(+)-Bicuculline from Tocris Bioscience, a Bio-Techne Brand

Product Specs
Item(+)-Bicuculline
CompanyTocris Bioscience, a Bio-Techne Brand
Price $295.00Supplier Page View Company Product Page
Catalog Number0130/50
Quantity50 mg
Purity98%
Molecular Weight367.36
Molecule Name[R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one
FormulaC20H17NO6
StorageStore at +4°C

Specifications/Features

Sizes Available: 50 mg

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Impaired synaptic plasticity in an animal model of autism exhibiting early hippocampal GABAergic-BDNF/TrkB signaling alterationsiScienceJanuary 20, 2023Martina Sgritta, Beatrice Vignoli, Domenico Pimpinella, Marilena Griguoli, Spartaco Santi, Andrzej Bialowas, Grzegorz Wiera, Paola Zacchi, Francesca Malerba, Cristina Marchetti, et al.(L-AP4),Tocris,Cat#0103/1 "(2S,2′R,3′R)-2-(2′,3′-dicarboxycyclopropyl) glycine (DCG-IV)",Tocris,Cat#0975 Bicuculline,Tocris,Cat#0130/50 Picrotoxin,Tocris,Cat#1128 Gramicidin,SIGMA,Cat#G5002 Alexa Fluo 488,Life Technologies,Cat#A10436 BDNF,SIGMA,SRP3014 K252a,Merck

(2) Axonal transport of Hrs is activity dependent and facilitates synaptic vesicle protein degradationLife science allianceOctober 1, 2022Birdsall V, Kirwan K, Zhu M, Imoto Y, Wilson SM, Watanabe S, Waites CL.transduced at six DIV, and experiments performed at 14–15 DIV. To induce activity, 40 μM bicuculline (Bic, #0130/50; Tocris) and 50 μM 4-aminopyridine (4AP, #940; Tocris) were added to the culture media at 37°C. After

(3) MDGAs are fast-diffusing molecules that delay excitatory synapse development by altering neuroligin behavioreLifeMay 9, 2022Toledo A, Letellier M, Bimbi G, Tessier B, Daburon S, Favereaux A, Chamma I, Vennekens K, Vanderlinden J, Sainlos M, et al.16G020 Passage + 6,RRID:CVCL_0063,MDGA1 peptide production "Chemical compound, drug",Bicuculine,TOCRIS #0130/50,RRID:SCR_003689,Block inhibitory synaptic transmission "Chemical compound, drug",Phosphocreatine,Calcbiochem#2380–5

(4) Nucleus Accumbens Tac1-Expressing Neurons Mediate Stress-Induced Anhedonia-like Behavior in MiceCell reportsNovember 3, 2020He ZX, Yin YY, Xi K, Xing ZK, Cao JB, Liu TY, Liu L, He XX, Yu HL, Zhu XJ.

(5) Optogenetic control of excitatory post-synaptic differentiation through neuroligin-1 tyrosine phosphorylationeLifeApril 23, 2020Letellier M, Lagardère M, Tessier B, Janovjak H, Thoumine O.drug D-AP5 TOCRIS (RRID:SCR_003689) 0106/10 50 mM Chemical compound, drug Bicuculline TOCRIS (RRID:SCR_003689) 0130/50 20 mM Chemical compound, drug NBQX TOCRIS (RRID:SCR_003689) 0373/10 100 nM or 10 mM Chemical compound,

(6) Myosin VI Drives Clathrin-Mediated AMPA Receptor Endocytosis to Facilitate Cerebellar Long-Term DepressionCell reportsJuly 2, 2019Wagner W, Lippmann K, Heisler FF, Gromova KV, Lombino FL, Roesler MK, Pechmann Y, Hornig S, Schweizer M, Polo S, et al.

(7) Sonic hedgehog expression in the postnatal brainBiology openMarch 26, 2019Rivell A, Petralia RS, Wang YX, Clawson E, Moehl K, Mattson MP, Yao PJ.

(8) Modulation of Functional Connectivity Between Dopamine Neurons of the Rat Ventral Tegmental Area in vitroFrontiers in integrative neuroscienceJanuary 1, 2019van der Velden L, Vinck MA, Werkman TR, Wadman WJ.

(9) AMP-Activated Protein Kinase Is Essential for the Maintenance of Energy Levels during Synaptic ActivationiScienceNovember 30, 2018Marinangeli C, Didier S, Ahmed T, Caillerez R, Domise M, Laloux C, Bégard S, Carrier S, Colin M, Marchetti P, et al.

(10) The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal SequencesCell reportsOctober 23, 2018McKay S, Ryan TJ, McQueen J, Indersmitten T, Marwick KFM, Hasel P, Kopanitsa MV, Baxter PS, Martel MA, Kind PC, et al.Tetrodotoxin citrate (TTX),Tocris,Cat# 1069/1 (+)-MK801 maleate,Tocris,Cat# 0924/10 (+)-Bicuculline,Tocris,Cat# 0130/50 Picrotoxin,Tocris,Cat# 1128/1G Spermine,Sigma,Cat# S3256-1G Ifenprodil hemitartrate,Tocris,Cat# 0545/10 ,, Experimental Models

(11) Pauses in Cholinergic Interneuron Activity Are Driven by Excitatory Input and Delayed Rectification, with Dopamine ModulationNeuronJune 6, 2018Zhang YF, Reynolds JNJ, Cragg SJ.

(12) JIP1-Mediated JNK Activation Negatively Regulates Synaptic Plasticity and Spatial MemoryThe Journal of neuroscience : the official journal of the Society for NeuroscienceApril 11, 2018Morel C, Sherrin T, Kennedy NJ, Forest KH, Avcioglu Barutcu S, Robles M, Carpenter-Hyland E, Alfulaij N, Standen CL, Nichols RA, et al.

(13) δ-Subunit Containing GABA_A Receptors Modulate Respiratory NetworksScientific reportsDecember 22, 2017Montandon G, Wu H, Liu H, Vu MT, Orser BA, Horner RL.

(14) Impairments of spatial memory in an Alzheimer's disease model via degeneration of hippocampal cholinergic synapsesNature communicationsNovember 22, 2017Zhu H, Yan H, Tang N, Li X, Pang P, Li H, Chen W, Guo Y, Shu S, Cai Y, et al.

(15) The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal NeuronseNeuroNovember 1, 2017Leal G, Comprido D, de Luca P, Morais E, Rodrigues L, Mele M, Santos AR, Costa RO, Pinto MJ, Patil S, et al.

(16) Artemisinins Target GABA_A Receptor Signaling and Impair α Cell IdentityCellJanuary 12, 2017Li J, Casteels T, Frogne T, Ingvorsen C, Honoré C, Courtney M, Huber KVM, Schmitner N, Kimmel RA, Romanov RA, et al.

(17) Glycinergic dysfunction in a subpopulation of dorsal horn interneurons in a rat model of neuropathic painScientific reportsNovember 14, 2016Imlach WL, Bhola RF, Mohammadi SA, Christie MJ.

(18) Identification of small molecules that improve ATP synthesis defects conferred by Leber's hereditary optic neuropathy mutationsMitochondrionSeptember 1, 2016Datta S, Tomilov A, Cortopassi G.

(19) Phosphorylation state-dependent modulation of spinal glycine receptors alleviates inflammatory painThe Journal of clinical investigationJuly 1, 2016Acuña MA, Yévenes GE, Ralvenius WT, Benke D, Di Lio A, Lara CO, Muñoz B, Burgos CF, Moraga-Cid G, Corringer PJ, et al.

(20) Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampuseLifeMarch 15, 2016Dinamarca MC, Guzzetti F, Karpova A, Lim D, Mitro N, Musardo S, Mellone M, Marcello E, Stanic J, Samaddar T, et al.

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(+)-Bicuculline

(+)-Bicuculline

(+)-Bicuculline from Tocris Bioscience, a Bio-Techne Brand

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Specifications/Features

Tocris Bioscience, a Bio-Techne Brand

Citations (106)

Reviews

(+)-Bicuculline from Tocris Bioscience, a Bio-Techne Brand

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