PD 173074 from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemPD 173074
CompanyTocris Bioscience, a Bio-Techne Brand
Price $306.00Supplier Page View Company Product Page
Catalog Number3044/10
Purity98%
Molecular Weight523.67
Molecule NameN-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea
FormulaC28H41N7O3
StorageStore at +4°C
Quantity10 mg (also 50 mg)

Specifications/Features

Sizes Available: 10 mg (also 50 mg)

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Identification of novel neuroprotectants against vincristine-induced neurotoxicity in iPSC-derived neuronsCellular and molecular life sciences : CMLSJuly 27, 2024Petrova V, Snavely AR, Splaine J, Zhen S, Singh B, Pandey R, Chen K, Cheng A, Hermawan C, Barrett LB, et al.µM CHIR-98014, 2 µM A83-01, 1 µM DBZ (Tocris, cat no. 4489/10) and 25 nM PD173074 (Tocris, cat no. 3044/10) for further 11 days. Nocispheres were then collected and dissociated using the MACS Embrioid Body Dissociation

(2) Nociceptor-immune interactomes reveal insult-specific immune signatures of painNature immunologyJuly 1, 2024Jain A, Gyori BM, Hakim S, Jain A, Sun L, Petrova V, Bhuiyan SA, Zhen S, Wang Q, Kawaguchi R, et al.µM CHIR-98014, 2 µM A83-01, 1 µM DBZ (Tocris, cat. no. 4489/10) and 25 nM PD173074 (Tocris, cat. no. 3044/10). On day 14 from the onset of differentiation, nocispheres were dissociation using the MACS EB dissociation

(3) Principles of signaling pathway modulation for enhancing human naive pluripotency inductionCell stem cellSeptember 2, 2021Bayerl J, Ayyash M, Shani T, Manor YS, Gafni O, Massarwa R, Kalma Y, Aguilera-Castrejon A, Zerbib M, Amir H, et al.Medchem,1509 Human IGF1,Peprotech,100-11 Forskolin,TOCRIS,1099 FGF receptor inhibitor FGFRi PD173074,TOCRIS,3044/10 TGF receptor inhibitor TGFRi/ALKi A83-01,Axon Medchem,1421 Kenopaullone,Sigma,422000 DOT1Li SGC0946,Sigma,SML1107 Human

(4) The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to BranchesCell reportsNovember 12, 2019Brosig A, Fuchs J, Ipek F, Kroon C, Schrötter S, Vadhvani M, Polyzou A, Ledderose J, van Diepen M, Holzhütter HG, et al.

(5) IFT80 is required for stem cell proliferation, differentiation, and odontoblast polarization during tooth developmentCell death & diseaseJanuary 25, 2019Yuan X, Cao X, Yang S.

(6) Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome EditingStem CellsJanuary 1, 2019Adkar SS, Wu CL, Willard VP, Dicks A, Ettyreddy A, Steward N, Bhutani N, Gersbach CA, Guilak F.

(7) Ciliary neurotrophic factor stimulates cardioprotection and the proliferative activity in the adult zebrafish heartNPJ Regenerative medicineJanuary 1, 2019Bise T, de Preux Charles AS, Jaźwińska A.

(8) Self-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonismNature communicationsNovember 7, 2017Takata N, Sakakura E, Eiraku M, Kasukawa T, Sasai Y.

(9) FGF8 and SHH substitute for anterior-posterior tissue interactions to induce limb regenerationNatureMay 19, 2016Nacu E, Gromberg E, Oliveira CR, Drechsel D, Tanaka EM.

(10) Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineagesNature communicationsFebruary 3, 2016Lichtenberger BM, Mastrogiannaki M, Watt FM.

(11) A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiationCellular and molecular life sciences : CMLSSeptember 1, 2015Benzina S, Pitaval A, Lemercier C, Lustremant C, Frouin V, Wu N, Papine A, Soussaline F, Romeo PH, Gidrol X.

(12) Increased FGF1-FGFRc expression in idiopathic pulmonary fibrosisRespiratory researchJuly 3, 2015MacKenzie B, Korfei M, Henneke I, Sibinska Z, Tian X, Hezel S, Dilai S, Wasnick R, Schneider B, Wilhelm J, et al.

(13) Fibroblast surface-associated FGF-2 promotes contact-dependent colorectal cancer cell migration and invasion through FGFR-SRC signaling and integrin αvβ5-mediated adhesionOncotargetJune 10, 2015Knuchel S, Anderle P, Werfelli P, Diamantis E, Rüegg C.

(14) The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinomaBMC cancerFebruary 25, 2015Saito S, Morishima K, Ui T, Hoshino H, Matsubara D, Ishikawa S, Aburatani H, Fukayama M, Hosoya Y, Sata N, et al.

(15) A Molecular atlas of Xenopus respiratory system developmentDevelopmental dynamics : an official publication of the American Association of AnatomistsJanuary 1, 2015Rankin SA, Thi Tran H, Wlizla M, Mancini P, Shifley ET, Bloor SD, Han L, Vleminckx K, Wert SE, Zorn AM.

(16) Inhibition of G9a Histone Methyltransferase Converts Bone Marrow Mesenchymal Stem Cells to Cardiac Competent ProgenitorsStem cells internationalJanuary 1, 2015Yang J, Kaur K, Ong LL, Eisenberg CA, Eisenberg LM.

(17) Generation of the epicardial lineage from human pluripotent stem cellsNature biotechnologyOctober 1, 2014Witty AD, Mihic A, Tam RY, Fisher SA, Mikryukov A, Shoichet MS, Li RK, Kattman SJ, Keller G.

(18) PD173074, a selective FGFR inhibitor, reverses MRP7 (ABCC10)-mediated MDRActa pharmaceutica Sinica. BJune 1, 2014Anreddy N, Patel A, Sodani K, Kathawala RJ, Chen EP, Wurpel JN, Chen ZS.

(19) Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-βProceedings of the National Academy of Sciences of the United States of AmericaMay 27, 2014Wiener Z, Band AM, Kallio P, Högström J, Hyvönen V, Kaijalainen S, Ritvos O, Haglund C, Kruuna O, Robine S, et al.

(20) Prolonged FGF signaling is necessary for lung and liver induction in XenopusBMC developmental biologySeptember 18, 2012Shifley ET, Kenny AP, Rankin SA, Zorn AM.

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PD 173074

PD 173074 from Tocris Bioscience, a Bio-Techne Brand

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Specifications/Features

Tocris Bioscience, a Bio-Techne Brand

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PD 173074 from Tocris Bioscience, a Bio-Techne Brand

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