Description
An analgesic and anticonvulsant; inhibits current-induced signal transmission and reduces glutamatergic excitatory postsynaptic potentials in isolated rat striatal neurons (EC50s = 320.4 and 96.8 µM, respectively); inhibits glutamate-induced membrane depolarization in isolated rat striatal neurons at 100 or 300 µM; decreases mechanical and cold allodynia in rats at 60 mg/kg; reduces plasma levels of Tnf-α and Il-1β and increases sciatic nerve levels of GSH and decreases sciatic nerve levels of MDA in a rat model of vincristine-induced neuropathic pain; decreases the number of MES-induced seizures in rats (ED50 = 14.8 mg/kg)