SB 203580 from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemSB 203580
CompanyTocris Bioscience, a Bio-Techne Brand
Price $158.00Supplier Page View Company Product Page
Catalog Number1202/1
Quantity1 mg (also 10 mg, 50 mg)
Purity98%
Molecular Weight377.44
Molecule Name4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine
FormulaC21H16FN3OS
StorageStore at +4°C

Specifications/Features

Sizes Available: 1 mg (also 10 mg, 50 mg)

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) α-Synuclein Degradation in Brain Pericytes Is Mediated via Akt, ERK, and p38 MAPK Signaling PathwaysInt J Mol SciFebruary 14, 2025Miki Yokoya, Fuyuko Takata, Takuro Iwao, Junichi Matsumoto, Yasuyoshi Tanaka, Hisataka Aridome, Miho Yasunaga, Junko Mizoguchi, Kazunori Sano, Shinya DohguμM, Tocris, Ellisville, MO, USA; 1130/5), U0126 (10 μM, Tocris; 1144/5), and SB203580 (10 μM, Tocris; 1202/1) in serum-free DMEM or physiological buffer for the indicated time at 37 °C. Drugs were dissolved in

(2) Scratch wound-induced CXCL8 upregulation is EGFR-dependent in keratinocytesJournal of dermatological scienceSeptember 1, 2020Furue K, Ito T, Tsuji G, Nakahara T, Furue M.

(3) The EGFR-ERK/JNK-CCL20 Pathway in Scratched Keratinocytes May Underpin Koebnerization in Psoriasis PatientsInternational journal of molecular sciencesJanuary 9, 2020Furue K, Ito T, Tanaka Y, Hashimoto-Hachiya A, Takemura M, Murata M, Kido-Nakahara M, Tsuji G, Nakahara T, Furue M.

(4) Combination of metformin and p38 MAPK inhibitor, SB203580, reduced myocardial ischemia/reperfusion injury in non-obese type 2 diabetic Goto-Kakizaki ratsExperimental and therapeutic medicineSeptember 1, 2019Sanit J, Prompunt E, Adulyaritthikul P, Nokkaew N, Mongkolpathumrat P, Kongpol K, Kijtawornrat A, Petchdee S, Barrère-Lemaire S, Kumphune S.

(5) Interleukin (IL)-22 from IL-20 Subfamily of Cytokines Induces Colonic Epithelial Cell Proliferation Predominantly through ERK1/2 PathwayInternational journal of molecular sciencesJuly 15, 2019Moniruzzaman M, Wang R, Jeet V, McGuckin MA, Hasnain SZ.

(6) Whole Genome Microarray Analysis of DUSP4-Deletion Reveals A Novel Role for MAP Kinase Phosphatase-2 (MKP-2) in Macrophage Gene Expression and FunctionInternational journal of molecular sciencesJuly 12, 2019Neamatallah T, Jabbar S, Tate R, Schroeder J, Shweash M, Alexander J, Plevin R.

(7) Scratching Counteracts IL-13 Signaling by Upregulating the Decoy Receptor IL-13Rα2 in KeratinocytesInternational journal of molecular sciencesJuly 6, 2019Ulzii D, Kido-Nakahara M, Nakahara T, Tsuji G, Furue K, Hashimoto-Hachiya A, Furue M.

(8) Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic PainCell reportsJune 25, 2019Zhou LJ, Peng J, Xu YN, Zeng WJ, Zhang J, Wei X, Mai CL, Lin ZJ, Liu Y, Murugan M, et al.

(9) HIV gp120 upregulates tonic inhibition through α5-containing GABA_ARsNeuropharmacologyMay 1, 2019Green MV, Thayer SA.

(10) Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activationMolecular visionJanuary 1, 2019Messerschmidt L, Fischer S, Wiedemann P, Bringmann A, Hollborn M.

(11) LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microgliaPloS oneJanuary 1, 2019Kim J, Pajarillo E, Rizor A, Son DS, Lee J, Aschner M, Lee E.

(12) Improving Cell Survival in Injected Embryos Allows Primed Pluripotent Stem Cells to Generate Chimeric Cynomolgus MonkeysCell reportsNovember 27, 2018Kang Y, Ai Z, Duan K, Si C, Wang Y, Zheng Y, He J, Yin Y, Zhao S, Niu B, et al.

(13) Decreased Expression of TRPV4 Channels in HEI-OC1 Cells Induced by High Glucose Is Associated with Hearing ImpairmentYonsei medical journalNovember 1, 2018Xing Y, Ming J, Liu T, Zhang N, Zha D, Lin Y.

(14) Interleukin-1β induces CXCR3-mediated chemotaxis to promote umbilical cord mesenchymal stem cell transendothelial migrationStem cell research & therapyOctober 25, 2018Guo YC, Chiu YH, Chen CP, Wang HS.

(15) Molecular mechanisms of IL-33-mediated stromal interactions in cancer metastasisJCI insightOctober 18, 2018Andersson P, Yang Y, Hosaka K, Zhang Y, Fischer C, Braun H, Liu S, Yu G, Liu S, Beyaert R, et al.

(16) The p38α Stress Kinase Suppresses Aneuploidy Tolerance by Inhibiting Hif-1αCell reportsOctober 16, 2018Simões-Sousa S, Littler S, Thompson SL, Minshall P, Whalley H, Bakker B, Belkot K, Moralli D, Bronder D, Tighe A, et al.

(17) Hypertonic Stress Causes Cytoplasmic Translocation of Neuronal, but Not Astrocytic, FUS due to Impaired Transportin FunctionCell reportsJuly 24, 2018Hock EM, Maniecka Z, Hruska-Plochan M, Reber S, Laferrière F, Sahadevan M K S, Ederle H, Gittings L, Pelkmans L, Dupuis L, et al.

(18) Differential effect of p38 and MK2 kinase inhibitors on the inflammatory and toxicity biomarkers in vitroHuman & experimental toxicologyMay 1, 2018Singh RK, Diwan M, Dastidar SG, Najmi AK.

(19) Suppressive effects of berberine on atherosclerosis via downregulating visfatin expression and attenuating visfatin-induced endothelial dysfunctionInternational journal of molecular medicineApril 1, 2018Wan Q, Liu Z, Yang Y, Cui X.

(20) Capsaicin-induced TRIB3 upregulation promotes apoptosis in cancer cellsCancer management and researchJanuary 1, 2018Lin RJ, Wu IJ, Hong JY, Liu BH, Liang RY, Yuan TM, Chuang SM.

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SB 203580

SB 203580 from Tocris Bioscience, a Bio-Techne Brand

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Specifications/Features

Tocris Bioscience, a Bio-Techne Brand

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SB 203580 from Tocris Bioscience, a Bio-Techne Brand

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