Poly(I:C) from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemPoly(I:C)
CompanyTocris Bioscience, a Bio-Techne Brand
Price $130.00Supplier Page View Company Product Page
Catalog Number4287/10
Quantity10 mg (also 50 mg)
Molecule NamePolyinosinic-polycytidylic acid sodium salt
Formula(C10H13N4O8P)x.(C9H14N3O8P)x
StorageStore at -20°C

Specifications/Features

Sizes Available: 10 mg (also 50 mg)

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Specific Assay Protocols for Porcine Single-Eye Retinal Pigment Epithelium Concerning Oxidative Stress and InflammationInternational Journal of Molecular SciencesAugust 29, 2025Philipp Dörschmann, Marie Prinz, Greta Schmitkall, Johann Roider, Alexa KlettnerO55:B5 (Merck, Darmstadt, Germany; #L4524), 10 µg/mL Poly I:C (PIC, Tocris Bioscience, Bristol, UK; #4287/10), or 50 ng/mL recombinant human tumor necrosis factor alpha (TNF, R&D systems, Minneapolis, MN, USA;

(2) Human eIF2A has a minimal role in translation initiation and in uORF-mediated translational control in HeLa cellsElifeJuly 2, 2025Mykola Roiuk, Marilena Neff, Aurelio A Telemanwith DMSO or with 100 µM Sodium arsenite (Sigma, S7400-100G), 1 µg/ml poly (I:C) (Tocris Bioscience, 4287/10), 1 µg/ml lipopolysaccharides LPC (Sigma, L2630), or 1 µg/ml tunicamycin (PanReac AppliChem, A2242,0005)

(3) Influence of a Very High-Molecular Weight Fucoidan from Laminaria hyperborea on Age-Related Macular Degeneration-Relevant Pathomechanisms in Ocular Cell ModelsMarine DrugsFebruary 25, 2025Philipp Dörschmann, Georg Kopplin, Tabea Thalenhorst, Charlotte Seeba, Sadia Fida Ullah, Vaibhav Srivastava, Johann Roider, Alexa Klettner28 (1 µg/mL LPS (Merck, Darmstadt, Germany; #L4524), 10 µg/mL PIC (Tocris Bioscience, Bristol, UK; #4287/10), 50 ng/mL TNF (R&D System, Minneapolis, MN, USA; 210-TA-005/CF), or 10 ng/mL Pam2CSK4 (Pam, Tocris Biosciences

(4) Disruption of immune responses by type 1 diabetes exacerbates SARS-CoV-2 mediated lung injuryAmerican Journal of Physiology-Lung Cellular and Molecular PhysiologyDecember 1, 2024Sara Kass-Gergi, Gan Zhao, Joanna Wong, Aaron I. Weiner, Stephanie Adams Tzivelekidis, Maria E. Gentile, Meryl Mendoza, Nicolas P. Holcomb, Xinyuan Li, Madeline Singh, et al.concentrations of polyinosinic:polycytidylic acid (poly I:C; 2 μg/mL and 10 μg/mL respectively; Bio-techne PN 4287/10) for 24 h before cells were harvested for RNA using the ProMega ReliaPrep RNA Miniprep System (PN Z6011).

(5) Regulation of HHLA2 expression in kidney cancer and myeloid cellsBMC cancerOctober 27, 2023Shigemura T, Perrot N, Huang Z, Bhatt RS, Sheshdeh AB, Ahmar NE, Ghandour F, Signoretti S, McDermott DF, Freeman GJ, et al.D3",100,ng/ml,,Supelco,H-107-1ML Pam3CSK4 (TLR1/2),5,μg/ml,,R&D Systems,4633/1 Poly(I:C) (TRL3),12.5,μg/ml,,R&D Systems,4287/10 Lipopolysaccharide (TLR4),5,μg/ml,,Invitrogen,00–4976-93 Imiquimod (TLR7),5,μg/ml,,R&D Systems,3700/50 Concentration

(6) Cultured fibroblasts of the Okinawa rail present delayed innate immune response compared to that of chickenPLoS OneAugust 22, 2023Masafumi Katayama, Tomokazu Fukuda, Noriko Kato, Takashi Nagamine, Yumiko Nakaya, Nobuyoshi Nakajima, Manabu Onumafibroblasts were exposed to 5 μg/mL or 50 μg/mL of poly I:C (polyinosinic-polycytidylic acid sodium salt) (4287/10; R&D Systems, Minneapolis, MN, USA). Poly I:C is a mixture of long and short reagents. During preculture

(7) Anti-inflammatory properties of antiangiogenic fucoidan in retinal pigment epithelium cellsHeliyonApril 1, 2023Dörschmann P, Seeba C, Thalenhorst T, Roider J, Klettner A.Germany; #L4524), 10 μg/mL polyinosinic:polycytidylic acid (Poly I:C, Tocris Bioscience, Bristol, UK; #4287/10), 50 ng/mL tumor necrosis factor alpha (TNF-α, R&D System, Minneapolis, USA; #210-TA/CF), or 10 ng/mL

(8) A p53-TLR3 axis ameliorates pulmonary hypertension by inducing BMPR2 via IRF3iScienceFebruary 17, 2023Bhagwani AR, Ali M, Piper B, Liu M, Hudson J, Kelly N, Bogamuwa S, Yang H, Londino JD, Bednash JS, et al.

(9) Genetic adaptation to pathogens and increased risk of inflammatory disorders in post-Neolithic EuropeCell GenomFebruary 8, 2023Kerner G, Neehus AL, Philippot Q, Bohlen J, Rinchai D, Kerrouche N, Puel A, Zhang SY, Boisson-Dupuis S, Abel L, et al.

(10) METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolismCell stem cellJanuary 5, 2023Han L, Dong L, Leung K, Zhao Z, Li Y, Gao L, Chen Z, Xue J, Qing Y, Li W, et al.ant-bl-05 G418 Sulfate,Thermo Fisher Scientific,Cat# 10131027; CAS: 108321-42-2 Poly(I:C),R&D systems,Cat# 4287/10 RetroNectin,Sigma-Aldrich,Cat# T202 L-Glutamine (200mM),Thermo Fisher Scientific,Cat# 25030-081 Ammonium Chloride Solution

(11) Identification of novel lactic acid bacteria with enhanced protective effects against influenza virusPloS oneJanuary 1, 2023Sugimoto A, Numaguchi T, Chihama R, Takenaka Y, Sato Y.well plates at a density of 4 × 105 cells/well for 24 h. Next, genomic DNA from LAB or Poly (I: C) (4287/10; R&D Systems, Minneapolis, MN, USA) was transfected into the cells at a final concentration of 5 and

(12) Organoids containing neural-like cells derived from chicken iPSCs respond to poly:IC through the RLR familyPloS oneJanuary 1, 2023Katayama M, Onuma M, Kato N, Nakajima N, Fukuda T.organoids were exposed to 5 μg/mL or 50 μg/mL poly I:C (polyinosinic-polycytidylic acid sodium salt) (4287/10; R&D Systems, Minneapolis, MN) for 6 h. We randomly chose nine-pieces from each dish (exposure of 0

(13) Assessing human iPSC-derived microglia identity and function by immunostaining, phagocytosis, calcium activity, and inflammation assaySTAR protocolsDecember 16, 2022Hübschmann V, Korkut-Demirbaş M, Siegert S.

(14) Poly I:C and R848 facilitate nitric oxide production via inducible nitric oxide synthase in chicksComparative biochemistry and physiology. Part A, Molecular & integrative physiologyJuly 1, 2022Tachibana T, Takahashi M, Khan S, Makino R, Cline MA.

(15) Epstein-Barr virus tegument protein BGLF2 in exosomes released from virus-producing cells facilitates de novo infectionCell communication and signaling : CCSJune 21, 2022Sato Y, Yaguchi M, Okuno Y, Ishimaru H, Sagou K, Ozaki S, Suzuki T, Inagaki T, Umeda M, Watanabe T, et al.GW4869 (Cat# 13127; Cayman Chemical, Ann Arbor, MI, USA). Transient transfection of poly(I:C) (Cat# 4287/10; R&D Systems, Minneapolis, MN, USA) was performed using Lipofectamine 2000 (Thermo Fisher Scientific)

(16) Pro-inflammatory activation changes intracellular transport of bevacizumab in the retinal pigment epithelium in vitroGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle OphthalmologieMarch 1, 2022Hildebrandt J, Käckenmeister T, Winkelmann K, Dörschmann P, Roider J, Klettner A.agonist polyinosinic:polycytidylic acid (Poly I:C; 1, 10, or 100 µg/ml; Tocris Bioscience, Bristol, UK; #4287/10). Time frame of experiments was 1 to 28 days. Medium was changed twice per week and Poly I:C and bevacizumab

(17) TRAF6 functions as a tumor suppressor in myeloid malignancies by directly targeting MYC oncogenic activityCell stem cellFebruary 3, 2022Muto T, Guillamot M, Yeung J, Fang J, Bennett J, Nadorp B, Lasry A, Redondo LZ, Choi K, Gong Y, et al.

(18) Stem cell-derived porcine macrophages as a new platform for studying host-pathogen interactionsBMC biologyJanuary 14, 2022Meek S, Watson T, Eory L, McFarlane G, Wynne FJ, McCleary S, Dunn LEM, Charlton EM, Craig C, Shih B, et al.

(19) Weight cycling induces innate immune memory in adipose tissue macrophagesFrontiers in immunologyJanuary 1, 2022Caslin HL, Cottam MA, Piñon JM, Boney LY, Hasty AH.

(20) Human Lung Fibroblasts Exhibit Induced Inflammation Memory via Increased IL6 Gene Expression and ReleaseFrontiers in immunologyJanuary 1, 2022Yap JMG, Ueda T, Kanemitsu Y, Takeda N, Fukumitsu K, Fukuda S, Uemura T, Tajiri T, Ohkubo H, Maeno K, et al.

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Poly(I:C)

Poly(I:C)

Poly(I:C) from Tocris Bioscience, a Bio-Techne Brand

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Specifications/Features

Tocris Bioscience, a Bio-Techne Brand

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Poly(I:C) from Tocris Bioscience, a Bio-Techne Brand

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