NSC 23766 from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemNSC 23766
CompanyTocris Bioscience, a Bio-Techne Brand
Price $227.00Supplier Page View Company Product Page
Catalog Number2161/10
Purity98%
Molecular Weight530.97
Molecule NameN6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride
FormulaC24H35N7.3HCl
StorageDesiccate at RT
Quantity10 mg (also 50 mg)

Specifications/Features

Sizes Available: 10 mg (also 50 mg)

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Time of Day-Dependent Alteration of Hippocampal Rac1 Activation Regulates Contextual Fear Memory in RatsFrontiers in Molecular NeuroscienceJune 16, 2022Lizhu Jiang, Chao Liu, Baizhen Zhao, Chen Ma, Yan Yin, Qixin Zhou, Lin Xu, RongRong Maoμg/μl) and diluted in normal saline to the desired concentration (2 μg/μl), and NSC 23766 (TOCRIS, 2161–10 mg) was dissolved in saline to the working concentration (0.5 μg/μl) immediately before administration.

(2) Human macrophage C‐type lectin forms a heteromeric receptor complex with Mincle but not Dectin‐2Scandinavian Journal of ImmunologyMay 1, 2022Vera Blankson, Ana Lobato‐Pascual, Per Christian Saether, Sigbjørn Fossum, Erik Dissen, Michael R. Dawsherein were anti‐hMincle (AT16E3, Acris Antibodies); anti‐hMCL (clone #413512), anti‐hDCIR (clone #216110) and anti‐hDectin‐2 (clone #545925) (all R&D Systems); anti‐FLAG (M2, Sigma‐Aldrich); and anti‐HA (16B12,

(3) Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cellsNature CommunicationsDecember 1, 2021Jake W. Rhodes et al.µl/100 µl. R&D Systems: CD299 (L-SIGN; DC-SIGNR) PE (120604) 2 µl/100 µl, CD367 (Clec4A; DCIR) PE (216110) 4 µl/100 µl, CD368 (Clec4D) PE (413512) 2 µl/100 µl, Clec5A APC (283834) 3 µl/100 µl, Clec5C APC (239127)

(4) RAC1^P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy ResistanceCancer cellJuly 8, 2019Lionarons DA, Hancock DC, Rana S, East P, Moore C, Murillo MM, Carvalho J, Spencer-Dene B, Herbert E, Stamp G, et al.

(5) Non-canonical Wnt signaling regulates junctional mechanocoupling during angiogenic collective cell migrationeLifeJune 27, 2019Carvalho JR, Fortunato IC, Fonseca CG, Pezzarossa A, Barbacena P, Dominguez-Cejudo MA, Vasconcelos FF, Santos NC, Carvalho FA, Franco CA.

(6) Identification of HIV transmitting CD11c⁺ human epidermal dendritic cellsNature communicationsJune 21, 2019Bertram KM, Botting RA, Baharlou H, Rhodes JW, Rana H, Graham JD, Patrick E, Fletcher J, Plasto TM, Truong NR, et al.MR PE (3.29B1.10). eBioscience: CD91 eFluor660 (A2MRa2). R&D Systems: L-SIGN PE (120604), DCIR PE (216110), Clec4D PE (413512), Clec4G APC (845404), Clec5A APC (283834), Clec5C APC (239127), Clec6A APC (545943), Clec10A

(7) Bladder cancer extracellular vesicles drive tumorigenesis by inducing the unfolded protein response in endoplasmic reticulum of nonmalignant cellsThe Journal of biological chemistryMarch 1, 2019Wu CH, Silvers CR, Messing EM, Lee YF.

(8) Matrix mechanical plasticity regulates cancer cell migration through confining microenvironmentsNature communicationsOctober 8, 2018Wisdom KM, Adebowale K, Chang J, Lee JY, Nam S, Desai R, Rossen NS, Rafat M, West RB, Hodgson L, et al.

(9) Chlamydia exploits filopodial capture and a macropinocytosis-like pathway for host cell entryPLoS pathogensMay 1, 2018Ford C, Nans A, Boucrot E, Hayward RD.

(10) In vivo imaging of emerging endocrine cells reveals a requirement for PI3K-regulated motility in pancreatic islet morphogenesisDevelopment (Cambridge, England)February 8, 2018Freudenblum J, Iglesias JA, Hermann M, Walsen T, Wilfinger A, Meyer D, Kimmel RA.

(11) Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machineryeLifeDecember 22, 2017Chang TY, Chen C, Lee M, Chang YC, Lu CH, Lu ST, Wang DY, Wang A, Guo CL, Cheng PL.

(12) The P2X7 receptor is an upstream regulator of dynamic blebbing and a pluripotency marker in human embryonic stem cellsStem cell researchAugust 1, 2017Weng NJ, Talbot P.

(13) The Small GTPase Rac1 Contributes to Extinction of Aversive Memories of Drug Withdrawal by Facilitating GABA_A Receptor Endocytosis in the vmPFCThe Journal of neuroscience : the official journal of the Society for NeuroscienceJuly 26, 2017Wang W, Ju YY, Zhou QX, Tang JX, Li M, Zhang L, Kang S, Chen ZG, Wang YJ, Ji H, et al.

(14) Phenotypic and functional consequences of different isolation protocols on skin mononuclear phagocytesJournal of leukocyte biologyJune 1, 2017Botting RA, Bertram KM, Baharlou H, Sandgren KJ, Fletcher J, Rhodes JW, Rana H, Plasto TM, Wang XM, Lim JJK, et al.PE (3.29B1.10); eBioscience: CD91 eFluor660 (A2MR-a2); and R&D Systems: L-SIGN PE (120604), DCIR PE (216110), Clec4D PE (413512), Clec4G APC (845404), Clec5A APC (283834), Clec5C APC (239127), Clec6A APC (545943),

(15) Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factorsNature communicationsMay 19, 2017Benedicto I, Lehmann GL, Ginsberg M, Nolan DJ, Bareja R, Elemento O, Salfati Z, Alam NM, Prusky GT, Llanos P, et al.

(16) VE-Cadherin Disassembly and Cell Contractility in the Endothelium are Necessary for Barrier Disruption Induced by Tumor CellsScientific reportsApril 10, 2017Aragon-Sanabria V, Pohler SE, Eswar VJ, Bierowski M, Gomez EW, Dong C.

(17) N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cellsNature materialsDecember 1, 2016Cosgrove BD, Mui KL, Driscoll TP, Caliari SR, Mehta KD, Assoian RK, Burdick JA, Mauck RL.

(18) The effects of cytotoxic necrotizing factor 1 expression in the uptake of Escherichia coli K1 by macrophages and the onset of meningitis in newborn miceVirulenceOctober 2, 2016Chang AC, Krishnan S, Prasadarao NV.

(19) WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signalingFASEB journal : official publication of the Federation of American Societies for Experimental BiologyApril 1, 2016Abedini A, Zamberlam G, Lapointe E, Tourigny C, Boyer A, Paquet M, Hayashi K, Honda H, Kikuchi A, Price C, et al.

(20) Synergism of MSC-secreted HGF and VEGF in stabilising endothelial barrier function upon lipopolysaccharide stimulation via the Rac1 pathwayStem cell research & therapyDecember 16, 2015Yang Y, Chen QH, Liu AR, Xu XP, Han JB, Qiu HB.

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NSC 23766

NSC 23766 from Tocris Bioscience, a Bio-Techne Brand

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Specifications/Features

Tocris Bioscience, a Bio-Techne Brand

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NSC 23766 from Tocris Bioscience, a Bio-Techne Brand

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