GSK 650394 from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemGSK 650394
CompanyTocris Bioscience, a Bio-Techne Brand
Price $305.00Supplier Page View Company Product Page
Catalog Number3572/10
Quantity10 mg (also 50 mg)
Purity97%
Molecular Weight382.45
Molecule Name2-Cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl-benzoic acid
FormulaC25H22N2O2
StorageStore at RT

Specifications/Features

Sizes Available: 10 mg (also 50 mg)

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) DNA hypomethylator phenotype reprograms glutamatergic network in receptor tyrosine kinase gene-mutated glioblastomaActa neuropathologica communicationsMarch 13, 2024Harachi M, Masui K, Shimizu E, Murakami K, Onizuka H, Muragaki Y, Kawamata T, Nakayama H, Miyata M, Komori T, et al.Bisindolylmaleimide I (Bis-I) (Santa Cruz; Cat# sc-24003), GSK 650394 (Tocris Bioscience, Bristol, UK; Cat# 3572/10), GSKJ4 (Sigma; Cat# T1952), GSK126 (MedChem Express, Monmouth Junction, NJ; Cat# HY-13470), GSK2256098

(2) SGK2, 14-3-3, and HUWE1 Cooperate to Control the Localization, Stability, and Function of the Oncoprotein PTOV1Molecular cancer research : MCRFebruary 1, 2022Pennington KL, McEwan CM, Woods J, Muir CM, Pramoda Sahankumari AG, Eastmond R, Balasooriya ER, Egbert CM, Kaur S, Heaton T, et al.

(3) Serum- and glucocorticoid- inducible kinase 2, SGK2, is a novel autophagy regulator and modulates platinum drugs response in cancer cellsOncogeneOctober 1, 2020Ranzuglia V, Lorenzon I, Pellarin I, Sonego M, Dall'Acqua A, D'Andrea S, Lovisa S, Segatto I, Coan M, Polesel J, et al.

(4) Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAMMolecular cancer research : MCRAugust 1, 2020Harachi M, Masui K, Honda H, Muragaki Y, Kawamata T, Cavenee WK, Mischel PS, Shibata N.

(5) Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived EicosanoidsCellJune 25, 2020Koundouros N, Karali E, Tripp A, Valle A, Inglese P, Perry NJS, Magee DJ, Anjomani Virmouni S, Elder GA, Tyson AL, et al.

(6) Salt Sensing by Serum/Glucocorticoid-Regulated Kinase 1 Promotes Th17-like Inflammatory Adaptation of Foxp3⁺ Regulatory T CellsCell reportsFebruary 4, 2020Yang YH, Istomine R, Alvarez F, Al-Aubodah TA, Shi XQ, Takano T, Thornton AM, Shevach EM, Zhang J, Piccirillo CA.

(7) Bidirectional Regulation between NDRG1 and GSK3β Controls Tumor Growth and Is Targeted by Differentiation Inducing Factor-1 in GlioblastomaCancer researchJanuary 15, 2020Ito H, Watari K, Shibata T, Miyamoto T, Murakami Y, Nakahara Y, Izumi H, Wakimoto H, Kuwano M, Abe T, et al.

(8) mTORC2 links growth factor signaling with epigenetic regulation of iron metabolism in glioblastomaThe Journal of biological chemistryDecember 20, 2019Masui K, Harachi M, Ikegami S, Yang H, Onizuka H, Yong WH, Cloughesy TF, Muragaki Y, Kawamata T, Arai N, et al.

(9) EAE-induced upregulation of mitochondrial MnSOD is associated with increases of mitochondrial SGK1 and Tom20 protein in the mouse kidney cortexThe journal of physiological sciences : JPSSeptember 1, 2019Hira S, Packialakshmi B, Zhou X.

(10) Axonal and Myelin Neuroprotection by the Peptoid BN201 in Brain InflammationNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeuticsJuly 1, 2019Villoslada P, Vila G, Colafrancesco V, Moreno B, Fernandez-Diez B, Vazquez R, Pertsovskaya I, Zubizarreta I, Pulido-Valdeolivas I, Messeguer J, et al.

(11) Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activationMolecular visionJanuary 1, 2019Messerschmidt L, Fischer S, Wiedemann P, Bringmann A, Hollborn M.

(12) Methods for High-throughput Drug Combination Screening and Synergy ScoringMethods in molecular biology (Clifton, N.J.)January 1, 2018He L, Kulesskiy E, Saarela J, Turunen L, Wennerberg K, Aittokallio T, Tang J.

(13) Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cellsMolecular visionJanuary 1, 2018Kleiner J, Hollborn M, Wiedemann P, Bringmann A.

(14) Urokinase-type plasminogen activator (uPA) is critical for progression of tuberous sclerosis complex 2 (TSC2)-deficient tumorsThe Journal of biological chemistryDecember 15, 2017Stepanova V, Dergilev KV, Holman KR, Parfyonova YV, Tsokolaeva ZI, Teter M, Atochina-Vasserman EN, Volgina A, Zaitsev SV, Lewis SP, et al.

(15) Signaling Cascade Involved in Rapid Stimulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by DexamethasoneInternational journal of molecular sciencesAugust 19, 2017Bossmann M, Ackermann BW, Thome UH, Laube M.

(16) Dietary Salt Exacerbates Experimental ColitisJournal of immunology (Baltimore, Md. : 1950)August 1, 2017Tubbs AL, Liu B, Rogers TD, Sartor RB, Miao EA.

(17) The serum and glucocorticoid-regulated protein kinases (SGK) stimulate bovine herpesvirus 1 and herpes simplex virus 1 productive infectionVirus researchAugust 15, 2016Kook I, Jones C.

(18) Phosphoinositide 3-kinase inhibitors induce DNA damage through nucleoside depletionProceedings of the National Academy of Sciences of the United States of AmericaJuly 26, 2016Juvekar A, Hu H, Yadegarynia S, Lyssiotis CA, Ullas S, Lien EC, Bellinger G, Son J, Hok RC, Seth P, et al.

(19) Role of SGK1 for fatty acid uptake, cell survival and radioresistance of NCI-H460 lung cancer cells exposed to acute or chronic cycling severe hypoxiaRadiation oncology (London, England)June 1, 2016Matschke J, Wiebeck E, Hurst S, Rudner J, Jendrossek V.

(20) Excess salt exacerbates blood-brain barrier disruption via a p38/MAPK/SGK1-dependent pathway in permanent cerebral ischemiaScientific reportsNovember 9, 2015Zhang T, Fang S, Wan C, Kong Q, Wang G, Wang S, Zhang H, Zou H, Sun B, Sun W, et al.

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GSK 650394

GSK 650394 from Tocris Bioscience, a Bio-Techne Brand

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Specifications/Features

Tocris Bioscience, a Bio-Techne Brand

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GSK 650394 from Tocris Bioscience, a Bio-Techne Brand

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