Tunicamycin from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemTunicamycin
CompanyTocris Bioscience, a Bio-Techne Brand
Price $249.00Supplier Page View Company Product Page
Catalog Number3516/10
Quantity10 mg
Molecular Weight844.95
Molecule NameTunicamycin from Streptomyces sp
FormulaC39H64N4O16 (tunicamycin C, n=10)
Purity98%
StorageStore at +4°C

Specifications/Features

Sizes Available: 10 mg

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) METTL9 sustains vertebrate neural development primarily via non-catalytic functionsNat CommunAugust 1, 2025Azzurra Codino, Luca Spagnoletti, Claudia Olobardi, Alessandro Cuomo, Helena Santos-Rosa, Martina Palomba, Natasha Margaroli, Stefania Girotto, Rita Scarpelli, Shi-Lu Luan, et al.respective Results sections and Figures. Mettl9Deg mESCs were plated the day before tunicamycin (Tocris, #3516/10) treatment. 0.5 μg/ml tunicamycin was added to the media and after 9 hrs cells were collected for SDS-PAGE

(2) Maximizing protein production by keeping cells at optimal secretory stress levels using real-time control approachesNature communicationsMay 25, 2023Sosa-Carrillo S, Galez H, Napolitano S, Bertaux F, Batt G.

(3) Mannose metabolism inhibition sensitizes acute myeloid leukaemia cells to therapy by driving ferroptotic cell deathNature communicationsApril 14, 2023Woodley K, Dillingh LS, Giotopoulos G, Madrigal P, Rattigan KM, Philippe C, Dembitz V, Magee AMS, Asby R, van de Lagemaat LN, et al.

(4) Soluble Klotho protects against glomerular injury through regulation of ER stress responseCommunications biologyFebruary 22, 2023Charrin E, Dabaghie D, Sen I, Unnersjö-Jess D, Möller-Hackbarth K, Burmakin M, Mencke R, Zambrano S, Patrakka J, Olauson H.

(5) Staufen Impairs Autophagy in NeurodegenerationAnnals of neurologyFebruary 1, 2023Paul S, Dansithong W, Gandelman M, Figueroa KP, Zu T, Ranum LPW, Scoles DR, Pulst SM.

(6) Hepatic SEL1L-HRD1 ER-associated degradation regulates systemic iron homeostasis via ceruloplasminProceedings of the National Academy of Sciences of the United States of AmericaJanuary 10, 2023Thepsuwan P, Bhattacharya A, Song Z, Hippleheuser S, Feng S, Wei X, Das NK, Sierra M, Wei J, Fang D, et al.

(7) Systemic lipolysis promotes physiological fitness in Drosophila melanogasterAgingAugust 30, 2022Shang L, Aughey E, Kim H, Heden TD, Wang L, Najt CP, Esch N, Brunko S, Abrahante JE, Macchietto M, et al.

(8) The Sec61 translocon is a therapeutic vulnerability in multiple myelomaEMBO molecular medicineMarch 7, 2022Domenger A, Choisy C, Baron L, Mayau V, Perthame E, Deriano L, Arnulf B, Bories JC, Dadaglio G, Demangel C.

(9) Integrated stress response restricts macrophage necroptosisLife science allianceJanuary 1, 2022Place DE, Samir P, Malireddi RS, Kanneganti TD.

(10) HRD1-mediated METTL14 degradation regulates m(6)A mRNA modification to suppress ER proteotoxic liver diseaseMolecular cellDecember 16, 2021Wei J, Harada BT, Lu D, Ma R, Gao B, Xu Y, Montauti E, Mani N, Chaudhuri SM, Gregory S, et al.34076 SuperSignal West Femto Maximum Sensitivity Substrate,Thermo,Cat# 34095 Tunicamycin,Tocris,Cat# 351610 Poly(I:C),Sigma,Cat# 31852-29-6 Cycloheximide,Sigma,Cat# C7698 Actinomycin D,Millipore,Cat# 50-76-0 MG-132,Sigma,Cat#

(11) Targeting the IRE1α/XBP1 Endoplasmic Reticulum Stress Response Pathway in ARID1A-Mutant Ovarian CancersCancer researchOctober 15, 2021Zundell JA, Fukumoto T, Lin J, Fatkhudinov N, Nacarelli T, Kossenkov AV, Liu Q, Cassel J, Hu CA, Wu S, et al.

(12) Colchicine acts selectively in the liver to induce hepatokines that inhibit myeloid cell activationNature metabolismApril 1, 2021Weng JH, Koch PD, Luan HH, Tu HC, Shimada K, Ngan I, Ventura R, Jiang R, Mitchison TJ.

(13) A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivityJCI insightMarch 8, 2021Barghout SH, Aman A, Nouri K, Blatman Z, Arevalo K, Thomas GE, MacLean N, Hurren R, Ketela T, Saini M, et al.

(14) MINPP1 prevents intracellular accumulation of the chelator inositol hexakisphosphate and is mutated in Pontocerebellar HypoplasiaNature communicationsNovember 30, 2020Ucuncu E, Rajamani K, Wilson MSC, Medina-Cano D, Altin N, David P, Barcia G, Lefort N, Banal C, Vasilache-Dangles MT, et al.manufacturer’s instructions. For a positive control, cells are treated with tunicamycin (10 µg/ml, 3516/10, Biotechne) for 6 h to induce apoptosis (data not shown). For quantiﬁcation analysis, a minimum of 5

(15) Probing natural variation of IRE1 expression and endoplasmic reticulum stress responses in Arabidopsis accessionsScientific reportsNovember 5, 2020Afrin T, Seok M, Terry BC, Pajerowska-Mukhtar KM.intensity and 40% relative humidity). 0.15 μg/mL or 0.30 μg/mL of Tunicamycin (Tm) (Tocris Bioscience; 3516/10) were used as a chemical ER stressor. 7 days old seedlings were transferred to liquid half-strength

(16) Antagonistic relationship between the unfolded protein response and myocardin-driven transcription in smooth muscleJournal of cellular physiologyOctober 1, 2020Zhu B, Daoud F, Zeng S, Matic L, Hedin U, Uvelius B, Rippe C, Albinsson S, Swärd K.

(17) Endoplasmic Reticulum Stress in Subepithelial Myofibroblasts Increases the TGF-β1 Activity That Regulates Fibrosis in Crohn's DiseaseInflammatory bowel diseasesMay 12, 2020Li C, Grider JR, Murthy KS, Bohl J, Rivet E, Wieghard N, Kuemmerle JF.

(18) Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stresseLifeAugust 27, 2019Shemorry A, Harnoss JM, Guttman O, Marsters SA, Kőműves LG, Lawrence DA, Ashkenazi A.

(19) A CASPR1-ATP1B3 protein interaction modulates plasma membrane localization of Na⁺/K⁺-ATPase in brain microvascular endothelial cellsThe Journal of biological chemistryApril 19, 2019Zhang SH, Liu DX, Wang L, Li YH, Wang YH, Zhang H, Su ZK, Fang WG, Qin XX, Shang DS, et al.

(20) High N-glycan multiplicity is critical for neuronal adhesion and sensitizes the developing cerebellum to N-glycosylation defecteLifeOctober 12, 2018Medina-Cano D, Ucuncu E, Nguyen LS, Nicouleau M, Lipecka J, Bizot JC, Thiel C, Foulquier F, Lefort N, Faivre-Sarrailh C, et al.New England BioLabs P0704L Chemical compound, drug Tamoxifen Sigma H6278 1 mM Chemical compound, drug Tunicamycin BioTechne 3516/10 0.01 mg/mL Chemical compound, drug WATER-18O, 97 ATOM % 18O Sigma 329878 Glycoproteomics reagent Commercial assay

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Tunicamycin

Tunicamycin from Tocris Bioscience, a Bio-Techne Brand

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Specifications/Features

Tocris Bioscience, a Bio-Techne Brand

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Tunicamycin from Tocris Bioscience, a Bio-Techne Brand

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