API-2 2151/10 from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemAPI-2
CompanyTocris Bioscience, a Bio-Techne Brand
Price $400.00Supplier Page View Company Product Page
Catalog Number2151/10
Size10 mg
Purity98%
Molecular Weight320.31
Molecule Name1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine
FormulaC13H16N6O4
StorageStore at RT

Specifications/Features

Sizes Available: 10 mg

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) IFT80 is required for stem cell proliferation, differentiation, and odontoblast polarization during tooth developmentCell death & diseaseJanuary 25, 2019Yuan X, Cao X, Yang S.

(2) The AKT inhibitor triciribine in combination with paclitaxel has order-specific efficacy against Zfp217-induced breast cancer chemoresistanceOncotargetDecember 12, 2017Suarez CD, Wu J, Badve SS, Sparano JA, Kaliney W, Littlepage LE.

(3) Isolation and characterization of a new naturally immortalized human breast carcinoma cell line, KAIMRC1BMC cancerNovember 29, 2017Ali R, Samman N, Al Zahrani H, Nehdi A, Rahman S, Khan AL, Al Balwi M, Alriyees LA, Alzaid M, Al Askar A, et al.response effect Doxorubicin hydrochloride (Cat. No. 2252), Letrozole (Cat. No. 4382), API-2 (Cat. No. 2151), 10-DEBC hydrochloride (Cat. No. 2558), and LY294002 hydrochloride (Cat. No. 1130) were used. All compounds

(4) Tankyrase Inhibition Blocks Wnt/β-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal CancerClinical cancer research : an official journal of the American Association for Cancer ResearchFebruary 1, 2016Arqués O, Chicote I, Puig I, Tenbaum SP, Argilés G, Dienstmann R, Fernández N, Caratù G, Matito J, Silberschmidt D, et al.

(5) PI3K Phosphorylation Is Linked to Improved Electrical Excitability in an In Vitro Engineered Heart Tissue Disease Model SystemTissue engineering. Part ASeptember 1, 2015Kana K, Song H, Laschinger C, Zandstra PW, Radisic M.

(6) Phenylbutyrate induces cathelicidin expression via the vitamin D receptor: Linkage to inflammatory and growth factor cytokines pathwaysMolecular immunologyFebruary 1, 2015Kulkarni NN, Yi Z, Huehnken C, Agerberth B, Gudmundsson GH.

(7) Targeting Glutamatergic Signaling and the PI3 Kinase Pathway to Halt Melanoma ProgressionTranslational oncologyFebruary 1, 2015Rosenberg SA, Niglio SA, Salehomoum N, Chan JL, Jeong BS, Wen Y, Li J, Fukui J, Chen S, Shin SS, et al.

(8) Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by insulinJournal of lipid researchMay 1, 2014Kuo T, Chen TC, Yan S, Foo F, Ching C, McQueen A, Wang JC.

(9) AKT hyperactivation confers a Th1 phenotype in thymic Treg cells deficient in TGF-β receptor II signalingEuropean journal of immunologyFebruary 1, 2014Liu Y, Xu Y, Sun J, Ma A, Zhang F, Xia S, Xu G, Liu Y.

(10) Propofol mediates signal transducer and activator of transcription 3 activation and crosstalk with phosphoinositide 3-kinase/AKTJAK-STATJanuary 1, 2014Shravah J, Wang B, Pavlovic M, Kumar U, Chen DD, Luo H, Ansley DM.

(11) A personalized preclinical model to evaluate the metastatic potential of patient-derived colon cancer initiating cellsClinical cancer research : an official journal of the American Association for Cancer ResearchDecember 15, 2013Puig I, Chicote I, Tenbaum SP, Arqués O, Herance JR, Gispert JD, Jimenez J, Landolfi S, Caci K, Allende H, et al.

(12) Sea urchin akt activity is Runx-dependent and required for post-cleavage stage cell divisionBiology openMay 15, 2013Robertson AJ, Coluccio A, Jensen S, Rydlizky K, Coffman JA.

(13) β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancerNature medicineJune 1, 2012Tenbaum SP, Ordóñez-Morán P, Puig I, Chicote I, Arqués O, Landolfi S, Fernández Y, Herance JR, Gispert JD, Mendizabal L, et al.

(14) Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular traffickingThe Journal of biological chemistryFebruary 3, 2012Woo MG, Xue K, Liu J, McBride H, Tsang BK.

(15) mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTORMolecular cellOctober 21, 2011Duan S, Skaar JR, Kuchay S, Toschi A, Kanarek N, Ben-Neriah Y, Pagano M.

(16) NKG2D receptor regulates human effector T-cell cytokine productionBloodJune 16, 2011Barber A, Sentman CL.

(17) FRP inhibits ox-LDL-induced endothelial cell apoptosis through an Akt-NF-{kappa}B-Bcl-2 pathway and inhibits endothelial cell apoptosis in an apoE-knockout mouse modelAmerican journal of physiology. Endocrinology and metabolismSeptember 1, 2010Liu S, Shen H, Xu M, Liu O, Zhao L, Liu S, Guo Z, Du J.

(18) Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinasePloS oneAugust 4, 2010Jackson C, Welch HC, Bellamy TC.

(19) Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 receptor-independent activation of beta-catenin signalingThe Journal of biological chemistryMarch 19, 2010Sunters A, Armstrong VJ, Zaman G, Kypta RM, Kawano Y, Lanyon LE, Price JS.

(20) Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathwaysPloS oneJune 23, 2009Roselli F, Hutzler P, Wegerich Y, Livrea P, Almeida OF.

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API-2

API-2 from Tocris Bioscience, a Bio-Techne Brand

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Specifications/Features

Tocris Bioscience, a Bio-Techne Brand

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API-2 from Tocris Bioscience, a Bio-Techne Brand

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