D-AP5 from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemD-AP5
CompanyTocris Bioscience, a Bio-Techne Brand
Price $108.00Supplier Page View Company Product Page
Catalog Number0106/1
Quantity1 mg (also 10 mg, 50 mg, 100 mg)
Purity98%
Molecular Weight197.13
Molecule NameD-(-)-2-Amino-5-phosphonopentanoic acid
FormulaC5H12NO5P
StorageStore at RT

Specifications/Features

Sizes Available: 1 mg (also 10 mg, 50 mg, 100 mg)

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Hippocampal pyramidal cells of the CA1 region are not a major target of the thalamic nucleus reuniensPLoS BiolOctober 13, 2025Lilya Andrianova, Paul J. Banks, Clair A. Booth, Erica S. Brady, Gabriella Margetts-Smith, Shivali Kohli, Jonathan Cavanagh, Zafar I. Bashir, Chris J. McBain, Michael T. Craigcycle. Drugs and chemicals CGP55845 (Catalogue # 1248), DNQX (Catalogue # 2312/10), D-AP5 (Catalogue # 0106/1), and picrotoxin (Catalogue # 1128) were purchased from Tocris Bioscience, and all other chemicals were

(2) Oxytocin Improves Autistic Behaviors by Positively Shifting GABA Reversal Potential via NKCC1 in Early-Postnatal-StageAdv Sci (Weinh)April 30, 2025Zi-Hui Wang, Chang Xu, Yao-Yao Ma, Wei-Xuan Xue, Hao-Yuan Wang, Lin-Yao Fan, Chen-Yu Zhang, Liang Li, Xiao-Yang Zhang, Jing-Ning Zhu, et al.pipette solution in the presence of D‐APV (50 µm; Tocris Bioscience, Bristol, UK, cat. number: No. 0106/1) and NBQX (20 µm; Tocris Bioscience, Bristol, UK, cat. number: No. 0373/10), with or without TTX (0.3

(3) Identification of a Subpopulation of Astrocyte Progenitor Cells in the Neonatal Subventricular Zone: Evidence that Migration is Regulated by Glutamate SignalingNeurochem ResJanuary 9, 2025Zila Martinez-Lozada, Alain M. Guillem, Isabella Song, Michael V. Gonzalez, Hajime Takano, Esha Parikh, Jeffrey D. Rothstein, Mary E. Putt, Michael B. Robinsondizocilpine) (Tocris Cat#0924/10, [44]) or 100 µM D-(-)−2-amino-5-phosphonopentanoic acid (D-AP5) (Tocris Cat#0106/1, [45, 46]), AMPA and KA receptor antagonists: 10 µM 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline

(4) Synaptic rearrangement of NMDA receptors controls memory engram formation and malleability in the cortexScience AdvancesAugust 30, 2024Benjamin Bessières, Julien Dupuis, Laurent Groc, Bruno Bontempi, Olivier Nicolestopped 3 days before retrieval testing. Drugs d-2-amino-5-phosphonovalerate (AP5) (catalog number: 0106/1; Tocris, Bristol, UK) was prepared as a stock solution of 5 μg/μl in aCSF (catalog number: 3525; Tocris,

(5) Humid heat environment causes anxiety-like disorder via impairing gut microbiota and bile acid metabolism in miceNature CommunicationsJuly 7, 2024Huandi Weng, Li Deng, Tianyuan Wang, Huachong Xu, Jialin Wu, Qinji Zhou, Lingtai Yu, Boli Chen, Li’an Huang, Yibo Qu, et al.2,3-dihydroxy-6-nitro-7-sulfamoyl-benzoquinoxaline (NBQX, 0373/10, Tocris) and 50 μM D-(-)-2-amino-5-phosphonopentanoic acid (D-AP5, 0106/1, Tocris) solutions in flowing ACSF and a KCl-filled pipette (140 mM KCl, 10 mM HEPES, 0.2 mM EGTA, 4

(6) Nr4a1 regulates cell-specific transcriptional programs in inhibitory GABAergic interneuronsNeuronJune 19, 2024Huang M, Pieraut S, Cao J, de Souza Polli F, Roncace V, Shen G, Ramos-Medina C, Lee H, Maximov A.Peptides, and Recombinant Proteins","Chemicals, Peptides, and Recombinant Proteins" ,, APV,Tocris,Cat#01061 CNQX,Tocris,Cat#01045 Picrotoxin,Tocris,Cat#1128 Tetrodotoxin,Tocris,Cat#4368289 DTT,Sigma,Cat#646563 cOmplete™

(7) Increases in anterograde axoplasmic transport in neurons of the hyper‐glutamatergic, glutamate dehydrogenase 1 (Glud1) transgenic mouse: Effects of glutamate receptors on transportJournal of NeurochemistryMay 1, 2024Phil Lee, Jieun Kim, In‐Young Choi, Ranu Pal, Dongwei Hui, Joanne K. Marcario, Mary L. Michaelis, Elias K. Michaelis(AMP-PNP; cat. no. 10102547001), were from Sigma-Aldrich; 2-amino-phosphonopentanoic acid (2-AP5; cat. no. 0106/1) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQx; cat. no. 0190/10) from TOCRIS; and recombinant cholera

(8) Distinct effects of AMPAR subunit depletion on spatial memoryiScienceNovember 17, 2023Eltokhi A, Bertocchi I, Rozov A, Jensen V, Borchardt T, Taylor A, Proenca CC, Rawlins JNP, Bannerman DM, Sprengel R.Bioscience,N/A "(2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline)NBQX disodium salt",Tocris,Cat# 1044 (D-2-amino-5-phosphonovalerate) D-APV,Tocris,Cat# 0106 "(1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochlorid)GYKI 52466 dihydrochloride",Tocris,Cat#

(9) Maintenance of a short-lived protein required for long-term memory involves cycles of transcription and local translationNeuronJuly 1, 2023Sulagna Das, Pablo J. Lituma, Pablo E. Castillo, Robert H. Singerrecombinant proteins","Chemicals, peptides, and recombinant proteins" D-APV,Tocris Bioscience,Cat# 0106/1 TTX,Tocris Bioscience,Cat# 1069/1 Picrotoxin,Tocris Bioscience,Cat# 1128 Anisomycin,Tocris Bioscience,Cat#

(10) Ultrafast (400 Hz) network oscillations induced in mouse barrel cortex by optogenetic activation of thalamocortical axonseLifeMay 9, 2023Hang Hu, Rachel E Hostetler, Ariel Agmoncompound, drug",CNQX,Tocris,Cat. no. 1045/1,20 μM "Chemical compound, drug",D-AP5 (APV),Tocris,Cat. no. 0106/1,30 μM "Chemical compound, drug",Gabazine (SR 95531 hydrobromide),Tocris,Cat. no. 1262/10,20 μM

(11) A Parabrachial-to-Amygdala Circuit That Determines Hemispheric Lateralization of Somatosensory ProcessingBiological PsychiatryFebruary 1, 2023Heather N. Allen, Sarah Chaudhry, Veronica M. Hong, Lakeisha A. Lewter, Ghanshyam P. Sinha, Yarimar Carrasquillo, Bradley K. Taylor, Benedict J. Kolber(rat),Genscript,RP11090, Chemical Compound or Drug,CGRP (rat),Genscript,RP11095, Chemical Compound or Drug,AP-5,Tocris,0106/1, Chemical Compound or Drug,NBQX,Tocris,0373/10, Commercial Assay Or Kit,cAMP ELISA,Cell Biolabs,STA-500, Commercial

(12) Cell-type-specific integration of feedforward and feedback synaptic inputs in the posterior parietal cortexNeuronNovember 1, 2022Daniel J. Rindner, Archana Proddutur, Gyorgy Lurproteins" Tetrodotoxin citrate,Tocris,Cat. #1069/1 Mibefradil dihydrochloride,Tocris,Cat. #2198/10 D-AP5,Tocris,Cat. #0106/1 Picrotoxin,Tocris,Cat. #1128/1G NBQX disodium salt,Tocris,Cat. #1044/1 QX 314 Bromide,HelloBio,Cat.

(13) Transformation of an early-established motor circuit during maturation in zebrafishCell ReportsApril 12, 2022Irene Pallucchi, Maria Bertuzzi, Jennifer Carlisle Michel, Adam C. Miller, Abdeljabbar El El ManiraN-methyl-D-aspartate (NMDA) receptors antagonist D-(–)-2-amino-5-phosphonoic acid; (AP-5, 100 μM, Tocris, Cat# 0106/1), the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxaline

(14) Plasticity of olfactory bulb inputs mediated by dendritic NMDA-spikes in rodent piriform cortexeLifeOctober 26, 2021Amit Kumar, Edi Barkai, Jackie Schillerdrug",MNI-Caged-L-glutamate,Tocris Bioscience,Cat.#: 1490/10,5–10 mM "Chemical compound, drug",D-AP5,Tocris Bioscience,Cat.#: 0106/1,50 µM "Chemical compound, drug",Baclofen,Tocris Bioscience,Cat.#: 0796/10,100 µM "Software, algorithm",Igor

(15) Voltage-Gated Potassium Channels Ensure Action Potential Shape Fidelity in Distal AxonsThe Journal of neuroscience : the official journal of the Society for NeuroscienceJune 23, 2021Gonzalez Sabater V, Rigby M, Burrone J.

(16) Highly redundant neuropeptide volume co-transmission underlying episodic activation of the GnRH neuron dendroneLifeJanuary 19, 2021Liu X, Yeo SH, McQuillan HJ, Herde MK, Hessler S, Cheong I, Porteous R, Herbison AE.μM "Chemical compound, drug",D-2-Amino-5-phosphonopentanoic acid sodium salt (D-AP5),Tocris,Cat#: 0106/1,50 μM "Chemical compound, drug",DL-2-Amino-5-phosphonopentanoic acid sodium salt (DL-AP5),Tocris,Cat#:

(17) Nucleus Accumbens Tac1-Expressing Neurons Mediate Stress-Induced Anhedonia-like Behavior in MiceCell reportsNovember 3, 2020He ZX, Yin YY, Xi K, Xing ZK, Cao JB, Liu TY, Liu L, He XX, Yu HL, Zhu XJ.

(18) Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent mannerNature communicationsOctober 9, 2020Dorst MC, Tokarska A, Zhou M, Lee K, Stagkourakis S, Broberger C, Masmanidis S, Silberberg G.

(19) Functional Dissection of Basal Ganglia Inhibitory Inputs onto Substantia Nigra Dopaminergic NeuronsCell reportsSeptember 15, 2020Evans RC, Twedell EL, Zhu M, Ascencio J, Zhang R, Khaliq ZM.

(20) Axonal mechanisms mediating γ-aminobutyric acid receptor type A (GABA-A) inhibition of striatal dopamine releaseeLifeSeptember 1, 2020Kramer PF, Twedell EL, Shin JH, Zhang R, Khaliq ZM.

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D-AP5

D-AP5 from Tocris Bioscience, a Bio-Techne Brand

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Specifications/Features

Tocris Bioscience, a Bio-Techne Brand

Citations (404)

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D-AP5 from Tocris Bioscience, a Bio-Techne Brand

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