FK-506 from Cayman Chemical

Product Specs
ItemFK-506
CompanyCayman Chemical
Price $544.00Supplier Page View Company Product Page
Catalog Number10007965
Quantity100 mg
Research AreaAdaptive Immunity, Calcium Mobilization, Cell Biology, Cell Signaling, Immunology & Inflammation, Immunosuppressants, Neuroscience
FormatA crystalline solid
Molecular Weight804
Purity≥99%
Storage-20
FormulaC44H69NO12
OriginCHN
TypeInhibitors

Specifications/Features

Information:
immunosuppressant immunosuppression inhibitor T cells activation cyclosporin A rapamycin Binding Proteins 12 FKBP12 calcium.calmodulin-dependent phosphatases calcineurins nitric oxides neurotoxicity neurotransmitter releases regulation Ca2+ Ca++ ryanodine inositols (1,4,5) triphosphates IP3 receptors

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Engineered basement membrane mimetic hydrogels to study mammary epithelial morphogenesis and invasionScience AdvancesSeptember 26, 2025Jane A. Baude, Megan D. Li, Sabrina M. Jackson, Abhishek Sharma, Daniella I. Walter, Ryan S. Stowersday postencapsulation. DMSO was used as a vehicle control for all inhibitors. FK506 (Cayman Chemical, 10007965) was used at a working concentration of 1 μM. PF-573228 (FAK inhibitor, Cayman Chemical) was used at

(2) Evaluating the Neuroprotective and Acetylcholinesterase Inhibitory Properties of Four Calcineurin Inhibitor Drugs: Tacrolimus, Pimecrolimus, Cyclosporin A, and VoclosporinMolecular NeurobiologySeptember 15, 2025Fatma Gonca Kocanci, Hamiyet Eciroglu Sarban, Fatma Yildizal. [45], with some modifications implemented. Various concentrations (0.01–10 μM) of Tac (FK506) (10007965, Cayman Chemical Company), Pim (SML1437; SIGMA ALDRICH), Csa (B1922 Apexbio), and Voc (FV28719-Biosynth)

(3) Engineered basement membrane mimetic hydrogels to study mammary epithelial morphogenesis and invasionbioRxivMarch 3, 2025Jane A. Baude, Megan D. Li, Sabrina M. Jackson, Abhishek Sharma, Daniella I. Walter, Ryan S. Stowerspost-encapsulation. DMSO was used as a vehicle control for all inhibitors. FK506 (Cayman Chemical, 10007965) was used at a working concentration of 1 μM. PF-573228 (FAK inhibitor, Cayman Chemical) was used at

(4) TRPM7’s Channel Activity Promotes the Pathogenesis of Abdominal Aortic AneurysmNature Cardiovascular ResearchFebruary 14, 2025Pengyu Zong, Cindy X. Li, Jianlin Feng, Zhichao Yue, Thushara Nethramangalath, Yangzhouyun Xie, Xin Qin, Mara Cicchetti, Yujun Cai, Evan Jellison, et al.Naltriben mesylate (TOCRIS, 0812); W-13 (hydrochloride) (Cayman chemical, 14277); FK-506 (Cayman chemical, 10007965); NS8593 (hydrochloride) (Cayman chemical, 29774); FTY720 Phosphate (Cayman chemical, 10008639); EGTA

(5) Validation of a mouse 3D gastruloid-based embryotoxicity assay in reference to the ICH S5(R3) guideline chemical exposure listReproductive ToxicologyApril 1, 2024Margaret Carrell Huntsman, Courtney Kehaulani Kurashima, Yusuke Marikawaaspirin,Cayman (32991),2 M (DMSO) Saxagliptin,,Cayman (23697),200 mM (DMSO) Tacrolimus (FK-506),,Cayman (10007965),20 mM (DMSO) Thalidomide,,Cayman (14610),500 mM (DMSO) Topiramate,,Cayman (13623),100 mM (DMSO) Tretinoin,All-trans

(6) The mitochondrial permeability transition pore activates the mitochondrial unfolded protein response and promotes agingeLifeSeptember 1, 2021Angeli S, Foulger A, Chamoli M, Peiris TH, Gerencser A, Shahmirzadi AA, Andersen J, Lithgow G.(trifluoromethoxycarbonylcyanidephenylhydrazone),Cayman Chemical,Item # 15218, "Chemical compound, drug",FK506 (tacrolimus),Cayman Chemical,Item # 10007965, "Chemical compound, drug",Tetramethylrhodamine methyl ester (perchlorate) (TMRM),Cayman Chemical,Item

(7) Nr4a1 and Nr4a3 Reporter Mice Are Differentially Sensitive to T Cell Receptor Signal Strength and DurationCell ReportsNovember 3, 2020Emma Jennings, Thomas A.E. Elliot, Natasha Thawait, Shivani Kanabar, Juan Carlos Yam-Puc, Masahiro Ono, Kai-Michael Toellner, David C. Wraith, Graham Anderson, David Bending151561 Cyclosporin A,Cell Guidance Systems,Cat# SM43; CAS: 59865-13-3 FK506 (Tacrolimus),Cayman Chemical,Cat# 10007965; CAS: 59865-13-3 PD 0325901,Cayman Chemical,Cat# 13034; CAS: 391210-10-9 DMSO,Sigma Aldrich,Cat# D2650;

(8) Tacrolimus‐induced hypomagnesemia and hypercalciuria requires FKBP12 suggesting a role for calcineurinPhysiological ReportsJanuary 8, 2020Brittany D. K. Gratreak, Elizabeth A. Swanson, Rebecca A. Lazelle, Sabina K. Jelen, Joost Hoenderop, René J. Bindels, Chao‐Ling Yang, David H. Ellisonand NCX1 protein abundance. 2.2 Tacrolimus Powdered tacrolimus (Cayman Chemical Company Catalog #10007965) was dissolved in a 3:1 solution of DMSO:TWEEN20 to 30 mg/ml. This solution was further diluted with

(9) Quantitative analysis of protein interaction network dynamics in yeastMolecular Systems BiologyJuly 15, 2017Albi Celaj et al.(AUCcondition−AUCcontrol)/AUCcontrol. Chemical reagents and environmental conditions FK506 (catalog no. 10007965) was purchased from Cayman Chemical. Methotrexate (catalog no. M4010), doxorubicin (catalog no. D1515),

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FK-506 from Cayman Chemical

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Cayman Chemical

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FK-506 from Cayman Chemical

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