PP 2 from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemPP 2
CompanyTocris Bioscience, a Bio-Techne Brand
Price $387.00Supplier Page View Company Product Page
Catalog Number1407/10
Purity98%
Molecular Weight301.78
Molecule Name3-(4-chlorophenyl) 1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
FormulaC15H16ClN5
StorageDesiccate at +4°C
Quantity10 mg

Specifications/Features

Sizes Available: 10 mg

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Reelin signaling modulates GABA(B) receptor function in the neocortexJournal of neurochemistryMarch 1, 2021Hamad MIK, Jbara A, Rabaya O, Petrova P, Daoud S, Melliti N, Meseke M, Lutz D, Petrasch-Parwez E, Schwitalla JC, et al.Tocris, Wiesbaden, Germany), CGP35348 (10 μM, Cat# 1245/10, Tocris, Wiesbaden, Germany), PP2 (1 μM, Cat# 1407/10, Tocris, Wiesbaden, Germany), pertussis toxin (PTX, 500 ng/mL, Cat# 3097/50U, Tocris, Wiesbaden, Germany),

(2) Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitorsJournal of enzyme inhibition and medicinal chemistryDecember 1, 2018Poli G, Lapillo M, Granchi C, Caciolla J, Mouawad N, Caligiuri I, Rizzolio F, Langer T, Minutolo F, Tuccinardi T.

(3) Src activation by Chk1 promotes actin patch formation and prevents chromatin bridge breakage in cytokinesisThe Journal of cell biologySeptember 3, 2018Dandoulaki M, Petsalaki E, Sumpton D, Zanivan S, Zachos G.

(4) Loss-of-function mutations in ATP6AP1 and ATP6AP2 in granular cell tumorsNature communicationsAugust 30, 2018Pareja F, Brandes AH, Basili T, Selenica P, Geyer FC, Fan D, Da Cruz Paula A, Kumar R, Brown DN, Gularte-Mérida R, et al.

(5) Estrogen and Progesterone Integration in an in vitro Model of RP3V Kisspeptin NeuronsNeuroendocrinologyJanuary 1, 2018Mittelman-Smith MA, Wong AM, Micevych PE.

(6) A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cellsNature communicationsMarch 23, 2017Walko G, Woodhouse S, Pisco AO, Rognoni E, Liakath-Ali K, Lichtenberger BM, Mishra A, Telerman SB, Viswanathan P, Logtenberg M, et al.

(7) Increased NRG1-ErbB4 signaling in human symptomatic epilepsyScientific reportsMarch 10, 2017Zhu JM, Li KX, Cao SX, Chen XJ, Shen CJ, Zhang Y, Geng HY, Chen BQ, Lian H, Zhang JM, et al.

(8) Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 ExpressionTheranosticsJanuary 1, 2017Li X, Chen W, Li P, Wei J, Cheng Y, Liu P, Yan Q, Xu X, Cui Y, Gu Z, et al.

(9) Mathematical model of early Reelin-induced Src family kinase-mediated signalingPloS oneJanuary 1, 2017Hass H, Kipkeew F, Gauhar A, Bouché E, May P, Timmer J, Bock HH.

(10) Intrinsic Photosensitivity Enhances Motility of T LymphocytesScientific reportsDecember 20, 2016Phan TX, Jaruga B, Pingle SC, Bandyopadhyay BC, Ahern GP.

(11) Smooth muscle contraction and growth of stromal cells in the human prostate are both inhibited by the Src family kinase inhibitors, AZM475271 and PP2British journal of pharmacologyDecember 1, 2016Wang Y, Gratzke C, Tamalunas A, Rutz B, Ciotkowska A, Strittmatter F, Herlemann A, Janich S, Waidelich R, Liu C, et al.

(12) A high-content EMT screen identifies multiple receptor tyrosine kinase inhibitors with activity on TGFβ receptorOncotargetMay 3, 2016Lotz-Jenne C, Lüthi U, Ackerknecht S, Lehembre F, Fink T, Stritt M, Wirth M, Pavan S, Bill R, Regenass U, et al.

(13) Sonic hedgehog stimulates neurite outgrowth in a mechanical stretch model of reactive-astrogliosisScientific reportsFebruary 23, 2016Berretta A, Gowing EK, Jasoni CL, Clarkson AN.

(14) Presynaptic GABAB receptors reduce transmission at parabrachial synapses in the lateral central amygdala by inhibiting N-type calcium channelsScientific reportsJanuary 12, 2016Delaney AJ, Crane JW.

(15) Progesterone receptor membrane component-1 regulates hepcidin biosynthesisThe Journal of clinical investigationJanuary 1, 2016Li X, Rhee DK, Malhotra R, Mayeur C, Hurst LA, Ager E, Shelton G, Kramer Y, McCulloh D, Keefe D, et al.

(16) Extracellular galectin-3 programs multidrug resistance through Na+/K+-ATPase and P-glycoprotein signalingOncotargetAugust 14, 2015Harazono Y, Kho DH, Balan V, Nakajima K, Hogan V, Raz A.

(17) Anoikis resistance is a critical feature of highly aggressive ovarian cancer cellsOncogeneJune 1, 2015Cai Q, Yan L, Xu Y.

(18) Tyrosine phosphorylation of WIP releases bound WASP and impairs podosome assembly in macrophagesJournal of cell scienceJanuary 15, 2015Vijayakumar V, Monypenny J, Chen XJ, Machesky LM, Lilla S, Thrasher AJ, Antón IM, Calle Y, Jones GE.

(19) The prion protein constitutively controls neuronal store-operated Ca(2+) entry through Fyn kinaseFrontiers in cellular neuroscienceJanuary 1, 2015De Mario A, Castellani A, Peggion C, Massimino ML, Lim D, Hill AF, Sorgato MC, Bertoli A.

(20) Long-term treatment with PP2 after spinal cord injury resulted in functional locomotor recovery and increased spared tissueNeural regeneration researchDecember 15, 2014Rosas OR, Torrado AI, Santiago JM, Rodriguez AE, Salgado IK, Miranda JD.

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PP 2

PP 2 from Tocris Bioscience, a Bio-Techne Brand

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Specifications/Features

Tocris Bioscience, a Bio-Techne Brand

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PP 2 from Tocris Bioscience, a Bio-Techne Brand

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