A 83-01 from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemA 83-01
CompanyTocris Bioscience, a Bio-Techne Brand
Price $308.00Supplier Page View Company Product Page
Catalog Number2939/10
Quantity10 mg (also 50 mg)
Purity98%
Molecular Weight421.52
Molecule Name3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
FormulaC25H19N5S
StorageStore at -20°C

Specifications/Features

Sizes Available: 10 mg (also 50 mg)

Add to Compare List

Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Tumor-targeted bispecific antibodies effectively inhibit oncogenic pathways while minimizing toxicitySci AdvMay 22, 2026Yvonne T. Kschonsak, Wei-Ching Liang, Joyce Chan, David Kan, Thao Nguyen, Karen Ruiz, Yee-Seir Kee, Wen-Ting K. Tsai, Hongkang Xi, Marina Moskalenko, et al.EGF (50 ng/ml; R&D Systems, 236-RG), Noggin (100 ng/ml; R&D Systems, 6057-NG), 500 nM A83-01 (Tocris, 2939), 10 nM Gastrin (Tocris, 3006), R-Spondin 3 (250 ng/ml; Genentech), and Wnt3A conditioned media. Organoid

(2) Patient-derived organoids guide personalized therapy for KRAS-mutant pancreatic cancer: synergistic MEK/mTOR inhibition and predictive chemotherapy responsesFront ImmunolMay 15, 2026Xiaorui Wang, Lijuan Liu, Feng Li, Yanyan Da, Fang Hu, Xin Qi, Yiwen Pan, Meng Jiang, Peng Hou, Jin Yang,Sino Biological,10573-HNAE Prostaglandin E2,Tocris,2296-10mg RHOK inhibitor Y-27632,Abmole Bioscience,M1817 A-83-01,Tocris,2939/10 Forskolin,Tocris,1099 Collagenase,Sigma,C9407 Dispase II,Solarbio,D6430 DNase I,Roche,11284932001 Collagenase

(3) Early fibrotic niches establish tumour-permissive microenvironmentsNatureApril 22, 2026Erik C. Cardoso, Hyeyoung Lee, Frances J. England, Hyunjin Cho, Robin Lu, Sagar S. Varankar, Moo Suk Park, Natasha Rekhtman, Bon-Kyoung Koo, Benjamin D. Simons, et al.ng ml−1 of human NOGGIN (PeproTech; 120-10 C), 3 μM CHIR99021 (Tocris; 4423), 500 nM A83-01 (Tocris; 2939), 10 μM SB431542 (Tocris; 616461), 1× penicillin–streptomycin, 500 μg ml−1 of Primocin (InvivoGen; ant-pm-1)

(4) Small molecule-directed differentiation of submerged-cultured human nasal airway epithelia for respiratory disease modelingCell Reports MedicineApril 21, 2026Henriette H.M. Dreyer, Georgia-Nefeli Ithakisiou, Sacha Spelier, Malina K. Iwanski, Eugene Katrukha, Jonne Terstappen, Lisa W. Rodenburg, Aditi Shekhar, Loes A. den Hertog-Oosterhoff, Shannon M.A. Smits, et al.,Thermo Fisher Scientific,Cat#15290018 Gentamicin,Sigma-Aldrich,Cat#G1397 Vancomycin,Sigma-Aldrich,Cat#SBR00001 A83-01,Tocris,Cat#2939/10 Y-27632,Selleck Chemicals,Cat#S1049 Rapamycin,Sigma-Aldrich,Cat#553210 DAPT,Thermo Fisher Scientific,Cat#15467109 DMH1,Selleck Chemicals

(5) Protocol for lentiviral engineering and multi-omic characterization of human kidney tubuloidsSTAR ProtocolsMarch 20, 2026Giulia Perticari, Maroussia M.P. Ganpat, Jarno Drost,Abmole Bioscience,Cat# M1817 EGF,PeproTech,Cat# AF-100-15 FGF10,PeproTech,Cat# 100-26 A83-01,Tocris,Cat# 2939/10 Next Generation Surrogate (NGS) Wnt,ImmunoPrecise Antibodies,Cat# N001 - 100 mg BME,Trevigen,Cat#

(6) WNT7B drives a program for pancreatic cancer subtype switching and progressioniScienceMarch 20, 2026Joep Sprangers, Jeroen M. Bugter, Despina Xanthakis, Michiel Boekhout, Rutger N.U. Kok, Veerle E. Geurts, Hans Clevers, Lodewijk A.A. Brosens, Frederike Dijk, Maria J. Rodríguez Colman, et al.,Cayman Chemicals,14072 N-acetylcysteine,Sigma-Aldrich,A9165 Nicotinamide,Sigma-Aldrich,N0636 Y-27632 (ROCK inhibitor),Selleckchem,S1049 A83-01 (TGFβ / ALK5 inhibitor),Tocris,2939/10 Polybrene (hexadimethrine bromide),Merck,3701-03-3 Puromycin,Santa Cruz,SC-108071 Matrigel,Corning,356231 Basement Membrane

(7) HAND1 controls the lineage bifurcation of trophoblast and amnion from human pluripotent stem cellsCell Mol Life SciMarch 10, 2026Changmiao Pang, Qifeng Yang, Yulong Zhong, Jinhao Ye, Yufang Lv, Shufei Xie, Yanqing Tang, Xianhua Ye, Feifan Zhang, Chao Li, et al.(Sigma, 49752-100G), 2 μM CHIR99021 (TOCRIS, 4423), 1 μM SB431542 (Sigma, 616461), 0.5 μM A83-01(TOCRIS, 2939), 10 μM valproic acid sodium salt (APExBIO, Valproic acid), 50 ng/ml EGF (R&D, 236-EG-200), 5 μM Y-27632

(8) Oncolytic virotherapy potentiates chemo-PD-1 immunotherapy by engaging chemo-resistant bystander CD8+ T cellsJ Immunother CancerMarch 4, 2026Yang Yang, Junjian He, Texi Liang, Kaiyi Li, Yao Lin, Hairu Wang, Wenwen Xi, Shusen Ye, Ding Qiu, Chunyang Xie, et al.recombinant human Noggin (Gibco, 120–10C), 10 µM forskolin (Selleckchem, S2449), 5 µM A83-01 (TOCRIS, 2939), 10 µM Y27632 (Selleckchem, S1049), 3 µM SB202190 (Selleckchem, S1077), 3 nM dexamethasone (Selleckchem,

(9) Intestinal epithelial TLR5 signaling promotes barrier-supportive macrophagesScience ImmunologyJanuary 23, 2026Ming-Ting Tsai, Ryann Callaghan, Charles Ng, Lisette Peres-Tintin, Dean B. Matthews, Nikketa Stanford, Karuna Ganesh, Mary K. Estes, Gretchen E. Diehl(Sigma-Aldrich, #N0630), 10 nM human [Leu15]Gastrin-I (Sigma-Aldrich #G9145), 500 nM A-83-01 (Tocris Bioscience, #2939), 10 μM SB202190 (Sigma-Aldrich, #S7067), 1x B27 supplement (Gibco, #17504044), 1x N2 supplement (Gibco,

(10) Gene expression profiling reveals enhanced nutrient and drug metabolism and maturation of hiPSC-derived intestine-on-chip relative to organoids and TranswellsStem cell reportsDecember 9, 2025Moerkens R, Mooiweer J, Smits E, Berg M, Ramírez-Sánchez AD, Modderman R, Puschhof J, Pleguezuelos-Manzano C, Barrett RJ, Wijmenga C, et al.(1x, Thermo Fisher Scientific #17504044), SB202190 (10 μM, Tocris #1264/10), A83-01 (500 nM, Tocris #2939/10), hereafter named “expansion medium” (EM), and Y-27632 (10 μM, Tocris #1254/10). After 48 h, the medium

(11) NovumRNA: Accurate prediction of non-canonical tumor antigens from RNA sequencing dataiScienceOctober 17, 2025Markus Ausserhofer, Dietmar Rieder, Manuel Facciolla, Raphael Gronauer, Giorgia Lamberti, Rebecca Lisandrelli, Serena Pellegatta, Zlatko Trajanoski, Francesca Finotello(Thermo Scientific, Cat#17504044), 1.25 mM N-Acetylcysteine (Sigma, Cat#A9165), 0.5 nM A83-01 (Tocris, Cat#2939), 10 mM SB202190 (Sigma, Cat#S7067), 50 ng/mL human EGF (Peprotech, Cat#AF-100-15), 100 mg/mL Primocin (Invivogen,

(12) Multi-layer stratified oncology platform utilizing transcriptomics, prostate cancer organoids, and modeling of drug responseJ Exp Clin Cancer ResOctober 16, 2025Juening Kang, Panagiotis Chouvardas, Andrew Maalouf, Daniel Hanhart, Laura Fernández Cerro, Wanli Cheng, Eva Compérat, Katja Ovchinnikova, Rahel Etter, Michaela Medová, et al.10 µM SB202190 (Selleckchem, S1077), 100 ng/ml Noggin (Peprotech, 250 − 38), 500 nM A83-01 (Tocris, 2939), 10 nM DHT (Fluka Chemica, 10300), 10 ng/ml Wnt3a (Peprotech, 315 − 20), 50 ng/ml HGF (Peprotech, 100 − 39

(13) Human colon stem cells are the predominant epithelial responders to bacterial antigensFront ImmunolOctober 15, 2025Maaike H. De Vries, Claartje A. Meddens, Hemme J. Hijma, Anne-Claire Berrens, Suze A. Jansen, Berend A. P. Kooiman, Scott Snapper, Hans Clevers, Michal Mokry, Ewart W. Kuijk, et al.(Gibco, 12634028) containing RSPO1, noggin, EGF (Peprotech, 315-09-1MG), A83-01 (Tocris Bioscience, 2939/10), nicotinamide (SIGMA-ALDRICH, N0636-500G), SB202190 (SIGMA-ALDRICH, S7067-25mg), and WNT3A. To induce

(14) A Practical Guide to Developing and Troubleshooting Patient-Derived "Mini-Gut" Colorectal Organoids for Clinical ResearchMethods ProtocOctober 11, 2025Rex Devasahayam Arokia Balaya, Zahra Heydari, Gobinda Sarkar, Estela Mariel Cruz Garcia, Jose M. de Hoyos-Vega, Eugene Krueger, Lauren Helgeson, Alexander Revzin, Alexandra Ros, Akhilesh Pandey, et al.colon stem cell compartments." A83-01,500 μM,50 μL,500 nM,"Tocris Bioscience (Minneapolis, MN, USA)",293910,ALK4/5/7 (TGF-β) inhibitor; inhibits the premature differentiation of colon epithelium and supports

(15) Auranofin Synergizes with Cisplatin in Reducing Tumor Burden of NOTCH-Dependent Ovarian CancerCancer Res CommunOctober 1, 2025Robert J. Lake, Parisa Nikeghbal, Irina V. Lagutina, Kimberly K. Leslie, Mara P. Steinkamp, Hua-Ying Fanß-estradiol (Sigma, E2758), 2% Primocin, 5 mmol/L nicotinamide (Sigma, N0636), 5 μmol/L A83-01 (Tocris, 2939), 10 μmol/L Y-27632 (Sigma, Y0503),10 μmol/L forskolin (Tocris, 1099), and 250 μg/mL hydrocortisone (Sigma,

(16) Auranofin synergizes with cisplatin in reducing tumor burden of Notch-dependent ovarian cancerCancer Research CommunicationsOctober 1, 2025Robert J. Lake, Parisa Nikeghbal, Irina V. Lagutina, Kimberly K. Leslie, Mara P. Steinkamp, Hua-Ying Fanß-estradiol (Sigma, E2758), 2% Primocin, 5 mmol/L nicotinamide (Sigma, N0636), 5 μmol/L A83-01 (Tocris, 2939), 10 μmol/L Y-27632 (Sigma, Y0503),10 μmol/L forskolin (Tocris, 1099), and 250 μg/mL hydrocortisone (Sigma,

(17) Organoid models established from primary tumors and patient-derived xenograft tumors reflect platinum sensitivity of ovarian cancer patientsBMC cancerSeptember 30, 2025Nikeghbal P, Zamanian D, Burke D, Steinkamp MP.nM ß-estradiol (Sigma, E2758), 2% primocin, 5 mM nicotinamide (Sigma, N0636), 5 µM A83-01 (Tocris, 2939), 10 µM Y-27632 (Sigma, Y0503),10 µM forskolin (Tocris, 1099), and 250 µg/ml hydrocortisone (Sigma, H0888).

(18) Refined and benchmarked homemade media for cost-effective, weekend-free human pluripotent stem cell cultureOpen Research EuropeSeptember 19, 2025Lukasz Truszkowski, Sveva Bottini, Sara Bianchi, Mirko G. Scrivano, Giulia Ferrari Ramondo, Linda Belluci, Helen Bell, Silvia Becca, Kirsten E Snijders, Giulia Savorè, et al.ng µL -1 EGF (PeproTech, #AF-100-15), 10 nM Gastrin (Sigma-Aldrich, #G9145), 500 nM A83-01 (Tocris, #2939), 10 µM SB202190 (Sigma-Aldrich, #S7067-5MG), 3 µM CHIR99021, 50% Wnt3a-conditioned medium, 500 ng µL -1

(19) Maternal Western diet increases inflammatory markers and decreases barrier function of offspring in Papio anubisAmerican Journal of Physiology-Gastrointestinal and Liver PhysiologyAugust 1, 2025Grant H. Gershner, Alena Golubkova, Cody Dalton, Camille Schlegel, Chase Calkins, Darlene N. Reuter, Megan Learner, James F. Papin, Sunam Gurung, Karen R. Jonscher, et al.MA), 1 mM N-acetylcysteine (Millipore Sigma, #A9165–5G, Burlington, MA), 500 nM A-83–01 (R&D Systems, #2939/10, Minneapolis, MN), 10 μM SB202190 (Millipore Sigma, #S7067–5 MG, Burlington, MA), 10 mM nicotinamide

(20) The Role of GPX Enzymes, Lipid Profiles, and Iron Accumulation in Necrotizing EnterocolitisInternational journal of molecular sciencesJune 25, 2025Gershner GH, Calkins C, Golubkova A, Schlegel C, Massahi A, Lerner M, Frickenstein AN, Bonvicino S, Agbaga MP, Hunter CJ.mM N-Acetylcysteine (Millipore Sigma, #A9165-5G, Burlington, MA, USA), 500 nM A-83-01 (R&D Systems, #2939/10, Minneapolis, MN, USA), 10 µM SB202190 (Millipore Sigma, #S7067-5 MG, Burlington, MA, USA), 10 mM Nicotinamide

Be the First to Write a Review!

A 83-01

A 83-01 from Tocris Bioscience, a Bio-Techne Brand

Description

Specifications/Features

Tocris Bioscience, a Bio-Techne Brand

Citations (185)

Reviews

A 83-01 from Tocris Bioscience, a Bio-Techne Brand

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map