IPA 3 from Tocris Bioscience, a Bio-Techne Brand

Sizes Available: 10 mg (also 50 mg)

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

(1) Group I p21-activated kinases in leukemia cell adhesion to fibronectinCell adhesion & migrationDecember 1, 2021Kuželová K, Obr A, Röselová P, Grebeňová D, Otevřelová P, Brodská B, Holoubek A.

(2) Kinases of the Focal Adhesion Complex Contribute to Cardiomyocyte SpecificationInternational journal of molecular sciencesSeptember 28, 2021Robert S, Flowers M, Ogle BM.

(4) Interrogation of kinase genetic interactions provides a global view of PAK1-mediated signal transduction pathwaysThe Journal of biological chemistryDecember 11, 2020Kim JH, Seo Y, Jo M, Jeon H, Kim YS, Kim EJ, Seo D, Lee WH, Kim SR, Yachie N, et al.

(6) PAK1 inhibitor IPA-3 mitigates metastatic prostate cancer-induced bone remodelingBiochemical pharmacologyJuly 1, 2020Verma A, Artham S, Alwhaibi A, Adil MS, Cummings BS, Somanath PR.

(7) CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic VesiclesCell reportsFebruary 18, 2020Ivanova D, Imig C, Camacho M, Reinhold A, Guhathakurta D, Montenegro-Venegas C, Cousin MA, Gundelfinger ED, Rosenmund C, Cooper B, et al.

(8) Macropinocytosis drives T cell growth by sustaining the activation of mTORC1Nature communicationsJanuary 10, 2020Charpentier JC, Chen D, Lapinski PE, Turner J, Grigorova I, Swanson JA, King PD.

(9) PAK Kinase Inhibition Has Therapeutic Activity in Novel Preclinical Models of Adult T-Cell Leukemia/LymphomaClinical cancer research : an official journal of the American Association for Cancer ResearchJune 15, 2019Chung EY, Mai Y, Shah UA, Wei Y, Ishida E, Kataoka K, Ren X, Pradhan K, Bartholdy B, Wei X, et al.

(12) Protein kinase D1 (PKD1) phosphorylation on Ser²⁰³ by type I p21-activated kinase (PAK) regulates PKD1 localizationThe Journal of biological chemistryJune 9, 2017Chang JK, Ni Y, Han L, Sinnett-Smith J, Jacamo R, Rey O, Young SH, Rozengurt E.

(13) RhoD Inhibits RhoC-ROCK-Dependent Cell Contraction via PAK6Developmental cellMay 8, 2017Durkin CH, Leite F, Cordeiro JV, Handa Y, Arakawa Y, Valderrama F, Way M.

(14) PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosisNature communicationsAugust 18, 2016Martin K, Pritchett J, Llewellyn J, Mullan AF, Athwal VS, Dobie R, Harvey E, Zeef L, Farrow S, Streuli C, et al.

(15) LeftyA decreases Actin Polymerization and Stiffness in Human Endometrial Cancer CellsScientific reportsJuly 11, 2016Salker MS, Schierbaum N, Alowayed N, Singh Y, Mack AF, Stournaras C, Schäffer TE, Lang F.

(17) 1α,25(OH)2D3 Induces Actin Depolymerization in Endometrial Carcinoma Cells by Targeting RAC1 and PAK1Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacologyJanuary 1, 2016Zeng N, Salker MS, Zhang S, Singh Y, Shi B, Stournaras C, Lang F.

(19) Mitotic cells contract actomyosin cortex and generate pressure to round against or escape epithelial confinementNature communicationsNovember 25, 2015Sorce B, Escobedo C, Toyoda Y, Stewart MP, Cattin CJ, Newton R, Banerjee I, Stettler A, Roska B, Eaton S, et al.

IPA 3