(-)-Bicuculline methochloride from Tocris Bioscience, a Bio-Techne Brand

Product Specs
Item(-)-Bicuculline methochloride
CompanyTocris Bioscience, a Bio-Techne Brand
Price $173.00Supplier Page View Company Product Page
Catalog Number0131/10
Quantity10 mg (also 50 mg)
Purity98%
Molecular Weight417.85
Molecule Name[R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium chloride
FormulaC21H20ClNO6
StorageStore at RT

Specifications/Features

Sizes Available: 10 mg (also 50 mg)

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Metabolic regulation of visual acuitySci AdvJune 27, 2025Douglas Emery, Eric Vukmanic, Yekai Wang, Mark Eminhizer, Fuhua Wang, Xiaoqin Lu, Wei Wang, Ashwini Kini, Yao Chen, Enzo Fortuny, et al.(L-AP4; L-APB; pH neutralized to 7.3) or 5 mM bicuculline (Tocris Biosciences; cat. numbers 1224/10 and 0131/10) was injected intravitreally in WT or RP littermates. Using a 30-gauge needle, 200 μl was injected 4.5

(2) Expression of GAD2 in excitatory neurons projecting from the ventrolateral periaqueductal gray to the locus coeruleusiScienceJune 21, 2024Erika K. Harding, Zizhen Zhang, Julia Canet-Pons, Sierra Stokes-Heck, Tuan Trang, Gerald W. Zamponicitrate,Alomone,Cat#T-550 4-AP (4-aminopyridine),Millipore Sigma,Cat#A-0152 Bicuculline methochloride,Tocris,Cat#0131/10 DNQX,Tocris,Cat#0189/10 QX 314 chloride,Tocris,Cat#2313/50 ,, Experimental models: Organisms/strains,Experimental models

(3) Projection-dependent heterogeneity of cerebellar granule cell calcium responsesMolecular brainMarch 31, 2021Rhee JK, Park H, Kim T, Yamamoto Y, Tanaka-Yamamoto K.were added to the extracellular ACSF before and during the imaging. Inhibitors used were bicuculline (#0131, 10 μM), AP5 (#0106, 100 μM), CNQX (#1045, 25 μM), 7Cl (#3697, 50 μM), CGP (#1245, 50 μM), DL-TBOA (#1223, 50

(4) Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavioreLifeSeptember 21, 2020Pati S, Saba K, Salvi SS, Tiwari P, Chaudhari PR, Verma V, Mukhopadhyay S, Kapri D, Suryavanshi S, Clement JP, et al.

(5) Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term DepressionCell reportsJuly 2, 2019Wagner W, Lippmann K, Heisler FF, Gromova KV, Lombino FL, Roesler MK, Pechmann Y, Hornig S, Schweizer M, Polo S, et al.

(6) CAST/ELKS Proteins Control Voltage-Gated Ca²⁺ Channel Density and Synaptic Release Probability at a Mammalian Central SynapseCell reportsJuly 10, 2018Dong W, Radulovic T, Goral RO, Thomas C, Suarez Montesinos M, Guerrero-Given D, Hagiwara A, Putzke T, Hida Y, Abe M, et al.

(7) Activity-Dependent Degradation of the Nascentome by the Neuronal Membrane ProteasomeMolecular cellJuly 5, 2018Ramachandran KV, Fu JM, Schaffer TB, Na CH, Delannoy M, Margolis SS.,Cell Signaling Technology,Cat# 2194S Precision Plus Standards,Bio-Rad,Cat# 1610374 Bicuculline,Tocris Bioscience,Cat# 013110; CAS: 53552-05-9 Cycloheximide,Sigma-Aldrich,Cat# C1988; CAS: 66-81-9 Puromycin,Sigma-Aldrich,Cat#

(8) Alternative 3' UTRs Modify the Localization, Regulatory Potential, Stability, and Plasticity of mRNAs in Neuronal CompartmentsNeuronMay 2, 2018Tushev G, Glock C, Heumüller M, Biever A, Jovanovic M, Schuman EM.

(9) Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18NeuronAugust 2, 2017Lai Y, Choi UB, Leitz J, Rhee HJ, Lee C, Altas B, Zhao M, Pfuetzner RA, Wang AL, Brose N, et al.

(10) Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate ReleaseNeuronApril 19, 2017Sigler A, Oh WC, Imig C, Altas B, Kawabe H, Cooper BH, Kwon HB, Rhee JS, Brose N.

(11) Potentiation of Synaptic GluN2B NMDAR Currents by Fyn Kinase Is Gated through BDNF-Mediated Disinhibition in Spinal Pain ProcessingCell reportsDecember 6, 2016Hildebrand ME, Xu J, Dedek A, Li Y, Sengar AS, Beggs S, Lombroso PJ, Salter MW.

(12) Absence of plateau potentials in dLGN cells leads to a breakdown in retinogeniculate refinementThe Journal of neuroscience : the official journal of the Society for NeuroscienceFebruary 25, 2015Dilger EK, Krahe TE, Morhardt DR, Seabrook TA, Shin HS, Guido W.

(13) High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neuronsNeuronFebruary 4, 2015Choe KY, Han SY, Gaub P, Shell B, Voisin DL, Knapp BA, Barker PA, Brown CH, Cunningham JT, Bourque CW.

(14) Protein tyrosine phosphatase receptor type R is required for Purkinje cell responsiveness in cerebellar long-term depressionMolecular brainJanuary 9, 2015Erkens M, Tanaka-Yamamoto K, Cheron G, Márquez-Ruiz J, Prigogine C, Schepens JT, Nadif Kasri N, Augustine GJ, Hendriks WJ.

(15) Basal adenosine modulates the functional properties of AMPA receptors in mouse hippocampal neurons through the activation of A1R A2AR and A3RFrontiers in cellular neuroscienceJanuary 1, 2015Di Angelantonio S, Bertollini C, Piccinin S, Rosito M, Trettel F, Pagani F, Limatola C, Ragozzino D.

(16) Reduction in focal ictal activity following transplantation of MGE interneurons requires expression of the GABAA receptor α4 subunitFrontiers in cellular neuroscienceJanuary 1, 2015Jaiswal MK, Keros S, Zhao M, Inan M, Schwartz TH, Anderson SA, Homanics GE, Goldstein PA.

(17) T-type channel blockade impairs long-term potentiation at the parallel fiber-Purkinje cell synapse and cerebellar learningProceedings of the National Academy of Sciences of the United States of AmericaDecember 10, 2013Ly R, Bouvier G, Schonewille M, Arabo A, Rondi-Reig L, Léna C, Casado M, De Zeeuw CI, Feltz A.

(18) Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptorsMolecular pharmacologyJanuary 1, 2013Rojas A, Wetherington J, Shaw R, Serrano G, Swanger S, Dingledine R.

(19) High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell deathProceedings of the National Academy of Sciences of the United States of AmericaApril 3, 2012Fox JT, Sakamuru S, Huang R, Teneva N, Simmons SO, Xia M, Tice RR, Austin CP, Myung K.

(20) Lack of kinase regulation of canonical transient receptor potential 3 (TRPC3) channel-dependent currents in cerebellar Purkinje cellsThe Journal of biological chemistryFebruary 24, 2012Nelson C, Glitsch MD.

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