Torin 1 from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemTorin 1
CompanyTocris Bioscience, a Bio-Techne Brand
Price $378.00Supplier Page View Company Product Page
Catalog Number4247/10
Quantity10 mg (also 50 mg)
Purity98%
Molecular Weight607.62
Molecule Name1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
FormulaC35H28F3N5O2
StorageStore at +4°C

Specifications/Features

Sizes Available: 10 mg (also 50 mg)

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Integrative analysis of drug-gene signatures in human pluripotent stem cells reveals prazosin as a novel SQSTM1 regulator for ALS therapeuticsStem Cell ReportsJuly 14, 2026Florine Roussange, Jacqueline Gide, Johana Tournois, Michel Cailleret, Anne Boland, Christophe Battail, Jean-François Deleuze, Hélène Polvèche, Didier Auboeuf, Knut Brockmann, et al.from Selleckchem. Prazosin (P7791) and alfuzosin (A0232) were purchased from Sigma-Aldrich®. Torin-1 (4247/10) and terazosin (1506/50) were purchased from Tocris. Bafilomycin A (HY100558) was purchased from MedChemExpress. Origin

(2) TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascadeNature CommunicationsApril 1, 2026Yan Xiong, Jaiprakash Sharma, Meggie N. Young, Wen Xiong, Ali Jazayeri, Karl F. Poncha, Ma. Xenia G. Ilagan, Qing Wang, Bei Gao, Hui Zheng, et al.anti-mouse antibody Alexa Fluor™ 488 (Cat# A-11001) (1:400) were from Invitrogen. Reagents Torin 1 (Cat# 424710) was from Tocris; DMSO (Cat# D8418), Tumor Necrosis Factor-α (TNFα) (Cat# H8916), cycloheximide (Cat#

(3) SLC16a6, mTORC1, and Autophagy Regulate Ketone Body Excretion in the Intestinal CellsBiology (Basel)November 26, 2023Takashi Uebanso, Moeka Fukui, Chisato Naito, Takaaki Shimohata, Kazuaki Mawatari, Akira Takahashi(Sigma-Aldrich C5038), wy-14643 (Sigma-Aldrich C7081), torin1 (R and D Systems, Minneapolis, MN, USA, 4247/10), bafilomycin A (Cayman Chemical, Ann Arbor, MI, USA, 11038), chloroquine (Sigma-Aldrich 6628), torin2

(4) Defects in lysosomal function and lipid metabolism in human microglia harboring a TREM2 loss of function mutationActa neuropathologicaJune 1, 2023Filipello F, You SF, Mirfakhar FS, Mahali S, Bollman B, Acquarone M, Korvatska O, Marsh JA, Sivaraman A, Martinez R, et al.

(5) RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndromeNature communicationsMay 15, 2023Sambri I, Ferniani M, Campostrini G, Testa M, Meraviglia V, de Araujo MEG, Dokládal L, Vilardo C, Monfregola J, Zampelli N, et al.

(6) TFEB-dependent lysosome biogenesis is required for senescenceThe EMBO journalMay 2, 2023Curnock R, Yalci K, Palmfeldt J, Jäättelä M, Liu B, Carroll B.

(7) TFEB-mediated lysosomal exocytosis alleviates high-fat diet-induced lipotoxicity in the kidneyJCI insightFebruary 22, 2023Nakamura J, Yamamoto T, Takabatake Y, Namba-Hamano T, Minami S, Takahashi A, Matsuda J, Sakai S, Yonishi H, Maeda S, et al.

(8) Transcriptome, proteome, and protein synthesis within the intracellular cytomatrixiScienceFebruary 17, 2023Shaiken TE, Grimm SL, Siam M, Williams A, Rezaeian AH, Kraushaar D, Ricco E, Robertson MJ, Coarfa C, Jain A, et al.K858,Tocris Bioscience,Cat# 4960/1 Dynarrestin,Tocris Bioscience,Cat# 6526/5 Torin 1,Tocris Bioscience,Cat# 4247/10 PF4708671,Tocris Bioscience,Cat# 4032/5 Bio,Tocris Bioscience,Cat# 3194/10 Rotenone,Tocris Bioscience,Cat#

(9) Selective Eradication of Colon Cancer Cells Harboring PI3K and/or MAPK Pathway Mutations in 3D Culture by Combined PI3K/AKT/mTOR Pathway and MEK InhibitionInternational journal of molecular sciencesJanuary 14, 2023Atanasova VS, Riedl A, Strobl M, Flandorfer J, Unterleuthner D, Weindorfer C, Neuhold P, Stang S, Hengstschläger M, Bergmann M, et al.

(10) A central role for regulated protein stability in the control of TFE3 and MITF by nutrientsMolecular cellJanuary 5, 2023Nardone C, Palanski BA, Scott DC, Timms RT, Barber KW, Gu X, Mao A, Leng Y, Watson EV, Schulman BA, et al.

(11) DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagyBrain : a journal of neurologyDecember 19, 2022Imberechts D, Kinnart I, Wauters F, Terbeek J, Manders L, Wierda K, Eggermont K, Madeiro RF, Sue C, Verfaillie C, et al.

(12) Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complexiScienceNovember 18, 2022McNamara MC, Hosios AM, Torrence ME, Zhao T, Fraser C, Wilkinson M, Kwiatkowski DJ, Henske EP, Wu CL, Sarosiek KA, et al.

(13) SETD2 transcriptional control of ATG14L/S isoforms regulates autophagosome-lysosome fusionCell death & diseaseNovember 12, 2022González-Rodríguez P, Delorme-Axford E, Bernard A, Keane L, Stratoulias V, Grabert K, Engskog-Vlachos P, Füllgrabe J, Klionsky DJ, Joseph B.

(14) The FACT complex facilitates expression of lysosomal and antioxidant genes through binding to TFEB and TFE3AutophagyOctober 1, 2022Jeong E, Martina JA, Contreras PS, Lee J, Puertollano R.

(15) 3D chromatin remodeling potentiates transcriptional programs driving cell invasionProceedings of the National Academy of Sciences of the United States of AmericaSeptember 6, 2022Lebeau B, Jangal M, Zhao T, Wong CK, Wong N, Cañedo EC, Hébert S, Aguilar-Mahecha A, Chabot C, Buchanan M, et al.

(16) Novel Regulators of Macropinocytosis-Dependent Growth Revealed by Informer Set Library Screening in Pancreatic Cancer CellsMetabolitesSeptember 2, 2022Kim SH, Song JH, Kim MJ, Song MG, Ku AA, Bandyopadhyay S, McCormick F, Kim SE.

(17) mTORC1 controls Golgi architecture and vesicle secretion by phosphorylation of SCYL1Nature communicationsAugust 10, 2022Kaeser-Pebernard S, Vionnet C, Mari M, Sankar DS, Hu Z, Roubaty C, Martínez-Martínez E, Zhao H, Spuch-Calvar M, Petri-Fink A, et al.

(18) A pulse-chasable reporter processing assay for mammalian autophagic flux with HaloTageLifeAugust 8, 2022Yim WW, Yamamoto H, Mizushima N.

(19) Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISRCell reportsJuly 19, 2022Krokowski D, Jobava R, Szkop KJ, Chen CW, Fu X, Venus S, Guan BJ, Wu J, Gao Z, Banaszuk W, et al.

(20) Compounds activating VCP D1 ATPase enhance both autophagic and proteasomal neurotoxic protein clearanceNature communicationsJuly 16, 2022Wrobel L, Hill SM, Djajadikerta A, Fernandez-Estevez M, Karabiyik C, Ashkenazi A, Barratt VJ, Stamatakou E, Gunnarsson A, Rasmusson T, et al.

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Torin 1

Torin 1 from Tocris Bioscience, a Bio-Techne Brand

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Specifications/Features

Tocris Bioscience, a Bio-Techne Brand

Citations (269)

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Torin 1 from Tocris Bioscience, a Bio-Techne Brand

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