PCI 34051 from Cayman Chemical

Product Specs
ItemPCI 34051
CompanyCayman Chemical
Price $912.00Supplier Page View Company Product Page
Catalog Number10444
Quantity100 mg
FormatA crystalline solid
Molecular Weight296.3
Purity≥95%
TypeInhibitors
Research AreaApoptosis, Cancer, Cell Death, Epigenetics, Transcription, & Translation, Erasers, Histone Deacetylation
Storage-20
FormulaC17H16N2O3
OriginCHN

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) High-Density Lipoprotein Signaling via Sphingosine-1-Phosphate Receptors Safeguards Spontaneously Hypertensive Rats against Myocardial Ischemia/Reperfusion InjuryPharmaceuticsApril 3, 2024Aishah Al-Jarallah, Fawzi A. BabikerAnn Arbor, MI, USA), JTE-013 (S1PR2 antagonist, 1 µM, Cayman Chemical, Ann Arbor, MI, USA), or CAY-10444 (S1PR3 antagonist, 10 µM, Cayman Chemical, Ann Arbor, MI, USA). To test the role of intracellular signaling

(2) HDAC8 suppresses the epithelial phenotype and promotes EMT in chemotherapy-treated basal-like breast cancerClinical EpigeneticsDecember 1, 2022Garyfallia Pantelaiou-Prokaki, Iga Mieczkowska, Geske E. Schmidt, Sonja Fritzsche, Evangelos Prokakis, Julia Gallwas, Florian Wegwitztreatment Three cycles of 48-h treatment with PCI34051 (HDAC8 inhibitor, Cayman chemical, cat. no 10444) or TMP 195 (HDAC4 and HDAC7 inhibitor, Cayman chemical, cat. no 23242) were performed. 24 h after seeding,

(3) S1PR3, as a Core Protein Related to Ischemic Stroke, is Involved in the Regulation of Blood-Brain Barrier DamageFrontiers in pharmacologyJanuary 1, 2022Fan X, Chen H, Xu C, Wang Y, Yin P, Li M, Tang Z, Jiang F, Wei W, Song J, et al.the sham group were subjected to the same operation process except that the MCA was not occluded. CAY-10444 was purchased from the Cayman Company and was injected intraperitoneally into mice at 0.5 mg/kg during

(4) Hdac8 Inhibitor Alleviates Transverse Aortic Constriction-Induced Heart Failure in Mice by Downregulating Ace1Oxidative medicine and cellular longevityJanuary 1, 2022Zhao T, Kee HJ, Kee SJ, Jeong MH.of HDAC8 in the pathogenesis of heart failure. 2. Materials and Methods 2.1. Reagents PCI34051 (10444) was purchased from Cayman Chemical Company (Ann Arbor, MI, USA). Anti-Actb (sc-47778), anti-Nppb (sc-271185),

(5) Inhibiting Sphingosine 1-Phosphate Receptor Subtype 3 Attenuates Brain Damage During Ischemia-Reperfusion Injury by Regulating nNOS/NO and Oxidative StressFrontiers in neuroscienceJanuary 1, 2022Fan X, Chen H, Xu C, Wang Y, Yin P, Li M, Tang Z, Jiang F, Wei W, Song J, et al.mice were randomly assigned to 4 cages, and the average success rate of the model was over 90%.CAY-10444 was purchased from Cayman Company and was injected intraperitoneally into mice at 0.5 mg/kg during reperfusion

(6) Macrophage Sphingosine 1-Phosphate Receptor 2 Blockade Attenuates Liver Inflammation and Fibrogenesis Triggered by NLRP3 InflammasomeFrontiers in immunologyJanuary 1, 2020Hou L, Yang L, Chang N, Zhao X, Zhou X, Dong C, Liu F, Yang L, Li L.Junction, NJ, USA). W146 (10009109, S1PR1 antagonist), JTE-013(10009458, S1PR2 antagonist), and CAY-10444(10005033, S1PR3 antagonist) were from Cayman Chemical (Ann Arbor, MI). Animal Models Male ICR mice,

(7) Sphingosine 1-Phosphate Receptor Blockade Affects Pro-Inflammatory Bone Marrow-Derived Macrophages and Relieves Mouse Fatty Liver InjuryInternational Journal of Molecular SciencesSeptember 22, 2019Jingjing Yang et al.Histopaque-1077 and other common reagents were purchased from Sigma (St. Louis, MO, USA). The JTE-013 and CAY-10444 were obtained from Cayman Chemical (Ann Arbor, MI, USA). 4.2. Animal Model Male ICR mice, 31.0 ± 1.0

(8) Sphingosine 1-Phosphate (S1P)/S1P Receptor2/3 Axis Promotes Inflammatory M1 Polarization of Bone Marrow-Derived Monocyte/Macrophage via G(α)i/o/PI3K/JNK PathwayCellular Physiology and BiochemistryJanuary 9, 2018Jingjing Yang, Le Yang, Lei Tian, Xiaofang Ji, Lin Yang, Liying LiSigma-Aldrich (St. Louis, MO). S1PR1 antagonist W146, S1PR2 antagonist JTE-013 and S1PR3 antagonist CAY-10444 were from Cayman Chemical (Ann Arbor, MI). Pertussis toxin (PTX, G(a)i/o inhibitor), SB203580 (p38 inhibitor)

(9) The effect of sphingosine-1-phosphate on colonic smooth muscle contractility: Modulation by TNBS-induced colitisPLOS ONEMay 11, 2017Aishah Al-Jarallah, Mabayoje Oriowosoftware. Drugs solutions The following drugs were used in this study: S1P, SEW2871, W146, JTE-013 and CAY-10444, purchased from Cayman Chemical (MI, USA). Other drugs including nifedipine, thapsigargin, GF 109203X

(10) Sphingosine 1-Phosphate Receptor 2 and 3 Mediate Bone Marrow-Derived Monocyte/Macrophage Motility in Cholestatic Liver Injury in MiceScientific reportsSeptember 1, 2015Yang L, Han Z, Tian L, Mai P, Zhang Y, Wang L, Li L.Biosystems (Foster City, CA). S1P and dihydro-S1P (H2S1P) were from Biomol (Tebu, France). JTE-013 and CAY-10444 were from Cayman Chemical (Ann Arbor, MI). Anti-F4/80 antibody used for flow cytometry analysis was

(11) microRNA-148a dysregulation discriminates poor prognosis of hepatocellular carcinoma in association with USP4 overexpressionOncotargetMay 15, 2014Mi Jeong Heo, Young Mi Kim, Ja Hyun Koo, Yoon Mee Yang, Jihyun An, Sook-Kyung Lee, Seung Jin Lee, Kang Mo Kim, Joong-Won Park, Sang Geon KimW146 and VPC23019 were purchased from Avanti Polar Lipids (Alabaster, AL), whereas SEW2871 and CAY-10444 were from Cayman Chemical (Ann Arbor, MI). Applications of HCC patient samples Fifty nine paired samples

(12) Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor κB in BEAS-2B cellsPloS oneJanuary 1, 2014O'Sullivan MJ, Hirota N, Martin JG.S1P induced IL-8 release. Materials and Methods Reagents W 123 (10 µM), JTE 013 (1–10 µM), CAY 10444 (10 µM), specific inhibitors of S1PR1, S1PR2, S1PR3 respectively, S1P (0.1–10 µM), and the EGFR inhibitor

(13) Utilization of the Tango beta-arrestin recruitment technology for cell-based EDG receptor assay development and interrogationJ Biomol ScreenOctober 1, 2009Justin A. Wetter, Chetana Revankar, Bonnie J. HansonNJ), and FTY720-P was purchased from Toronto Research Chemicals (North York, Ontario). JTE-013 and CAY-10444 were purchased from Cayman Che mical (Ann Arbor, MI). All cell culture components, transfection reagents,

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PCI 34051 from Cayman Chemical

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Cayman Chemical

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PCI 34051 from Cayman Chemical

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