(+/-)-U-50488 hydrochloride from Tocris Bioscience, a Bio-Techne Brand

Product Specs
Item(+/-)-U-50488 hydrochloride
CompanyTocris Bioscience, a Bio-Techne Brand
Price $214.00Supplier Page View Company Product Page
Catalog Number0495/25
Quantity25 mg
Purity99%
Molecular Weight405.79
Molecule Nametrans-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride
FormulaC19H26Cl2N2O.HCl
StorageStore at RT

Sizes Available: 25 mg

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(1) The claustrum-prelimbic cortex circuit through dynorphin/κ-opioid receptor signaling underlies depression-like behaviors associated with social stress etiologyNature communicationsNovember 30, 2023Wang YJ, Zan GY, Xu C, Li XP, Shu X, Yao SY, Xu XS, Qiu X, Chen Y, Jin K, et al.Ibotenic acid (I2765) were purchased from Sigma-Aldrich. Zoletil was bought from Virbac. U50,488H (0495/25) was purchased from Tocris. nor-BNI (ab120078) was bought from Abcam. Bicuculline (abs812832) was bought

(2) Agonists Specific for κ-Opioid Receptor Induces Apoptosis of HCC Cells Through Enhanced Endoplasmic Reticulum StressFrontiers in oncologyJanuary 1, 2022Tan M, Wang H, Gao C, Jiang Z, Yin Y, Xing R, Hu L, Xu J, Zhang M, Xie Y.Industries) and 1% penicillin-streptomycin. Drugs and Treatment U50488 hydrochloride (U50488h, cat. no.0495/25), a specific agonist of KOR, was purchased from Tocris Bioscience Co., Ltd (Bristol, England); morphine Hydrochloride

(3) κ‑opioid receptor agonist U50488H attenuates postoperative cognitive dysfunction of cardiopulmonary bypass rats through the PI3K/AKT/Nrf2/HO‑1 pathwayMolecular Medicine ReportsFebruary 23, 2021Jianing Fan, Long Li, Pengxia Qu, Yugang Diao, Yingjie Sunmaintained for 1 h. Rats in the U50488H group were intravenously injected with U50488H (1.5 mg/kg, cat. no. 0495/25; Tocris Bioscience) before CPB surgery. Rats in the ZnPP and LY294002 groups were first intravenously

(5) κ‑opioid receptor agonists may alleviate intestinal damage in cardiopulmonary bypass rats by inhibiting the NF‑κB/HIF‑1α pathwayExperimental and Therapeutic MedicineApril 23, 2020Xiaoyan Zhang, Yingjie Sun, Dandan Song, Yugang Diaothe exception of those in the sham group. In group K, an intravenous injection of 1.5 mg/kg U50488H (cat. no. 0495/25; Tocris Bioscience) was administered prior to the bypass. In group NK, an intravenous injection of 1.5

(6) The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRseLifeJanuary 31, 2020Thibaut Laboute et al.or reference Identifiers Additional Chemical compound, drug U50488H Tocris Bioscience, Bristol, UK Cat# 0495/25 Material Mithras2 LB 943 Monochromator Multimode Microplate Reader Berthold Technologies GmbH and

(7) Kappa opioid receptor agonists improve postoperative cognitive dysfunction in rats via the JAK2/STAT3 signaling pathwayInternational journal of molecular medicineNovember 1, 2019Li X, Sun Y, Jin Q, Song D, Diao Y.the K group, the rats were administered with an intravenous injection of U50488H (1.5 mg/kg, cat. no. 0495/25, Tocris Bioscience, Bristol, UK) 30 min before the CPB assay; in the NK group, an intravenous injection

(9) In vivo brain GPCR signaling elucidated by phosphoproteomicsScience (New York, N.Y.)June 22, 2018Liu JJ, Sharma K, Zangrandi L, Chen C, Humphrey SJ, Chiu YT, Spetea M, Liu-Chen LY, Schwarzer C, Mann M.

(11) Development of functionally selective, small molecule agonists at kappa opioid receptorsThe Journal of biological chemistryDecember 20, 2013Zhou L, Lovell KM, Frankowski KJ, Slauson SR, Phillips AM, Streicher JM, Stahl E, Schmid CL, Hodder P, Madoux F, et al.

(13) High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell deathProceedings of the National Academy of Sciences of the United States of AmericaApril 3, 2012Fox JT, Sakamuru S, Huang R, Teneva N, Simmons SO, Xia M, Tice RR, Austin CP, Myung K.

(14) GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal ratsPloS oneJanuary 1, 2012Grachev P, Li XF, Lin YS, Hu MH, Elsamani L, Paterson SJ, Millar RP, Lightman SL, O'Byrne KT.

(15) Medial dorsal hypothalamus mediates the inhibition of reward seeking after extinctionThe Journal of neuroscience : the official journal of the Society for NeuroscienceOctober 20, 2010Marchant NJ, Furlong TM, McNally GP.

(+/-)-U-50488 hydrochloride