Thapsigargin from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemThapsigargin
CompanyTocris Bioscience, a Bio-Techne Brand
Price $139.00Supplier Page View Company Product Page
Catalog Number1138/1
Quantity1 mg
Purity97%
Molecular Weight650.76
Molecule Name(3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate
FormulaC34H50O12
StorageStore at -20°C

Specifications/Features

Sizes Available: 1 mg

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Genetic knock-in of EIF2AK3 variants reveals differences in PERK activity in mouse liver and pancreas under endoplasmic reticulum stressScientific ReportsOctober 11, 2024Shivesh Ghura, Noah R. Beratan, Xinglong Shi, Elena Alvarez-Periel, Sarah E. Bond Newton, Cagla Akay-Espinoza, Kelly L. Jordan-Sciuttofactor (M-CSF; catalog #416-ML-500) was from R&D Systems (Minneapolis, MN), thapsigargin (catalog #11381) was from Tocris (Bristol, UK), the PERK activator CCT020312 (catalog #324879) was from Millipore Sigma

(2) Betaine promotes osteogenic differentiation in immortalized human dental pulp-derived cellsBDJ OpenOctober 7, 2022Chatvadee Kornsuthisopon, Dusit Nantanapiboon, Sunisa Rochanavibhata, Nunthawan Nowwarote, Worachat Namangkalakul, Thanaphum Osathanoninvestigate the influence of BET on calcium influx, cells were pretreated with 10 µM thapsigargin (Cat. no. 1138/1, R&D Systems, USA) or 50 µM TMB-8 (Cat. no. 53464725, Sigma-Aldrich, USA) before being stimulated with

(3) Quantal Ca(2+) release mediated by very few IP(3) receptors that rapidly inactivate allows graded responses to IP(3)Cell reportsNovember 2, 2021Rossi AM, Riley AM, Dupont G, Rahman T, Potter BVL, Taylor CW.USA)",Cat#GE17-0510-01 Saponin,Sigma-Aldrich,Cat#S4521 Thapsigargin,"Bio-Techne (Middlesex, UK)",Cat#1138/1 Triethylamine,Sigma-Aldrich,Cat#90340 ,, Critical commercial assays,Critical commercial assays,Critical

(4) Autocrine regulation of wound healing by ATP release and P2Y₂ receptor activationLife sciencesOctober 15, 2021McEwan TB, Sophocleous RA, Cuthbertson P, Mansfield KJ, Sanderson-Smith ML, Sluyter R.

(5) Ca²⁺ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the murine coloneLifeJanuary 5, 2021Baker SA, Leigh WA, Del Valle G, De Yturriaga IF, Ward SM, Cobine CA, Drumm BT, Sanders KM.E4378 Chemical compound, drug Thapsigargin, isradipine, Z-944, CPA, ryanodine Tocris Bioscience Cat# 1138/1; Cat# 2004/10; Cat# 6367/10; Cat# 1235/10; Cat# 1329/1 Chemical compound, drug GSK 7975A Aobious Cat#

(6) Cannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblastsCell death & diseaseSeptember 1, 2020Lowin T, Tingting R, Zurmahr J, Classen T, Schneider M, Pongratz G.µM 68,69 Capsazepine GPN 464 14634 Tocris Cayman DMSO DMSO 10 µM 250 µM 29,70 Thapsigargin Decynium-22 1138/1 4722 Tocris Tocris DMSO DMSO 10 µM 10 µM 72 7,8,23 30,65 22,66,67 Acknowledgements We thank

(7) Calcium-stimulated disassembly of focal adhesions mediated by an ORP3/IQSec1 complexeLifeApril 1, 2020D'Souza RS, Lim JY, Turgut A, Servage K, Zhang J, Orth K, Sosale NG, Lazzara MJ, Allegood J, Casanova JE.(Rockford, Il)",(A22287),Dilution of 1:1000 "Chemical compound, drug",Thapsigargin,"Tocris (Bristol, UK)",(1138),1 µM "Chemical compound, drug",Phorbol 12-myristate 13-acetate (PMA),"Tocris (Bristol, UK)",(1201/1),2.5

(8) Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stresseLifeAugust 27, 2019Shemorry A, Harnoss JM, Guttman O, Marsters SA, Kőműves LG, Lawrence DA, Ashkenazi A.

(9) GPN does not release lysosomal Ca²⁺ but evokes Ca²⁺ release from the ER by increasing the cytosolic pH independently of cathepsin CJournal of cell scienceFebruary 1, 2019Atakpa P, van Marrewijk LM, Apta-Smith M, Chakraborty S, Taylor CW.

(10) Calcium oscillations coordinate feather mesenchymal cell movement by SHH dependent modulation of gap junction networksNature communicationsDecember 18, 2018Li A, Cho JH, Reid B, Tseng CC, He L, Tan P, Yeh CY, Wu P, Li Y, Widelitz RB, et al.

(11) IP₃ Receptors Preferentially Associate with ER-Lysosome Contact Sites and Selectively Deliver Ca²⁺ to LysosomesCell reportsDecember 11, 2018Atakpa P, Thillaiappan NB, Mataragka S, Prole DL, Taylor CW.

(12) Mitochondria-Derived Vesicles Deliver Antimicrobial Reactive Oxygen Species to Control Phagosome-Localized Staphylococcus aureusCell host & microbeNovember 14, 2018Abuaita BH, Schultz TL, O'Riordan MX.

(13) Increased sensitivity to apoptosis upon endoplasmic reticulum stress-induced activation of the unfolded protein response in chemotherapy-resistant malignant pleural mesotheliomaBritish journal of cancerJuly 1, 2018Xu D, Liang SQ, Yang H, Lüthi U, Riether C, Berezowska S, Marti TM, Hall SRR, Bruggmann R, Kocher GJ, et al.

(14) Mechanical regulation of stem-cell differentiation by the stretch-activated Piezo channelNatureMarch 1, 2018He L, Si G, Huang J, Samuel ADT, Perrimon N.

(15) Hyperactivation of nuclear receptor coactivators induces PERK-dependent cell deathOncotargetFebruary 20, 2018Hossain MM, Barua D, Arabkari V, Islam N, Gupta A, Gupta S.

(16) Dysfunctional autophagy following exposure to pro-inflammatory cytokines contributes to pancreatic β-cell apoptosisCell death & diseaseJanuary 24, 2018Lambelet M, Terra LF, Fukaya M, Meyerovich K, Labriola L, Cardozo AK, Allagnat F.

(17) The Endocannabinoid Metabolite Prostaglandin E₂ (PGE₂)-Glycerol Inhibits Human Neutrophil Functions: Involvement of Its Hydrolysis into PGE₂ and EP ReceptorsJournal of immunology (Baltimore, Md. : 1950)April 15, 2017Turcotte C, Zarini S, Jean S, Martin C, Murphy RC, Marsolais D, Laviolette M, Blanchet MR, Flamand N.

(18) Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastomaOncotargetApril 4, 2017Florea AM, Varghese E, McCallum JE, Mahgoub S, Helmy I, Varghese S, Gopinath N, Sass S, Theis FJ, Reifenberger G, et al.

(19) NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2α-ATF4 signalling in breast cancerOncogeneNovember 10, 2016Gupta A, Hossain MM, Miller N, Kerin M, Callagy G, Gupta S.

(20) Control of sensory neuron excitability by serotonin involves 5HT2C receptors and Ca(2+)-activated chloride channelsNeuropharmacologyNovember 1, 2016Salzer I, Gantumur E, Yousuf A, Boehm S.