G-1 from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemG-1
CompanyTocris Bioscience, a Bio-Techne Brand
Price $290.00Supplier Page View Company Product Page
Catalog Number3577/10
Quantity10 mg
Molecule Name(±)-1-[(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]- ethanone
FormulaC21H18BrNO3
Molecular Weight412.28
Purity98%
StorageStore at -20°C

Sizes Available: 10 mg

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

(1) Anti-Inflammatory Actions of G-Protein-Coupled Estrogen Receptor 1 (GPER) and Brain-Derived Estrogen Following Cerebral Ischemia in Ovariectomized RatsBiologyJanuary 9, 2023Xu J, Bai J, Gao F, Xu C, Huang Y, Li D, Wang L, Wang R.carotid arteries clamped. 2.2. Administration of Drugs GPER agonist G1 (Tocris, Bristol, UK; Cat. No. 3577; 10 μg/day) or GPER antagonist G36 (Tocris; Cat. No. 4759; 10 μg/day) was administrated subcutaneously using

(2) ERα-independent NRF2-mediated immunoregulatory activity of tamoxifenBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapieDecember 1, 2021Pepe G, Sfogliarini C, Rizzello L, Battaglia G, Pinna C, Rovati G, Ciana P, Brunialti E, Mornata F, Maggi A, et al.

(3) GPR30-mediated HMGB1 upregulation in CAFs induces autophagy and tamoxifen resistance in ERα-positive breast cancer cellsAgingJune 28, 2021Liu L, Liu S, Luo H, Chen C, Zhang X, He L, Tu G.reagents were used: rHMGB1 (Cat No. #1690-HMB-050, R&D Systems, Minneapolis, MN, USA), G1 (Cat. No. 3577/10, TOCRIS, Bioscience, Bristol, UK), G15 (Cat. No. 3678/10, TOCRIS, Bioscience, Bristol, UK). E2, TAM,

(4) Utilizing Designed Receptors Exclusively Activated by Designer Drug Chemogenetic Tools to Identify Beneficial G Protein-Coupled Receptor Signaling for FibrosisThe Journal of pharmacology and experimental therapeuticsNovember 1, 2020Zhang J, Vardy E, Muise ES, Wang TM, Visconti R, Vadlamudi A, Pinto S, Peier AM.

(6) Essential and sex-specific effects of mGluR5 in ventromedial hypothalamus regulating estrogen signaling and glucose balanceProceedings of the National Academy of Sciences of the United States of AmericaAugust 11, 2020Fagan MP, Ameroso D, Meng A, Rock A, Maguire J, Rios M.

(7) G-protein-coupled estrogen receptor activation upregulates interleukin-1 receptor antagonist in the hippocampus after global cerebral ischemia: implications for neuronal self-defenseJournal of neuroinflammationFebruary 1, 2020Bai N, Zhang Q, Zhang W, Liu B, Yang F, Brann D, Wang R.except that the CCA were not clamped. Administration of drugs GPER agonist, G1 (Tocris, Cat. No. 3577, 10 μg/day), or/and GPER antagonist, G36 (Tocris, Cat. No. 4759, 10 μg/day) was administrated subcutaneously

(8) GPER Activation Inhibits Cancer Cell Mechanotransduction and Basement Membrane Invasion via RhoACancersJanuary 25, 2020Rice A, Cortes E, Lachowski D, Oertle P, Matellan C, Thorpe SD, Ghose R, Wang H, Lee DA, Plodinec M, et al.

(9) Sex Differences in the Pro-Angiogenic Response of Human Endothelial Cells: Focus on PFKFB3 and FAK ActivationFrontiers in pharmacologyJanuary 1, 2020Boscaro C, Trenti A, Baggio C, Scapin C, Trevisi L, Cignarella A, Bolego C.

(10) Low-dose Bisphenol-A regulates inflammatory cytokines through GPR30 in mammary adipose cellsJournal of molecular endocrinologyNovember 1, 2019Cimmino I, Oriente F, D'Esposito V, Liguoro D, Liguoro P, Ambrosio MR, Cabaro S, D'Andrea F, Beguinot F, Formisano P, et al.

(11) Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptorOncogeneApril 1, 2019Cortes E, Lachowski D, Rice A, Thorpe SD, Robinson B, Yeldag G, Lee DA, Ghemtio L, Rombouts K, Del Río Hernández AE.

(14) Distal Dendritic Enrichment of HCN1 Channels in Hippocampal CA1 Is Promoted by Estrogen, but Does Not Require ReelineNeuroSeptember 1, 2018Meseke M, Neumüller F, Brunne B, Li X, Anstötz M, Pohlkamp T, Rogalla MM, Herz J, Rune GM, Bender RA.

(15) Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiolScientific reportsJanuary 23, 2017Caballero I, Boyd J, Almiñana C, Sánchez-López JA, Basatvat S, Montazeri M, Maslehat Lay N, Elliott S, Spiller DG, White MR, et al.

(16) GPER signalling in both cancer-associated fibroblasts and breast cancer cells mediates a feedforward IL1β/IL1R1 responseScientific reportsApril 13, 2016De Marco P, Lappano R, De Francesco EM, Cirillo F, Pupo M, Avino S, Vivacqua A, Abonante S, Picard D, Maggiolini M.

(19) Estrogen accelerates the resolution of inflammation in macrophagic cellsScientific reportsOctober 19, 2015Villa A, Rizzi N, Vegeto E, Ciana P, Maggi A.

(20) A calixpyrrole derivative acts as an antagonist to GPER, a G-protein coupled receptor: mechanisms and modelsDisease models & mechanismsOctober 1, 2015Lappano R, Rosano C, Pisano A, Santolla MF, De Francesco EM, De Marco P, Dolce V, Ponassi M, Felli L, Cafeo G, et al.

G-1