Description
A CysLT1 receptor antagonist (IC50 = 0.014 µM in a cell-based calcium mobilization assay); selective for CysLT1 over CysLT2 receptors (IC50 = 58 µM); inhibits LTD4-induced mucus secretion in isolated guinea pig trachea (IC50 = 0.6 µM); inhibits ovalbumin-induced increases in tracheal mucus secretion in ovalbumin-sensitized guinea pigs by 65% at 5 µM; inhibits LTD4-induced bronchoconstriction in anesthetized guinea pigs (ED50 = 61 nmol/kg, i.v.)