PHA 665752 from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemPHA 665752
CompanyTocris Bioscience, a Bio-Techne Brand
Price $421.00Supplier Page View Company Product Page
Catalog Number2693/10
Quantity10 mg (also 50 mg)
Purity98%
Molecular Weight641.61
Molecule Name(2R)-1-[[5-[(Z)-[5-[[(2,6-Dichlorophenyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carbonyl]-2-(1-pyrrolidinylmethyl)pyrrolidine
FormulaC32H34Cl2N4O4S
StorageStore at +4°C

Sizes Available: 10 mg (also 50 mg)

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

(2) Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory painNature communicationsAugust 2, 2017Paldy E, Simonetti M, Worzfeld T, Bali KK, Vicuña L, Offermanns S, Kuner R.

(3) Genomic and Molecular Screenings Identify Different Mechanisms for Acquired Resistance to MET Inhibitors in Lung Cancer CellsMolecular cancer therapeuticsJuly 1, 2017Gimenez-Xavier P, Pros E, Bonastre E, Moran S, Aza A, Graña O, Gomez-Lopez G, Derdak S, Dabad M, Esteve-Codina A, et al.

(4) MET inhibition overcomes radiation resistance of glioblastoma stem-like cellsEMBO molecular medicineMay 1, 2016De Bacco F, D'Ambrosio A, Casanova E, Orzan F, Neggia R, Albano R, Verginelli F, Cominelli M, Poliani PL, Luraghi P, et al.

(7) YangZheng XiaoJi exerts anti-tumour growth effects by antagonising the effects of HGF and its receptor, cMET, in human lung cancer cellsJournal of translational medicineAugust 27, 2015Jiang WG, Ye L, Ruge F, Owen S, Martin T, Sun PH, Sanders AJ, Lane J, Satherley L, Weeks HP, et al.

(8) Influenza induces IL-8 and GM-CSF secretion by human alveolar epithelial cells through HGF/c-Met and TGF-α/EGFR signalingAmerican journal of physiology. Lung cellular and molecular physiologyJune 1, 2015Ito Y, Correll K, Zemans RL, Leslie CC, Murphy RC, Mason RJ.

(9) Disentangling the Complexity of HGF Signaling by Combining Qualitative and Quantitative ModelingPLoS computational biologyApril 1, 2015D'Alessandro LA, Samaga R, Maiwald T, Rho SH, Bonefas S, Raue A, Iwamoto N, Kienast A, Waldow K, Meyer R, et al.

(10) Effects of AKT inhibition on HGF-mediated erlotinib resistance in non-small cell lung cancer cell linesJournal of cancer research and clinical oncologyApril 1, 2015Holland WS, Chinn DC, Lara PN Jr, Gandara DR, Mack PC.

(11) The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinomaBMC cancerFebruary 25, 2015Saito S, Morishima K, Ui T, Hoshino H, Matsubara D, Ishikawa S, Aburatani H, Fukayama M, Hosoya Y, Sata N, et al.

(13) Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-βProceedings of the National Academy of Sciences of the United States of AmericaMay 27, 2014Wiener Z, Band AM, Kallio P, Högström J, Hyvönen V, Kaijalainen S, Ritvos O, Haglund C, Kruuna O, Robine S, et al.

(14) Multipoint targeting of the PI3K/mTOR pathway in mesotheliomaBritish journal of cancerMay 13, 2014Zhou S, Liu L, Li H, Eilers G, Kuang Y, Shi S, Yan Z, Li X, Corson JM, Meng F, et al.

(16) A common p53 mutation (R175H) activates c-Met receptor tyrosine kinase to enhance tumor cell invasionCancer biology & therapySeptember 1, 2013Grugan KD, Vega ME, Wong GS, Diehl JA, Bass AJ, Wong KK, Nakagawa H, Rustgi AK.

(18) Cytotoxic activity of tivantinib (ARQ 197) is not due solely to c-MET inhibitionCancer researchMay 15, 2013Katayama R, Aoyama A, Yamori T, Qi J, Oh-hara T, Song Y, Engelman JA, Fujita N.

(19) Tivantinib (ARQ197) displays cytotoxic activity that is independent of its ability to bind METClinical cancer research : an official journal of the American Association for Cancer ResearchMay 1, 2013Basilico C, Pennacchietti S, Vigna E, Chiriaco C, Arena S, Bardelli A, Valdembri D, Serini G, Michieli P.

PHA 665752