #: 15596026 SYBR Select Master Mix,Applied Biosystems,Catalog #:

(11) Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gutImmunityMay 9, 2023Duan J, Matute JD, Unger LW, Hanley T, Schnell A, Lin X, Krupka N, Griebel P, Lambden C, Sit B, et al.SML0949 GSK2606414,Cayman Chemical,Cat# 17376 PF-429242,Cayman Chemical,Cat# 15140 Tunicamycin,Cayman Chemical,Cat# 11445 Thapsigargin,Cayman Chemical,Cat# 10522 Ampicillin trihydrate,Goldbio,Cat# A-303 Gentamicin sulfate,Goldbio,Cat#

(12) CRISPR/dCas9-KRAB-Mediated Suppression of S100b Restores p53-Mediated Apoptosis in Melanoma CellsCellsFebruary 24, 2023Samrat Roy Choudhury, Billie Heflin, Erin Taylor, Brian Koss, Nathan L. Avaritt, Alan J. Tacketttwo chemotherapeutic agents, cisplatin (13119, Cayman Chemicals, Ann Arbor, MI, USA) and tunicamycin (11445, Cayman Chemicals, Ann Arbor, MI, USA). Drugs were serially diluted from the stock solution (2 mM) and

(13) The PTP1B selective inhibitor MSI-1436 mitigates Tunicamycin-induced ER stress in human hepatocarcinoma cell line through XBP1 splicing modulationPLOS ONEJanuary 17, 2023Lynda Bourebaba, Sai Santosh Babu Komakula, Christine Weiss, Nabil Adrar, Krzysztof Maryczdays using a Trypsin/EDTA solution (Gibco Carlsbad, CA, USA). Tunicamycin (Cayman Chemical, Cat. No: 11445, USA) was used to induce endoplasmic reticulum (ER) stress in cultured hepatocytes. Four testing, cell culture

(14) Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyesNature communicationsOctober 10, 2022Ikeda SI, Kurihara T, Jiang X, Miwa Y, Lee D, Serizawa N, Jeong H, Mori K, Katada Y, Kunimi H, et al.#: N0986), Ceapin-A7 (Sigma-Aldrich, Catalog #: SML2330), tunicamycin (Cayman Chemical, Catalog #: 11445), thapsigargin (Wako, Tokyo, Japan, Catalog #: 209-17281), CCT020312 (Millipore Corp, USA, Catalog #:

(15) A genome-wide CRISPR screen identifies DPM1 as a modifier of DPAGT1 deficiency and ER stressPLOS GeneticsSeptember 27, 2022Hans M. Dalton, Raghuvir Viswanatha, Roderick Brathwaite, Jae Sophia Zuno, Alexys R. Berman, Rebekah Rushforth, Stephanie E. Mohr, Norbert Perrimon, Clement Y. Chow(Thermo 16140071). Cell toxicity assay for tunicamycin sensitivity Tunicamycin (Cayman Chemical # 11445) dissolved in DMSO was serially diluted 2-fold into growth media in 96-well plates. Then, cells were

(16) De novo sphingolipid biosynthesis necessitates detoxification in cancer cellsCell reportsSeptember 27, 2022Spears ME, Lee N, Hwang S, Park SJ, Carlisle AE, Li R, Doshi MB, Armando AM, Gao J, Simin K, et al.(Millipore Sigma #474790) were dissolved in DMSO to stock concentrations of 10mM. Tunicamycin (Cayman Chemical #11445) was dissolved in DMSO to a stock concentration of 6mM. Cloning of CRISPR constructs Guide RNA sequences

(17) Polo-Like Kinase 2 Plays an Essential Role in Cytoprotection against MG132-Induced Proteasome Inhibition via Phosphorylation of Serine 19 in HSPB5International journal of molecular sciencesSeptember 24, 2022Ueda S, Nishihara M, Hioka Y, Yoshino KI, Yamada S, Yamanoue M, Shirai Y.(CS-0071, Chemscene LLC), MK2 inhibitor III (15943, Cayman Chemical, Ann Arbor, MI, USA), tunicamycin (11445, Cayman), streptavidin-peroxidase polymer (S2438, Sigma-Aldrich), streptavidin-Alexa Fluor 546 (S11225,

(18) Role of endoplasmic reticulum stress in impaired neonatal lung growth and bronchopulmonary dysplasiaPloS oneJanuary 1, 2022Pritchard KA Jr, Jing X, Teng M, Wells C, Jia S, Afolayan AJ, Jarzembowski J, Day BW, Naylor S, Hessner MJ, et al.Detection POD Kit (#11684817910) was from Roche Applied Science (Indianapolis, IN). Tunicamycin (Tun, #11445) was from Cayman Chemical (Ann Arbor, Michigan) and was freshly dissolved in dimethyl sulfoxide (DMSO)

(19) RNF13 Dileucine Motif Variants L311S and L312P Interfere with Endosomal Localization and AP-3 Complex AssociationCellsNovember 6, 2021Cabana VC, Bouchard AY, Sénécal AM, Ghilarducci K, Kourrich S, Cappadocia L, Lussier MP.induced in transfected HeLa cells using 1.25 µg/mL tunicamycin (Cayman Chemical, Ann Arbor, MI, USA, Cat# 11445), 1 µM thapsigargin (Cayman Chemical, Cat# 10522), or incubated with an equal volume of dimethyl sulfoxide

(20) Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's diseaseNature communicationsSeptember 6, 2021Hu D, Sun X, Magpusao A, Fedorov Y, Thompson M, Wang B, Lundberg K, Adams DJ, Qi X.(Houston, TX, USA). MG132 (13697), lactacystin (70980), epoxomicin (10007806), BFA (11038), tunicamycin (11445), and thapsigargin (10522) were purchased from Cayman Chemical (Ann Arbor, MI, USA). N-acetyl-calpastatin

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Tunicamycin Mixture from Cayman Chemical

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Cayman Chemical

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Tunicamycin Mixture from Cayman Chemical

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