TPCA-1 from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemTPCA-1
CompanyTocris Bioscience, a Bio-Techne Brand
Price $354.00Supplier Page View Company Product Page
Catalog Number2559/10
Purity97%
Molecular Weight279.29
Molecule Name2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide
FormulaC12H10FN3O2S
StorageStore at -20°C
Quantity10 mg

Specifications/Features

Sizes Available: 10 mg

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi networkImmunityDecember 13, 2022Schmacke NA, O'Duill F, Gaidt MM, Szymanska I, Kamper JM, Schmid-Burgk JL, Mädler SC, Mackens-Kiani T, Kozaki T, Chauhan D, et al.Scientific,Cat# 10639-011 Takinib,"Selleck Chemicals, Houston, TX",Cat# S8663 TPCA-1,R&D Systems,Cat# 2559/10 Trypsin,Sigma-Aldrich,Cat# T6567 b-Estradiol,Sigma-Aldrich,Cat# E8875 Critical commercial assays,Critical

(2) CAR T Cells Targeting MISIIR for the Treatment of Ovarian Cancer and Other Gynecologic MalignanciesMolecular therapy : the journal of the American Society of Gene TherapyFebruary 5, 2020Rodriguez-Garcia A, Sharma P, Poussin M, Boesteanu AC, Minutolo NG, Gitto SB, Omran DK, Robinson MK, Adams GP, Simpkins F, et al.

(3) Distinct and overlapping functions of glutathione peroxidases 1 and 2 in limiting NF-κB-driven inflammation through redox-active mechanismsRedox biologyJanuary 1, 2020Koeberle SC, Gollowitzer A, Laoukili J, Kranenburg O, Werz O, Koeberle A, Kipp AP.

(4) Small molecules that inhibit TNF signalling by stabilising an asymmetric form of the trimerNature communicationsDecember 19, 2019O'Connell J, Porter J, Kroeplien B, Norman T, Rapecki S, Davis R, McMillan D, Arakaki T, Burgin A, Fox Iii D, et al.

(5) A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancerNature communicationsApril 5, 2017Betancur PA, Abraham BJ, Yiu YY, Willingham SB, Khameneh F, Zarnegar M, Kuo AH, McKenna K, Kojima Y, Leeper NJ, et al.

(6) Early spatiotemporal-specific changes in intermediate signals are predictive of cytotoxic sensitivity to TNFα and co-treatmentsScientific reportsMarch 8, 2017Loo LH, Bougen-Zhukov NM, Tan WC.

(7) NEMO regulates a cell death switch in TNF signaling by inhibiting recruitment of RIPK3 to the cell death-inducing complex IICell death & diseaseAugust 25, 2016Pescatore A, Esposito E, Draber P, Walczak H, Ursini MV.

(8) Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytesJournal of neuroinflammationAugust 22, 2016O'Sullivan SA, Gasparini F, Mir AK, Dev KK.

(9) A highly conserved NF-κB-responsive enhancer is critical for thymic expression of Aire in miceEuropean journal of immunologyDecember 1, 2015Haljasorg U, Bichele R, Saare M, Guha M, Maslovskaja J, Kõnd K, Remm A, Pihlap M, Tomson L, Kisand K, et al.

(10) Breaking resistance of pancreatic cancer cells to an attenuated vesicular stomatitis virus through a novel activity of IKK inhibitor TPCA-1VirologyNovember 1, 2015Cataldi M, Shah NR, Felt SA, Grdzelishvili VZ.

(11) IKK2 inhibition using TPCA-1-loaded PLGA microparticles attenuates laser-induced choroidal neovascularization and macrophage recruitmentPloS oneJanuary 1, 2015Gaddipati S, Lu Q, Kasetti RB, Miller MC, Lu Q, Trent JO, Kaplan HJ, Li Q.

(12) Regulation of large conductance Ca2+-activated K+ (BK) channel β1 subunit expression by muscle RING finger protein 1 in diabetic vesselsThe Journal of biological chemistryApril 11, 2014Yi F, Wang H, Chai Q, Wang X, Shen WK, Willis MS, Lee HC, Lu T.

(13) NF-κB and STAT1 control CXCL1 and CXCL2 gene transcriptionAmerican journal of physiology. Endocrinology and metabolismJanuary 15, 2014Burke SJ, Lu D, Sparer TE, Masi T, Goff MR, Karlstad MD, Collier JJ.

(14) IKK2 inhibition attenuates laser-induced choroidal neovascularizationPloS oneJanuary 1, 2014Lu H, Lu Q, Gaddipati S, Kasetti RB, Wang W, Pasparakis M, Kaplan HJ, Li Q.

(15) Regulation of the CCL2 gene in pancreatic β-cells by IL-1β and glucocorticoids: role of MKP-1PloS oneJanuary 1, 2012Burke SJ, Goff MR, Updegraff BL, Lu D, Brown PL, Minkin SC Jr, Biggerstaff JP, Zhao L, Karlstad MD, Collier JJ.

(16) TNFR1 and TNFR2 regulate the extrinsic apoptotic pathway in myeloma cells by multiple mechanismsCell death & diseaseAugust 18, 2011Rauert H, Stühmer T, Bargou R, Wajant H, Siegmund D.

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TPCA-1

TPCA-1 from Tocris Bioscience, a Bio-Techne Brand

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Specifications/Features

Tocris Bioscience, a Bio-Techne Brand

Citations (16)

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TPCA-1 from Tocris Bioscience, a Bio-Techne Brand

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