Crizotinib from Tocris Bioscience, a Bio-Techne Brand | Biocompare.com

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Crizotinib

Potent c-MET/ALK inhibitor
Crizotinib

Crizotinib

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Tocris Bioscience, a Bio-Techne Brand for
Crizotinib

Description

Potent c-MET/ALK inhibitor

Product Specs
ItemCrizotinib
CompanyTocris Bioscience, a Bio-Techne Brand
Price $371.00Supplier Page View Company Product Page
Catalog Number4368/10
Quantity10 mg (also 50 mg)
Purity98%
Molecular Weight450.34
Molecule Name3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine
FormulaC21H22Cl2FN5O
StorageStore at +4°C

Specifications/Features

Sizes Available: 10 mg (also 50 mg)

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) The tyrosine kinase inhibitor crizotinib influences blood glucose and mRNA expression of GLUT4 and PPARs in the heart of rats with experimental diabetesCanadian journal of physiology and pharmacologyJune 1, 2021Hadova K, Mesarosova L, Kralova E, Doka G, Krenek P, Klimas J.

(2) Synergistic activity of agents targeting growth factor receptors, CDKs and downstream signaling molecules in a panel of pancreatic cancer cell lines and the identification of antagonistic combinations: Implications for future clinical trials in pancreatic cancerOncology reportsDecember 1, 2020Khan T, Seddon AM, Dalgleish AG, Khelwatty S, Ioannou N, Mudan S, Modjtahedi H.

(3) Establishment and characterization of patient-derived organoids from a young patient with cervical clear cell carcinomaCancer scienceSeptember 1, 2019Maru Y, Tanaka N, Ebisawa K, Odaka A, Sugiyama T, Itami M, Hippo Y.

(4) Deep analysis of acquired resistance to FGFR1 inhibitor identifies MET and AKT activation and an expansion of AKT1 mutant cellsOncotargetJuly 31, 2018Gimenez-Xavier P, Pros E, Aza A, Moran S, Tonda R, Esteve-Codina A, Dabad M, Sanchez-Cespedes M.

(5) Genomic and Molecular Screenings Identify Different Mechanisms for Acquired Resistance to MET Inhibitors in Lung Cancer CellsMolecular cancer therapeuticsJuly 1, 2017Gimenez-Xavier P, Pros E, Bonastre E, Moran S, Aza A, Graña O, Gomez-Lopez G, Derdak S, Dabad M, Esteve-Codina A, et al.

(6) Synergistic effects of various Her inhibitors in combination with IGF-1R, C-MET and Src targeting agents in breast cancer cell linesScientific reportsJune 21, 2017Stanley A, Ashrafi GH, Seddon AM, Modjtahedi H.

(7) Crizotinib, a MET inhibitor, inhibits growth, migration, and invasion of breast cancer cells in vitro and synergizes with chemotherapeutic agentsOncoTargets and therapyJanuary 1, 2017Ayoub NM, Al-Shami KM, Alqudah MA, Mhaidat NM.

(8) Crosstalk between bone marrow-derived myofibroblasts and gastric cancer cells regulates cancer stemness and promotes tumorigenesisOncogeneOctober 13, 2016Zhu L, Cheng X, Shi J, Jiacheng L, Chen G, Jin H, Liu AB, Pyo H, Ye J, Zhu Y, et al.

(9) Deregulated hepsin protease activity confers oncogenicity by concomitantly augmenting HGF/MET signalling and disrupting epithelial cohesionOncogeneApril 7, 2016Tervonen TA, Belitškin D, Pant SM, Englund JI, Marques E, Ala-Hongisto H, Nevalaita L, Sihto H, Heikkilä P, Leidenius M, et al.

(10) Acquired resistance to anti-EGFR mAb ICR62 in cancer cells is accompanied by an increased EGFR expression, HER-2/HER-3 signalling and sensitivity to pan HER blockersBritish journal of cancerSeptember 29, 2015Khelwatty SA, Essapen S, Seddon AM, Fan Z, Modjtahedi H.

(11) ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53Nature chemical biologyJuly 1, 2012Sullivan KD, Padilla-Just N, Henry RE, Porter CC, Kim J, Tentler JJ, Eckhardt SG, Tan AC, DeGregori J, Espinosa JM.

(12) Multiple mutations and bypass mechanisms can contribute to development of acquired resistance to MET inhibitorsCancer researchFebruary 1, 2011Qi J, McTigue MA, Rogers A, Lifshits E, Christensen JG, Jänne PA, Engelman JA.

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