PHCCC from Tocris Bioscience, a Bio-Techne Brand | Biocompare.com

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PHCCC

Potent group I mGlu antagonist
PHCCC

Cat.No. 1027 - PHCCC C17H14N2O3 CAS No. 179068-02-1

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Tocris Bioscience, a Bio-Techne Brand for
PHCCC

Description

Potent group I mGlu antagonist

Product Specs
ItemPHCCC
CompanyTocris Bioscience, a Bio-Techne Brand
Price $203.00Supplier Page View Company Product Page
Catalog Number1027/10
Quantity10 mg (also 50 mg)
Purity98%
Molecular Weight294.31
Molecule NameN-Phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide
FormulaC17H14N2O3
StorageStore at RT

Specifications/Features

Sizes Available: 10 mg (also 50 mg)

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Allosteric modulation of metabotropic glutamate receptor 4 activates IDO1-dependent, immunoregulatory signaling in dendritic cellsNeuropharmacologyMarch 1, 2016Volpi C, Mondanelli G, Pallotta MT, Vacca C, Iacono A, Gargaro M, Albini E, Bianchi R, Belladonna ML, Celanire S, et al.

(2) Glial metabotropic glutamate receptor-4 increases maturation and survival of oligodendrocytesFrontiers in cellular neuroscienceJanuary 1, 2014Spampinato SF, Merlo S, Chisari M, Nicoletti F, Sortino MA.

(3) High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell deathProceedings of the National Academy of Sciences of the United States of AmericaApril 3, 2012Fox JT, Sakamuru S, Huang R, Teneva N, Simmons SO, Xia M, Tice RR, Austin CP, Myung K.

(4) Antiparkinsonian potential of targeting group III metabotropic glutamate receptor subtypes in the rodent substantia nigra pars reticulataBritish journal of pharmacologyFebruary 1, 2012Broadstock M, Austin PJ, Betts MJ, Duty S.

(5) Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkinsonian animal modelJournal of medicinal chemistryNovember 10, 2011Jones CK, Engers DW, Thompson AD, Field JR, Blobaum AL, Lindsley SR, Zhou Y, Gogliotti RD, Jadhav S, Zamorano R, et al.

(6) mGluR(1) Receptors Contribute to Non-Purinergic Slow Excitatory Transmission to Submucosal VIP Neurons of Guinea-Pig IleumFrontiers in neuroscienceJanuary 1, 2009Foong JP, Bornstein JC.

(7) Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4Molecular pharmacologyNovember 1, 2008Niswender CM, Johnson KA, Weaver CD, Jones CK, Xiang Z, Luo Q, Rodriguez AL, Marlo JE, de Paulis T, Thompson AD, et al.

(8) A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulatorsMolecular pharmacologyAugust 1, 2006Hemstapat K, de Paulis T, Chen Y, Brady AE, Grover VK, Alagille D, Tamagnan GD, Conn PJ.

(9) Neutrophil-derived glutamate regulates vascular endothelial barrier functionThe Journal of biological chemistryApril 26, 2002Collard CD, Park KA, Montalto MC, Alapati S, Buras JA, Stahl GL, Colgan SP.

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