MPEP hydrochloride from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemMPEP hydrochloride
CompanyTocris Bioscience, a Bio-Techne Brand
Price $208.00Supplier Page View Company Product Page
Catalog Number1212/10
Quantity10 mg (also 50 mg)
Purity98%
Molecular Weight229.71
Molecule Name2-Methyl-6-(phenylethynyl)pyridine hydrochloride
FormulaC14H11N.HCl
StorageDesiccate at +4°C

Specifications/Features

Sizes Available: 10 mg (also 50 mg)

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Genetic rescue of disrupted synaptic protein interaction network dynamics following SYNGAP1 reactivationMolecular & Cellular ProteomicsJune 26, 2026Vera Stamenkovic, Felicia Harsh, Breann Kniffen, Gavin Rumbaugh, Stephen E.P. SmithTocris, 0190, 40 μM; Nimodipine, Tocris, 0600, 1 μM; LY-367385, Sigma, L4420, 100 μM; MPEP, Tocris, 1212, 10 μM). Type I mGluR agonist DHPG (Tocris, 0805; 100 μM) was dissolved in HEPES-aCSF in the presence of

(2) The Synaptic and Intrinsic Cellular Mechanisms of Persistent Firing in Neurogliaform CellsBiomoleculesNovember 15, 2025Shiyuan Chen, Xiaoshan Chen, Jianwen Zhou, Jinzhao Wang, Kaiyuan Li, Wenyuan Xie, Cheng Long, Gangyi Wufollowing drugs: 20 μΜ 2-methyl-6-(phenylethynyl) pyridine (MPEP, mGlu5 receptor blocker, Tocris, Cat. No. 1212), 10 μΜ LY367385 (mGlu1 receptor blocker, Tocris, Cat. No. 1237), 100 μΜ 2-amino-5-phosphonovalerate (APV,

(3) SRC family kinase inhibition rescues molecular and behavioral phenotypes, but not protein interaction network dynamics, in a mouse model of Fragile X syndromeMolecular psychiatryMay 1, 2024Stamenkovic V, Lautz JD, Harsh FM, Smith SEP.Tocris, 0190, 40 μM; Nimodipine, Tocris, 0600, 1 μM; LY-367385, Sigma, L4420, 100 μM; MPEP, Tocris, 1212, 10 μM). Type I mGluR agonist DHPG (Tocris, 0805; 100 μM) was dissolved in HEPES-aCSF in the presence of

(4) Peripheral and Central Impact of Methionine Source and Level on Growth Performance, Circulating Methionine Levels and Metabolism in Broiler ChickensAnimals (Basel)June 12, 2023Craig W. Maynard, Elizabeth Gilbert, Frances Yan, Mark A. Cline, Sami DridiCharles, MO, USA). Diets were analyzed for total amino acids and HMTBa (Novus Methods RM113; RM115; 121210-6, Rev. 4) (Table 2). Weekly pen weights and feed consumption were recorded. Body weights were determined

(5) Synaptic protein interaction networks encode experience by assuming stimulus-specific and brain-region-specific statesCell reportsNovember 30, 2021Lautz JD, Tsegay KB, Zhu Z, Gniffke EP, Welsh JP, Smith SEP.Tocris, 0190, 40 μM; Nimodipine, Tocris, 0600, 1 μM; LY-367385, Sigma, L4420, 100 μM; MPEP, Tocris, 1212, 10 μM). Type I mGluR agonist DHPG (Tocris, 0805; 100 μM) was dissolved in HEPES-aCSF in the presence of

(6) Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformationsCell reportsAugust 31, 2021Nasrallah C, Cannone G, Briot J, Rottier K, Berizzi AE, Huang CY, Quast RB, Hoh F, Banères JL, Malhaire F, et al.Glutamax,Life Technologie,31966021 Freestyle serum-Free Medium,Life Technologie,12338018 MPEP,Bio-techne,Cat#1212/10 Tritiated MPEP,Isobio,ART 1209-250 μCi VU0424465,"Nasrallah et al., 2018",N/A LY341495 disodium salt,Bio-techne,Cat#4062/1 L-Quisqualic acid

(7) Synapse-specific opioid modulation of thalamo-cortico-striatal circuitseLifeMay 17, 2019Birdsong WT, Jongbloets BC, Engeln KA, Wang D, Scherrer G, Mao T.

(8) The Probability of Neurotransmitter Release Governs AMPA Receptor Trafficking via Activity-Dependent Regulation of mGluR1 Surface ExpressionCell ReportsDecember 26, 2018Thomas M. Sanderson et al.HB0398 YM 298198 hydrochloride,Tocris/HelloBio,Cat# 2448/10 or HB0664 MPEP hydrochloride,Tocris,Cat# 1212/10 NMDA,Tocris,Cat# 0114/50 4-Aminopyridine,Tocris,Cat# 0940/100 TBOA,Tocris,Cat# 1223/10 or HB0258 Picrotoxin,Tocris/HelloBio,Cat#

(9) Dopamine Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of Dopamine and GlutamateCell reportsDecember 11, 2018Cai Y, Ford CP.

(10) A group I metabotropic glutamate receptor controls synaptic gain between rods and rod bipolar cells in the mouse retinaPhysiological reportsOctober 1, 2018Hellmer CB, Clemons MR, Nawy S, Ichinose T.

(11) Astrocytic Activation Generates De Novo Neuronal Potentiation and Memory EnhancementCellJune 28, 2018Adamsky A, Kol A, Kreisel T, Doron A, Ozeri-Engelhard N, Melcer T, Refaeli R, Horn H, Regev L, Groysman M, et al.

(12) Neuronal Glutamate Transporters Control Dopaminergic Signaling and Compulsive BehaviorsThe Journal of neuroscience : the official journal of the Society for NeuroscienceJanuary 24, 2018Bellini S, Fleming KE, De M, McCauley JP, Petroccione MA, D'Brant LY, Tkachenko A, Kwon S, Jones LA, Scimemi A.phenylethynyl)pyridine hydrochloride (MPEP) were purchased from Tocris Bioscience (catalog #1044, 0105/10, 1237/10, and 1212/10) and Hello Bio (catalog #HB0443, HB0251, HB0398, HB0426). All other chemicals were purchased from Millipore

(13) Drebrin Isoforms Critically Regulate NMDAR- and mGluR-Dependent LTD InductionFrontiers in cellular neuroscienceJanuary 1, 2018Yasuda H, Kojima N, Hanamura K, Yamazaki H, Sakimura K, Shirao T.

(14) LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition BalanceNeuronAugust 16, 2017Hashimotodani Y, Nasrallah K, Jensen KR, Chávez AE, Carrera D, Castillo PE.

(15) Metabotropic glutamate receptor 5 mediates the suppressive effect of 6-OHDA-induced model of Parkinson's disease on liver cancerPharmacological researchJuly 1, 2017Xi SS, Bai XX, Gu L, Bao LH, Yang HM, An W, Wang XM, Zhang H.

(16) The medullary dorsal reticular nucleus as a relay for descending pronociception induced by the mGluR5 in the rat infralimbic cortexNeuroscienceMay 4, 2017David-Pereira A, Sagalajev B, Wei H, Almeida A, Pertovaara A, Pinto-Ribeiro F.

(17) Long-Term Potentiation at the Mossy Fiber-Granule Cell Relay Invokes Postsynaptic Second-Messenger Regulation of Kv4 ChannelsThe Journal of neuroscience : the official journal of the Society for NeuroscienceNovember 2, 2016Rizwan AP, Zhan X, Zamponi GW, Turner RW.

(18) Estradiol Facilitation of Cocaine Self-Administration in Female Rats Requires Activation of mGluR5eNeuroSeptember 1, 2016Martinez LA, Gross KS, Himmler BT, Emmitt NL, Peterson BM, Zlebnik NE, Foster Olive M, Carroll ME, Meisel RL, Mermelstein PG.

(19) Acute inhibition of mGluR5 disrupts behavioral flexibilityNeurobiology of learning and memoryApril 1, 2016Sethna F, Wang H.

(20) Mechanisms of tau and Aβ-induced excitotoxicityBrain researchMarch 1, 2016Pallo SP, DiMaio J, Cook A, Nilsson B, Johnson GVW.

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