DL-AP5 from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemDL-AP5
CompanyTocris Bioscience, a Bio-Techne Brand
Price $109.00Supplier Page View Company Product Page
Catalog Number0105/10
Quantity10 mg (also 50 mg)
Purity98%
Molecular Weight197.13
Molecule NameDL-2-Amino-5-phosphonopentanoic acid
FormulaC5H12NO5P
StorageStore at RT

Specifications/Features

Sizes Available: 10 mg (also 50 mg)

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Complex opioid-driven modulation of glutamatergic and cholinergic neurotransmission in a GABAergic brain nucleus associated with emotion, reward, and addictioneLifeDecember 1, 2025Ramesh Chittajallu, Anna Vlachos, Adam P Caccavano, Xiaoqing Yuan, Steven Hunt, Daniel Abebe, Edra London, Kenneth A Pelkey, Chris J McBainpooled. Reagents Pharmacological reagents used in this study are as follows: DNQX (Cat. No. 2312/10), DL-APV (Cat. No. 0105/10), CGP55845A (Cat. No. 1248/10), Picrotoxin (Cat. No. 1128), bicuculline (Cat. No. 0109/10), DAMGO (Cat.

(2) Rebound bursting selectively enables fast dynamics in dopamine midbrain neurons projecting to the dorso-lateral striatumJ NeurosciOctober 29, 2025Strahinja Stojanovic, Christopher J. Knowlton, Richard Egger-Mackrodt, Johanna Mankel, Josef Shin, Stephan Lammel, Carmen C. Canavier, Jochen Roeper,Tocris Bioscience,Catalog #1248/10 CNQX,20 µm,Tocris Bioscience,Catalog #1045/1 DL-AP5,10 µm,Tocris Bioscience,Catalog #0105/10 Isradipine,300 nm,Tocris Bioscience,Catalog #2004/10 Ivabradine,25 µm,Tocris Bioscience,Catalog #6542 NNC

(3) Activity-dependent development of synaptic circuits mediates direction selectivity in an axis-specific mannerCell ReportsJuly 22, 2025Karina Bistrong, Rachana Deven Somaiya, Eugene Y. Liang, Benjamin E. Smith, Marla B. FellerMedia,Sigma,Cat# A1420-10X1L Hexamethonium Bromide,Sigma,Cat# 501806478 DL-AP5,Tocris Biosciences,Cat# 010510 DNQX,Tocris Biosciences,Cat# 018910 Tetrodotoxin citrate,Tocris Biosciences,Cat# 1069 Alexa Fluor 594 Hydrazide

(4) Protocol to study projection-specific circuits in the basal ganglia of adult mice using viral vector tracing, optogenetics, and patch-clamp techniqueSTAR ProtocolsSeptember 2, 2023Ya-Wei Ji, Xiang-Ying Xu, Cui Yin, Chunyi Zhou, Cheng XiaoCAS: 479347-85-8 DL-2-amino-5-phosphonopentanoic acid (APV),"Tocris, Park Ellisville, MO, USA",Cat# 0105/10 CAS: 76326-31-3 Sodium pentobarbital,"Sigma-Aldrich, St. Louis, MO, USA",Cat# P3761 CAS: 57-33-0 Ophthalmic

(5) Multi-target action of β-alanine protects cerebellar tissue from ischemic damageCell death & diseaseAugust 29, 2022Kopach O, Rusakov DA, Sylantyev S.

(6) Negative Allosteric Modulation of Gamma-Aminobutyric Acid A Receptors at α5 Subunit–Containing Benzodiazepine Sites Reverses Stress-Induced Anhedonia and Weakened Synaptic Function in MiceBiological PsychiatryAugust 1, 2022Timothy A. Troppoli, Panos Zanos, Polymnia Georgiou, Todd D. Gould, Uwe Rudolph, Scott M. Thompsonor Drug,DNQX,Sigma-Aldrich,Cat. No. D0540, Chemical Compound or Drug,APV,Tocris Bioscience,Cat. No. 0105/10, Chemical Compound or Drug,ketamine,Sigma-Aldrich,Cat. No. K2753, Organism/Strain,alpha5 knock-out

(7) The Amygdala Noradrenergic System Is Compromised With Alcohol Use DisorderBiological PsychiatryJune 1, 2022Florence P. Varodayan, Reesha R. Patel, Alessandra Matzeu, Sarah A. Wolfe, Dallece E. Curley, Sophia Khom, Pauravi J. Gandhi, Larry Rodriguez, Michal Bajo, Shannon D’Ambrosio, et al.Drug,propranolol hydrochloride,Tocris,Cat. No. 0624/100, Chemical Compound or Drug,DL-AP-5,Tocris,Cat. No. 0105/10, Chemical Compound or Drug,CGP 55845A,Tocris,Cat. No. 1248/10, Chemical Compound or Drug,DNQX,Tocris,Cat.

(8) Relaxation of synaptic inhibitory events as a compensatory mechanism in fetal SOD spinal motor networkseLifeDecember 23, 2019Pascal Branchereau, Elodie Martin, Anne-Emilie Allain, William Cazenave, Laura Supiot, Fara Hodeib, Amandine Laupénie, Urvashi Dalvi, Hongmei Zhu, Daniel CattaertµM "Chemical compound, drug",(2R)-amino-5-phosphonovaleric acid (DL-AP5),"Bio-techne, France",Cat#0105/10,40 µM "Chemical compound, drug","6-cyano-7-nitroquinoxaline-2,3-dione (CNQX)","Bio-techne, France",Cat#0190/10,20

(9) TMEM16B regulates anxiety-related behavior and GABAergic neuronal signaling in the central lateral amygdalaeLifeSeptember 4, 2019Li KX, He M, Ye W, Simms J, Gill M, Xiang X, Jan YN, Jan LY.https://biorender.com/. Reagents Pharmacological drugs used included 100 μM Picrotoxin (Tocris, Cat. No. 1128/1G), 50 µM DL-AP5 (Tocris, Cat. No. 0105/10), 20 µM DNQX (Tocris, Cat. No. 2312/10), Tetrodotoxin (abcam, ab120054), QX-314 (Tocris, Cat. No. 1014/100),

(10) Lmx1b is required at multiple stages to build expansive serotonergic axon architectureseLifeJuly 29, 2019Donovan LJ, Spencer WC, Kitt MM, Eastman BA, Lobur KJ, Jiao K, Silver J, Deneris ES.

(11) Endocannabinoid Signaling Mediates Local Dendritic Coordination between Excitatory and Inhibitory SynapsesCell reportsApril 16, 2019Hu HY, Kruijssen DLH, Frias CP, Rózsa B, Hoogenraad CC, Wierenga CJ.

(12) Prenatal selective serotonin reuptake inhibitor (SSRI) exposure induces working memory and social recognition deficits by disrupting inhibitory synaptic networks in male miceMolecular brainApril 1, 2019Yu W, Yen YC, Lee YH, Tan S, Xiao Y, Lokman H, Ting AKT, Ganegala H, Kwon T, Ho WK, et al.

(13) Somatostatin Interneurons Promote Neuronal Synchrony in the Neonatal HippocampusCell reportsMarch 19, 2019Flossmann T, Kaas T, Rahmati V, Kiebel SJ, Witte OW, Holthoff K, Kirmse K.

(14) Differential Regulation of Syngap1 Translation by FMRP Modulates eEF2 Mediated Response on NMDAR ActivityFrontiers in molecular neuroscienceJanuary 1, 2019Paul A, Nawalpuri B, Shah D, Sateesh S, Muddashetty RS, Clement JP.

(15) Differences in glutamate uptake between cortical regions impact neuronal NMDA receptor activationCommunications biologyJanuary 1, 2019Romanos J, Benke D, Saab AS, Zeilhofer HU, Santello M.

(16) AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca²⁺-Permeable AMPA Receptors to Control LTPCell reportsOctober 23, 2018Purkey AM, Woolfrey KM, Crosby KC, Stich DG, Chick WS, Aoto J, Dell'Acqua ML.

(17) Pathway-Specific Alterations of Cortico-Amygdala Transmission in an Arthritis Pain ModelACS chemical neuroscienceSeptember 19, 2018Kiritoshi T, Neugebauer V.

(18) Cerebrospinal Fluid-Contacting Neurons Sense pH Changes and Motion in the HypothalamusThe Journal of neuroscience : the official journal of the Society for NeuroscienceAugust 29, 2018Jalalvand E, Robertson B, Tostivint H, Löw P, Wallén P, Grillner S.

(19) Triheteromeric GluN1/GluN2A/GluN2C NMDARs with Unique Single-Channel Properties Are the Dominant Receptor Population in Cerebellar Granule CellsNeuronJuly 1, 2018Subhrajit Bhattacharya, Alpa Khatri, Sharon A. Swanger, John O. DiRaddo, Feng Yi, Kasper B. Hansen, Hongjie Yuan, Stephen F. Trayneliscompetitive antagonist D,L-2-amino-5-phosphonovalerate (DL-APV, 200 μM, Tocris, Bristol, UK, Cat. No. 0105/10) was applied to confirm that the currents measured in response to pressure application of NMDA and glycine

(20) Design and validation of a foldable and photovoltaic wide-field epiretinal prosthesisNature communicationsMarch 8, 2018Ferlauto L, Airaghi Leccardi MJI, Chenais NAL, Gilliéron SCA, Vagni P, Bevilacqua M, Wolfensberger TJ, Sivula K, Ghezzi D.

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DL-AP5

DL-AP5

DL-AP5 from Tocris Bioscience, a Bio-Techne Brand

Description

Specifications/Features

Tocris Bioscience, a Bio-Techne Brand

Citations (106)

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DL-AP5 from Tocris Bioscience, a Bio-Techne Brand

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