Torin 2 from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemTorin 2
CompanyTocris Bioscience, a Bio-Techne Brand
Price $291.00Supplier Page View Company Product Page
Catalog Number4248/10
Quantity10 mg (also 50 mg)
Purity98%
Molecular Weight432.4
Molecule Name9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one
FormulaC24H15F3N4O
StorageStore at +4°C

Sizes Available: 10 mg (also 50 mg)

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

(3) RNF43 G659fs is an oncogenic colorectal cancer mutation and sensitizes tumor cells to PI3K/mTOR inhibitionNature communicationsJune 8, 2022Fang L, Ford-Roshon D, Russo M, O'Brien C, Xiong X, Gurjao C, Grandclaudon M, Raghavan S, Corsello SM, Carr SA, et al.

(4) Visual barcodes for clonal-multiplexing of live microscopy-based assaysNature communicationsMay 18, 2022Kaufman T, Nitzan E, Firestein N, Ginzberg MB, Iyengar S, Patel N, Ben-Hamo R, Porat Z, Hunter J, Hilfinger A, et al.

(6) Translation Inhibitors Activate Autophagy Master Regulators TFEB and TFE3International journal of molecular sciencesNovember 8, 2021Dang TT, Back SH.

(8) Comparing mTOR inhibitor Rapamycin with Torin-2 within the RIST molecular-targeted regimen in neuroblastoma cellsInternational journal of medical sciencesJanuary 1, 2021Waetzig R, Matthes M, Leister J, Penkivech G, Heise T, Corbacioglu S, Sommer G.

(9) The Synergistic Effect of an ATP-Competitive Inhibitor of mTOR and Metformin on Pancreatic Tumor GrowthCurrent developments in nutritionSeptember 1, 2020Soliman GA, Shukla SK, Etekpo A, Gunda V, Steenson SM, Gautam N, Alnouti Y, Singh PK.

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(12) Direct Targeting of the mTOR (Mammalian Target of Rapamycin) Kinase Improves Endothelial Permeability in Drug-Eluting Stents-Brief ReportArteriosclerosis, thrombosis, and vascular biologySeptember 1, 2018Harari E, Guo L, Smith SL, Paek KH, Fernandez R, Sakamoto A, Mori H, Kutyna MD, Habib A, Torii S, et al.

(14) SYK kinase mediates brown fat differentiation and activationNature communicationsDecember 13, 2017Knoll M, Winther S, Natarajan A, Yang H, Jiang M, Thiru P, Shahsafaei A, Chavarria TE, Lamming DW, Sun L, et al.

(15) The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System InjuryThe Journal of neuroscience : the official journal of the Society for NeuroscienceJuly 26, 2017Al-Ali H, Ding Y, Slepak T, Wu W, Sun Y, Martinez Y, Xu XM, Lemmon VP, Bixby JL.

(16) Diagnostic and clinical relevance of the autophago-lysosomal network in human gliomasOncotargetApril 12, 2016Jennewein L, Ronellenfitsch MW, Antonietti P, Ilina EI, Jung J, Stadel D, Flohr LM, Zinke J, von Renesse J, Drott U, et al.

(18) Dual Targeting of mTOR Activity with Torin2 Potentiates Anticancer Effects of Cisplatin in Epithelial Ovarian CancerMolecular medicine (Cambridge, Mass.)May 26, 2015Hussain AR, Al-Romaizan M, Ahmed M, Thangavel S, Al-Dayel F, Beg S, Uddin S, Siraj AK, Al-Kuraya KS.

(19) PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylationNature communicationsMay 22, 2015Yu JS, Ramasamy TS, Murphy N, Holt MK, Czapiewski R, Wei SK, Cui W.

Torin 2