Description
An antiparasitic compound and a derivative of artemisinin; induces mortality in adult wild-type and pfatp6-mutant P. falciparum but the efficacy is decreased in the mutants (IC50s = 8.2 and 13.5 nM, respectively); reduces parasitemia in P. falciparum-infected monkeys and P. berghei-infected mice (CD50s = 7.1 and 55 mg/kg, respectively); reduces the worm burden of S. mansoni trematodes in mice at doses ranging from 200-500 mg/kg