TCS OX2 29 from Tocris Bioscience, a Bio-Techne Brand | Biocompare.com

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TCS OX2 29

Potent and selective OX2 antagonist

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Tocris Bioscience, a Bio-Techne Brand for
TCS OX2 29

Description

Potent and selective OX2 antagonist

Product Specs
ItemTCS OX2 29
CompanyTocris Bioscience, a Bio-Techne Brand
Price $294.00Supplier Page View Company Product Page
Catalog Number3371/10
Purity98%
Molecular Weight433.97
Molecule Name(2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanone hydrochloride
FormulaC23H31N3O3.HCl
StorageDesiccate at +4°C
Quantity10 mg (also 50 mg)

Specifications/Features

Sizes Available: 10 mg (also 50 mg)

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Orexin-B exerts excitatory effects on nigral dopaminergic neurons and alleviates motor disorders in MPTP parkinsonian miceNeuroscience lettersNovember 20, 2021Bian K, Liu C, Wang Y, Xue Y, Chen L.

(2) The effect of intracerebroventricular administration of orexin receptor type 2 antagonist on pentylenetetrazol-induced kindled seizures and anxiety in ratsBMC neuroscienceAugust 13, 2018Asadi S, Roohbakhsh A, Shamsizadeh A, Fereidoni M, Kordijaz E, Moghimi A.

(3) Upregulation of orexin receptor in paraventricular nucleus promotes sympathetic outflow in obese Zucker ratsNeuropharmacologyDecember 1, 2015Zhou JJ, Yuan F, Zhang Y, Li DP.

(4) Both Ox1R and Ox2R orexin receptors contribute to the cardiorespiratory response evoked from the perifornical hypothalamusClinical and experimental pharmacology & physiologyOctober 1, 2015Beig MI, Horiuchi J, Dampney RA, Carrive P.

(5) Orexin-A promotes cell migration in cultured rat astrocytes via Ca2+-dependent PKCα and ERK1/2 signalsPloS oneJanuary 1, 2014Shu Q, Hu ZL, Huang C, Yu XW, Fan H, Yang JW, Fang P, Ni L, Chen JG, Wang F.

(6) Central orexin (hypocretin) 2 receptor antagonism reduces ethanol self-administration, but not cue-conditioned ethanol-seeking, in ethanol-preferring ratsThe international journal of neuropsychopharmacologyOctober 1, 2013Brown RM, Khoo SY, Lawrence AJ.

(7) A role for hypocretin/orexin receptor-1 in cue-induced reinstatement of nicotine-seeking behaviorNeuropsychopharmacology : official publication of the American College of NeuropsychopharmacologyAugust 1, 2013Plaza-Zabala A, Flores Á, Martín-García E, Saravia R, Maldonado R, Berrendero F.

(8) Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activationThe Journal of biological chemistryApril 27, 2012Xu TR, Ward RJ, Pediani JD, Milligan G.

(9) Orexins/hypocretins acting at Gi protein-coupled OX 2 receptors inhibit cyclic AMP synthesis in the primary neuronal culturesJournal of molecular neuroscience : MNJanuary 1, 2012Urbańska A, Sokołowska P, Woldan-Tambor A, Biegańska K, Brix B, Jöhren O, Namiecińska M, Zawilska JB.

(10) Orexins depolarize rostral ventrolateral medulla neurons and increase arterial pressure and heart rate in rats mainly via orexin 2 receptorsThe Journal of pharmacology and experimental therapeuticsAugust 1, 2010Huang SC, Dai YW, Lee YH, Chiou LC, Hwang LL.

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