Cyclopamine from Cayman Chemical

Product Specs
ItemCyclopamine
CompanyCayman Chemical
Price $132.00Supplier Page View Company Product Page
Catalog Number11321
Quantity10 mg
Research AreaCell Biology, Cell Signaling, Hedgehog Signaling
FormatA crystalline solid
Molecular Weight411.6
Purity≥95%
Storage-20
FormulaC27H41NO2
OriginUSA

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitroDevelopmental CellDecember 15, 2025Daniel Medina-Cano, Mohammed T. Islam, Veronika Petrova, Sanjana Dixit, Zerina Balic, Marty G. Yang, Matthias Stadtfeld, Emily S. Wong, Thomas VierbuchenChroman 1,MedChem Express,Cat#HY-15392 Collagenase Type IV,Gibco,Cat#17104019 Cyclopamine,Cayman Chemical,Cat#11321 DeepClear,Celexplorer,Cat#DC-201 Dimethyl sulfoxide (DMSO),Sigma-Aldrich,Cat#D2650 DMEM with glutamax,Gibco,Cat#10564029 DMEM/F12

(2) VISTA-FISH: Video Imaging with Spatial-Temporal Analysis by Fluorescent In Situ HybridizationbioRxivNovember 7, 2025Kun H. Lee, Mingjia Yao, Javid Ghaemmaghami, Cynthia J. DeLong, Neil Zhao, Jaimee Moline, Jonathan Sexton, Sami J. Barmada, Joshua D. Welch2 mM GlutaMAX, 1% NEAA, 20 ng/ml bFGF (PeproTech, 100-18B), and 2 uM cyclopamine (Cayman Chemical, 11321). NPCs were dissociated into single cells with Accutase, washed with DPBS, resuspended in NPC maintenance

(3) Robust Production of Parvalbumin Interneurons and Fast-Spiking Neurons from Human Medial Ganglionic Eminence OrganoidsbioRxivJuly 4, 2025Maria C. Varela, Miranda P. Walker, Jeyoon Bok, Emmanuel L. Crespo, Tyler Thenstedt, Leah Goldstein, Andrew M. Tidball, Jun Z. Li, Yukun Yuan, Lori L. Isom, et al.4126 XAV939,Cayman Chemical,Cat# 13596 SB-431542,Cayman Chemical,Cat# 13031 Cyclopamine,Cayman Chemical,Cat# 11321 L7 Passaging Solution,Lonza,Cat# FP-5013 CHIR99021,Cayman Chemical,Cat# 13122 SAG,Selleckchem,Cat#

(4) The sonic hedgehog signaling inhibitor cyclopamine improves pulmonary arterial hypertension via regulating the bone morphogenetic protein receptor 2 pathwayScientific reportsApril 11, 2025Jin Y, Mao F, Wang X, Zhang J, Gao Y, Fan Y.smooth muscle growth medium (SmGM, Lonza) and studied at passages 5–8. Varying concentrations of cyclopamine (11321, Cayman Chemical, Ann Arbor, MI, USA; 2.5, 5, or 10 µM), SHH-N (100 − 45, PeproTech, Cranbury, NJ, USA;

(5) Shh signaling directs dorsal ventral patterning in the regenerating X. tropicalis spinal cordDevelopmental BiologyApril 1, 2025Avery Angell Angell Swearer, Samuel Perkowski, Andrea Wills(http://www.xenbase.org/, RRID:SCR_003280)51 genome v10.0. Pharmacological Inhibition Cyclopamine (Cayman Chemical, 11321) was resuspended to a 10 mM stock in DMSO, and SAG (GLPBio, GC50135) to a 5 mM stock in DMSO. Uninjured

(6) Natural reversal of cavefish heart asymmetry is controlled by Sonic Hedgehog effects on the left-right organizerDevelopmentJuly 15, 2024Mandy Ng, Li Ma, Janet Shi, William R. Jefferysignaling in CF The Shh pathway was inhibited by treatment of CF-L/D embryos with 20 µM cyclopamine (11321, Cayman Chemical) or 2 µM SANT-1 (1974, Tocris) (Chen et al., 2002a, b). Stock solutions were prepared

(7) Deriving early single-rosette brain organoids from human pluripotent stem cellsStem Cell ReportsDecember 12, 2023Andrew M. Tidball, Wei Niu, Qianyi Ma, Taylor N. Takla, J. Clayton Walker, Joshua L. Margolis, Sandra P. Mojica-Perez, Roksolana Sudyk, Lu Deng, Shannon J. Moore, et al.(Cayman Chemical, 13031) (2 mL of media per well). Daily 75% media changes with 1 μM cyclopamine (Cayman Chemical, 11321) added began on day 1. On day 4, the monolayer was cut into squares using the StemPro EZ passage tool,

(8) A Shared Pathogenic Mechanism for Valproic Acid and SHROOM3 Knockout in a Brain Organoid Model of Neural Tube DefectsbioRxivApril 18, 2023Taylor N. Takla, Jinghui Luo, Roksolana Sudyk, Joy Huang, J. Clayton Walker, Neeta L. Vora, Jonathan Z. Sexton, Jack M. Parent, Andrew M. TidballmL of medium per well). 75% of this medium was changed daily with 1 μM cyclopamine (Cayman Chemical, 11321) added beginning on day 1. On day 4, the monolayer was cut into squares using the StemPro EZ passage

(9) Two-Phase Lineage Specification of Telencephalon Progenitors Generated From Mouse Embryonic Stem CellsFrontiers in Cell and Developmental BiologyApril 16, 2021Makoto Nasu, Shigeyuki Esumi, Jun Hatakeyama, Nobuaki Tamamaki, Kenji ShimamuraIC50 = 6.7 nM) exposure are described in the text and figures. The Shh antagonist cyclopamine (Cayman, 11321, IC50 = 24 nM) was added at 1 nM and the BMP inhibitor LDN193189 (Cayman, 11802, IC50 = 4.9 nM) at 10

(10) PDGFRA in vascular adventitial MSCs promotes neointima formation in arteriovenous fistula in chronic kidney diseaseJCI insightNovember 5, 2020Song K, Qing Y, Guo Q, Peden EK, Chen C, Mitch WE, Truong L, Cheng J.10100-147) were obtained from Invitrogen (Life Technologies). SAG (catalog 11914) and cyclopamine (catalog 11321) were obtained from Cayman Chemical. GANT61(G9048), MG132 (M8699), and NH4Cl (A9434) were obtained from

(11) Hedgehog signaling is required for endomesodermal patterning and germ cell development in the sea anemone Nematostella vectensiseLifeSeptember 24, 2020Cheng-Yi Chen, Sean A McKinney, Lacey R Ellington, Matthew C Gibson(Vismodegib, Cayman Chemical; Ann Arbor, MI; Cat. No. 13613) and Cyclopamine (Cayman Chemical; Cat. No. 11321) were diluted in DMSO as 50 mM and 10 mM stocks, respectively. These stocks were diluted 1:2000 in 12

(12) Protective effect of sonic hedgehog against oxidized low‑density lipoprotein‑induced endothelial apoptosis: Involvement of NF‑κB and Bcl‑2 signalingInternational journal of molecular medicineJune 1, 2020Huang H, Yu H, Lin L, Chen J, Zhu P.ddH2O. Cyclopamine, a hedgehog signaling inhibitor, was purchased from Cayman Chemical Company (cat. no. 11321). Pyrrolidine dithiocarbamate (PDTC) was purchased from Sigma-Aldrich; Merck KGaA (cat. no. P8765).

(13) Sequential specification of oligodendrocyte lineage cells by distinct levels of Hedgehog and Notch signalingDevelopmental BiologyDecember 1, 2018Andrew M. Ravanelli, Christina A. Kearns, Rani K. Powers, Yuying Wang, Jacob H. Hines, Maranda J. Donaldson, Bruce Appelthen kept at 28.5°C in the dark until imaging. Pharmacological inhibitor treatments Cyclopamine (Cat#11321, Cayman Chemical) was reconstituted in ethanol to make a 10 mM stock and stored at −20°C. LY411575 (Cat#4–0054,

(14) ScreenCube: A 3D Printed System for Rapid and Cost-Effective Chemical Screening in Adult ZebrafishZebrafishFebruary 1, 2018Adrian T. Monstad-Rios, Claire J. Watson, Ronald Y. Kwonstereomicroscope. Percent area regrowth was calculated as described previously.10 Cyclopamine (item No. 11321; Cayman Chemical Company) and dorsomorphin (item No. 11967; Cayman Chemical Company) were dissolved

(15) Motor neurons and oligodendrocytes arise from distinct cell lineages by progenitor recruitmentGenes & developmentDecember 1, 2015Ravanelli AM, Appel B.and P < 0.001 (***). Drug treatments For Smoothened inhibitor assays, cyclopamine (Cayman Chemical, 11321) was reconstituted in ethanol to make a 10 mM stock and stored at −20°C. Embryos were treated at 24

(16) Endothelial Cilia Are Essential for Developmental Vascular Integrity in ZebrafishJournal of the American Society of NephrologyApril 1, 2015Sowjanya Kallakuri, Jianxin A. Yu, Jade Li, Yuanyuan Li, Brant M. Weinstein, Stefania Nicoli, Zhaoxia Sunchanged to 59-ATGAGtGAgCAatTaAAgTTcATt-39. Cyclopamine was purchased from Cayman Chemicals (catalog no. 11321) and stored at 220°C. Dilutions were made to 25–30 mM using embryo medium containing 1% DMSO. Embryos

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Cyclopamine from Cayman Chemical

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Cayman Chemical

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Cyclopamine from Cayman Chemical

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